{"id":3108,"date":"2025-07-13T20:08:31","date_gmt":"2025-07-14T03:08:31","guid":{"rendered":"https:\/\/depts.washington.edu\/tlcart\/?p=3108"},"modified":"2025-07-13T20:11:11","modified_gmt":"2025-07-14T03:11:11","slug":"3108-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/tlcart\/3108-2\/","title":{"rendered":"New Clinical Report on Journal of Infectious Diseases"},"content":{"rendered":"<h1>New Clinical Report on Journal of Infectious Diseases<\/h1>\n<p>We wanted to share an exciting discovery that PK analysis of a long-acting 3-HIV drug injectable product called TLC-ART 101, containing a protease inhibitor Lopinavir (LPV) and a booster Ritonavir (RTV) (plus RT inhibitor Tenofovir) in humans suggests that booster ritonavir may not necessary.\u00a0 A single SC injection of LPV\/RTV in TLC-ART 101 provided about 2 months of plasma LPV levels while RTV was cleared within two days.\u00a0 Another surprising finding is that TLC-ART 101 lasted two weeks in primate model, but 2 months in humans. <a href=\"https:\/\/t.co\/TxACshibv0\">Follow this link for additional details, published at Journal of Infectious Diseases.\u00a0<\/a><\/p>\n<p>Implication: for long acting injectable protease inhibitor products, including those of HIV and Covid19 medicine be developed without boosters such as ritonavir or cobicistat.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3109\" src=\"https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/jiaf319f1-300x212.jpeg\" alt=\"\" width=\"350\" height=\"247\" srcset=\"https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/jiaf319f1-300x212.jpeg 300w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/jiaf319f1-1024x723.jpeg 1024w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/jiaf319f1-1536x1084.jpeg 1536w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/jiaf319f1-2048x1446.jpeg 2048w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/jiaf319f1-375x265.jpeg 375w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/jiaf319f1-1200x847.jpeg 1200w\" sizes=\"auto, (max-width: 350px) 100vw, 350px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New Clinical Report on Journal of Infectious Diseases We wanted to share an exciting discovery that PK analysis of a long-acting 3-HIV drug injectable product called TLC-ART 101, containing a protease inhibitor Lopinavir (LPV) and a booster Ritonavir (RTV) (plus RT inhibitor Tenofovir) in humans suggests that booster ritonavir may not necessary.\u00a0 A single SC injection of LPV\/RTV in TLC-ART 101 provided about 2 months of plasma LPV levels while RTV was cleared within two days.\u00a0 Another surprising finding is&#8230;<\/p>\n<div><a class=\"more-link\" href=\"https:\/\/depts.washington.edu\/tlcart\/3108-2\/\">Continue reading <span class=\"screen-reader-text\">New Clinical Report on Journal of Infectious Diseases<\/span><\/a><\/div>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-3108","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/posts\/3108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/comments?post=3108"}],"version-history":[{"count":6,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/posts\/3108\/revisions"}],"predecessor-version":[{"id":3115,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/posts\/3108\/revisions\/3115"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/media?parent=3108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/categories?post=3108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/tags?post=3108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}