UW Medicine

Jason Bielas

Jason Bielas

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Associate Member, Translational Research Program, Fred Hutchinson Cancer Research Center
Affiliate Association Professor, Lab Medicine and Pathology

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Role of DNA mutation in aging and cancer Dr. Bielas is an Associate Member in the Translational Research Program at the Fred Hutchinson Cancer Research Center, and an Affiliate Associate Professor in the UW Department of Lab Medicine and Pathology. He has a long-standing interest in the relationships between aging, mutagenesis, and cancer. His past […]

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Alessandro Bitto

Alessandro Bitto

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Acting Instructor of Lab Medicine and Pathology

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Dr. Bitto is an Acting Instructor in the Department of Lab Medicine and Pathology. His research is focused on understanding the interaction between biological aging, mitochondrial function, and metabolic disease. Dr. Bitto was a BMHA post-doctoral fellow on the Genetic Approaches to Aging Training Grant from 2013-2016 and is the recipient of a post-doctoral research […]

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Ian Dowsett

Ian Dowsett

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Mr. Dowsett is a graduate student in the M3D Ph.D. program performing his thesis research in the laboratory of Dr. Alan Herr. He is a pre-doctoral trainee in the BHMA Training Program. Dr. Herr serves as his primary mentor and Dr. Kaeberlein serves as his senior mentor. Mr. Dowsett’s research is focused on understanding the […]

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Alan Herr

Alan Herr

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Research Associate Professor, Department of Lab Medicine and Pathology

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Dr. Herr studies the influence of genetic instability on the aging process, as well as basic mechanisms of mutator phenotypes resulting from error prone replication.  He has NIA R01 funding to support the use of budding yeast to measure the error rates of mutator cells at each division of their replicative lifespan.  Despite decades of […]

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Matt Kaeberlein

Matt Kaeberlein

Titles

Director, Healthy Aging and Longevity Research Institute
Director, Biological Mechanisms of Healthy Aging Training Program
Co-Director, UW Nathan Shock Center of Excellence in the Basic Biology of Aging
Co-Director, Dog Aging Project
Professor of Pathology
Adjunct Professor of Genome Sciences
Adjunct Professor of Oral Health Sciences

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Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the […]

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C. Dirk Keene

C. Dirk Keene

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Associate Professor of Lab Medicine and Pathology

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Dr. Keene received his education at the University of Nevada, Las Vegas (B.S. in Cell and Molecular Biology) and the University of Minnesota (M.D. and Ph.D. in Neuroscience). His post-graduate medical training in Anatomic Pathology and Neuropathology was at the University of Washington where he earned a faculty position in Neuropathology. Currently, Dr. Keene is […]

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Scott Kennedy

Scott Kennedy

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Assistant Professor of Lab Medicine and Pathology

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Mitochondrial mutagenesis in aging and neurodegeneration Dr. Kennedy is an Assistant Professor in the Department of Lab Medicine and Pathology. Dr. Kennedy has a long standing interest in elucidating how somatic mutations, primarily focused on the mitochondrial genome, influence aging and age associated diseases, such as neurodegeneration. During his post-doctoral training with Dr. Lawrence A. […]

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Michael MacCoss

Michael MacCoss

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Professor of Genome Sciences

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Applications of mass spectrometry in the biology of aging The focus of Dr. MacCoss’ laboratory is in the development and application of cutting edge mass spectrometry based technologies for the analysis of complex protein mixtures. His primary area of expertise is in protein biochemistry, nanoflow liquid chromatography, mass spectrometry instrumentation, and computational analysis of mass […]

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David Marcinek

David Marcinek

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Professor of Radiology
Adjunct Professor of Bioengineering
Adjunct Professor of Lab Medicine and Pathology

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Dr. Marcinek joined the UW faculty in 2006. He has over 15 years of experience developing and applying innovative tools to study mitochondrial biology in chronic disease and aging. A main focus of his laboratory is to understand how age-related changes in mitochondrial function at the biochemical and organelle levels translate to changes in in […]

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George Martin

George Martin

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Emeritus Professor of Lab Medicine and Pathology
Emeritus Professor of Genome Sciences

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Dr. Martin has led a long and productive career at the University of Washington, where he received his BS and MD degrees and has been a member of its faculty since 1957. He worked as a surgical pathologist and cytogeneticist in the UW Department of Pathology since 1957, and he served as the founding director […]

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Alexander Mendenhall

Alexander Mendenhall

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Assistant Professor of Lab Medicine and Pathology

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Dr. Mendenhall’s laboratory utilizes the nematode C. elegans to understand how and why genetically identical populations of cells and animals in the same environment age differently. How much and what kind of physiological variation is intrinsic/chance based, or is programmed and heritable? The lab takes the approach of directly observing events inside of living cells […]

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Daniel Promislow

Daniel Promislow

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Professor of Lab Medicine and Pathology
Professor of Biology

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Dr. Promislow studies natural genetic variation in aging and reproduction. His research is focused on aging in several systems – the fruit fly, companion dogs, and humans. He uses a diversity of approaches in his lab, including molecular and quantitative genetics, evolutionary theory, and systems biology to construct and analyze genetic and metabolomic networks. Among […]

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Peter Rabinovitch

Peter Rabinovitch

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Professor, Department of Lab Medicine and Pathology
Joint Full Member, Fred Hutchinson Cancer Research Center

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Mitochondrial function and healthspan Peter Rabinovitch has served on the faculty of the Department of Lab Medicine and Pathology since 1983. He has been an active investigator in the biology of aging throughout his career, is the author of over 290 peer-reviewed publications, and is the founding director of the UW Nathan Shock Center of […]

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Shane Rea

Shane Rea

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Associate Professor of Lab Medicine and Pathology

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C. elegans aging and healthspan extension Dr. Rea is an Associate Professor of Lab Medicine and Pathology. His laboratory utilizes the nematode Caenorhabditis elegans to probe the fundamental mechanisms of aging and mitochondrial dysfunction in humans. His research spanning three decades has revealed that nematode lifespan is controlled by a roughly equal mix of genetics, […]

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Rosana Risques

Rosana Risques

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Associate Professor of Lab Medicine and Pathology

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Genomic instability, cancer and aging The main focus of Dr. Risques’ research is the study of the molecular mechanisms that link genomic instability and aging. The main molecular alterations that her lab studies are telomere shortening, mitochondrial dysfunction, and age-related accumulation of somatic mutations.  She has published on comparative analyses of aging relating telomere length […]

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Rong Tian

Rong Tian

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Professor of Bioengineering
Professor of Anesthesiology
Adjunct Professor of Biochemistry
Director, Mitochondria and Metabolism Center

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Cardiac metabolism and mitochondrial energetics The Tian Lab studies cell metabolism and mitochondrial function in living systems. Our goal is to improve cellular resistance to environmental stresses and diseases through engineering metabolism. […]

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Paul Valdmanis

Paul Valdmanis

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Assistant Professor, Medical Genetics
Adjunct Assistant Professor, Genome Sciences
Adjunct Assistant Professor, Lab Medicine and Pathology

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Age-associated changes in synaptic non-coding RNAs Dr. Valdmanis joined the UW as an Assistant Professor in 2017.  His research has historically been focused on identification of mutations in genes that are responsible for neurodegenerative diseases such as ALS.  Recently, he has begun studying the role of non-coding RNAs in synaptic aging.  He has hypothesized that […]

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Jessica Young

Jessica Young

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Assistant Professor of Lab Medicine and Pathology

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Dr. Young joined the UW faculty in 2016 as an Assistant Professor in the Department of Lab Medicine and Pathology.  Her research goal is to understand the molecular and biochemical mechanisms underlying age-related disorders, with a particular focus on neurodegenerative disorders.  She has developed human stem cell models to further this line of research, as […]

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