In choosing the Breakthrough of the Year in 2013, the editors of Science recognized years of efforts toward the tantalizing goal of enlisting the body’s own immune system to fight cancer . Since then, we have seen the acceleration of multiple approaches from the laboratory to the clinic including immune checkpoint blockade, adoptive cellular therapy, and cancer vaccines. How these strategies fare in clinical trials may ultimately lead to paradigm shifts in therapy. This article will outline rationales for immunotherapy in gynecologic cancers and highlight but a few of the many recent developments in applying these technologies.
Immunotherapy for gynecologic cancers
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