This project is designed to provide preclinical assessment of the concept that kappa opioid receptor (KOR) antagonists have therapeutic potential in the adjunctive treatment of depressive disorders. The underlying hypotheses of this project are that repeated stress exposure causes dynorphin release that can exacerbate depressive symptoms; that individuals at risk of depression have lowered stress-resilience … Continue reading Project 1: Therapeutic Potential of Kappa Opioid Receptor Antagonists in the Treatment of Depression (Chavkin)