UW Medicine

David Baker

David Baker

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Professor of Biochemistry
Adjunct Professor of Genome Sciences
Director, Institute for Protein Design

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Innovation in protein design to target aging and age-related disease Dr. Baker has pioneered methods to predict and design the three-dimensional structures of proteins. He is the Henrietta and Aubrey Davis Endowed Professor in Biochemistry and an adjunct professor of Genome Sciences, Bioengineering, Chemical Engineering, Computer Science, and Physics. He serves as the Director of […]

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William Banks

William Banks

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Professor, Division of Gerontology & Geriatric Medicine
Adjunct Professor, Department of Psychiatry & Behavioral Science

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Decline in blood-brain barrier function during aging Dr. Banks is Professor, Division of Gerontology & Geriatric Medicine and Associate Director for Research of the Puget Sound Geriatric Research Education and Clinical Center. The major focus of his research is the study of how the brain and body communicate with one another through the transfer of […]

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Antonio Bedalov

Antonio Bedalov

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Associate Member, Clinical Research Division, Fred Hutchinson Cancer Research Center

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Genome replication and its role in aging Dr. Bedalov is an Associate Member in the Clinical Research Division at the Fred Hutchinson Cancer Research Center.  Dr. Bedalov is a bone marrow transplant specialist who treats people for blood disorders, leukemia, lymphoma, multiple myeloma and myelodysplastic syndrome.  He runs an active research laboratory that uses S. […]

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Jason Bielas

Jason Bielas

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Associate Member, Translational Research Program, Fred Hutchinson Cancer Research Center
Affiliate Association Professor, Lab Medicine and Pathology

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Role of DNA mutation in aging and cancer Dr. Bielas is an Associate Member in the Translational Research Program at the Fred Hutchinson Cancer Research Center, and an Affiliate Associate Professor in the UW Department of Lab Medicine and Pathology. He has a long-standing interest in the relationships between aging, mutagenesis, and cancer. His past […]

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Darrian Bugg

Darrian Bugg

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Ms. Bugg is an M3D graduate student in Pathology performing her Ph.D. thesis studies in the Davis Lab focusing on how various cardiac fibroblast cell state changes affect cardiac physiology over time. In particular she is focusing on understanding how fluid these changes are and if there is the possibility to revert to a healthy […]

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Marie Davis

Marie Davis

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Assistant Professor of Neurology

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Dr. Davis is a movement disorder neurologist and researcher at the VA Puget Sound Healthcare System and and Assistant Professor in the Department of Neurology at the University of Washington. Her research focuses on understanding the mechanisms underlying the production and spread of pathogenic protein aggregation in aging and aging-related neurodegenerative diseases, in particular Parkinson’s […]

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Ian Dowsett

Ian Dowsett

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Mr. Dowsett is a graduate student in the M3D Ph.D. program performing his thesis research in the laboratory of Dr. Alan Herr. He is a pre-doctoral trainee in the BHMA Training Program. Dr. Herr serves as his primary mentor and Dr. Kaeberlein serves as his senior mentor. Mr. Dowsett’s research is focused on understanding the […]

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Maitreya Dunham

Maitreya Dunham

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Professor of Genome Sciences

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Aneuploidy, evolution, and aging. Dr. Dunham develops and applies genomic tools to study genome evolution and genetic variation in yeast and humans. She has a special interest in how gene and chromosome copy number variation contributes to adaptation, the mechanisms by which such variation arises, and the relationship between aneuploidy and aging.  They utilize the budding […]

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Dan Eisenberg

Dan Eisenberg

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Associate Professor of Anthropology
Adjunct Associate Professor of Biology

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Dr. Eisenberg is a biological anthropologist who studies how evolution has shaped human biology and aging. Dan’s research is primarily on telomere biology and has principally been in collaboration with population-based studies in non-western contexts such as the Cebu Longitudinal Health and Nutrition Survey in the Philippines and the Tsimane’ Amazonian Panel Study in Bolivia. […]

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Richard Gardner

Richard Gardner

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Professor of Pharmacology

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Proteostasis and aging The accumulation of structurally aberrant proteins underlies over 30 human disorders.  These include such devastating diseases as Alzheimer’s, Parkinson’s, Huntington’s, and ALS. Collectively, these disorders are called “protein aggregation” disorders because protein inclusions are usually observed in affected cells. Some protein aggregation diseases result from toxic accumulation in the cytoplasm and extracellular […]

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Kelley Harris

Kelley Harris

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Assistant Professor of Genome Sciences

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Dr. Harris uses population genetic theory and high-throughput biological sequence analysis to study recent evolutionary history in humans and other species. One are of particular interest is the evolution of mutagenesis the forces that control DNA replication fidelity, the mutational breakdown of established traits, and the ultimate origin of new traits. Although DNA is replicated and […]

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Alan Herr

Alan Herr

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Research Associate Professor, Department of Lab Medicine and Pathology

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Dr. Herr studies the influence of genetic instability on the aging process, as well as basic mechanisms of mutator phenotypes resulting from error prone replication.  He has NIA R01 funding to support the use of budding yeast to measure the error rates of mutator cells at each division of their replicative lifespan.  Despite decades of […]

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James Hurley

James Hurley

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Professor of Biochemistry

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The Hurley lab focuses on understanding how energy metabolism is controlled in photoreceptors and how this changes with age. In darkness, photoreceptors consume energy rapidly to offset the leakage of ions across the plasma membrane. Light stops that leakage but it introduces qualitatively different energy demands. Dr. Hurley and his colleagues are investigating how the […]

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Matt Kaeberlein

Matt Kaeberlein

Titles

Director, Healthy Aging and Longevity Research Institute
Director, Biological Mechanisms of Healthy Aging Training Program
Co-Director, UW Nathan Shock Center of Excellence in the Basic Biology of Aging
Co-Director, Dog Aging Project
Professor of Pathology
Adjunct Professor of Genome Sciences
Adjunct Professor of Oral Health Sciences

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Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the […]

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Scott Kennedy

Scott Kennedy

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Assistant Professor of Lab Medicine and Pathology

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Mitochondrial mutagenesis in aging and neurodegeneration Dr. Kennedy is an Assistant Professor in the Department of Lab Medicine and Pathology. Dr. Kennedy has a long standing interest in elucidating how somatic mutations, primarily focused on the mitochondrial genome, influence aging and age associated diseases, such as neurodegeneration. During his post-doctoral training with Dr. Lawrence A. […]

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Mary-Claire King

Mary-Claire King

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Professor of Genome Sciences
Professor of Medical Genetics

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Aging factors in complex heritable conditions. Dr. King’s group uses next generation sequencing approaches to identify genes responsible for complex human conditions. Since the 1970s, her group has exploited approaches from genetics, then molecular biology, then genomics to discover and characterize genes for inherited disease. There are four areas of her work that offer insights […]

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Rachel Klevit

Rachel Klevit

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Edmond H. Fischer/WRF Endowed Chair in Biochemistry
Adjunct Professor of Chemistry
Adjunct Professor of Pharmacology

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Understanding of molecular recognition, and interactions that play important roles in aging and disease  Dr. Klevit is the Edmond H. Fischer/WRF Endowed Chair in Biochemistry, an Adjunct Professor of Pharmacology, and Adjunct Professor of Chemistry. Current research in Dr. Klevit’s laboratory is directed towards an understanding of fundamental molecular recognition events involved in the process […]

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Warren Ladiges

Warren Ladiges

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Professor of Comparative Medicine

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Geropathology and mouse models in translational geroscience Dr. Ladiges is Professor of comparative medicine and Director of the Geropathology Research Network and the UW Nathan Shock Center Geropathology Resource. He has extensive experience in the pathobiological evaluation and modeling of mice for preclinical aging and intervention studies and has been a leader in the application […]

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Su-In Lee

Su-In Lee

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Associate Professor, Paul G. Allen School of Computer Science & Engineering
Associate Professor, Genome Sciences

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Understanding aging through explainable machine learning The Lee lab seeks to develop explainable AI for life sciences.  Explainable in this context means understanding which features drive the prediction.  The Lee lab has been collaborating with the Kaeberlein lab to develop and apply machine learning to aging biology, with the initial goal of using noisy human […]

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Michael MacCoss

Michael MacCoss

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Professor of Genome Sciences

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Applications of mass spectrometry in the biology of aging The focus of Dr. MacCoss’ laboratory is in the development and application of cutting edge mass spectrometry based technologies for the analysis of complex protein mixtures. His primary area of expertise is in protein biochemistry, nanoflow liquid chromatography, mass spectrometry instrumentation, and computational analysis of mass […]

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David Marcinek

David Marcinek

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Professor of Radiology
Adjunct Professor of Bioengineering
Adjunct Professor of Lab Medicine and Pathology

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Dr. Marcinek joined the UW faculty in 2006. He has over 15 years of experience developing and applying innovative tools to study mitochondrial biology in chronic disease and aging. A main focus of his laboratory is to understand how age-related changes in mitochondrial function at the biochemical and organelle levels translate to changes in in […]

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George Martin

George Martin

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Emeritus Professor of Lab Medicine and Pathology
Emeritus Professor of Genome Sciences

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Dr. Martin has led a long and productive career at the University of Washington, where he received his BS and MD degrees and has been a member of its faculty since 1957. He worked as a surgical pathologist and cytogeneticist in the UW Department of Pathology since 1957, and he served as the founding director […]

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Alexander Mendenhall

Alexander Mendenhall

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Assistant Professor of Lab Medicine and Pathology

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Dr. Mendenhall’s laboratory utilizes the nematode C. elegans to understand how and why genetically identical populations of cells and animals in the same environment age differently. How much and what kind of physiological variation is intrinsic/chance based, or is programmed and heritable? The lab takes the approach of directly observing events inside of living cells […]

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Dana Miller

Dana Miller

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Associate Professor of Biochemistry

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Dr. Miller’s lab uses C. elegans to define relationships between proteostasis, the responses to hypoxia and hydrogen sulfide, and fasting. This work is also at the crux of understanding the relationships between stress response and aging. She has found that protein homeostasis is disrupted by exposure to specific hypoxic O2 concentrations [66]. One goal of […]

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Claudia Moreno

Claudia Moreno

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Assistant Professor of Physiology and Biophysics

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Molecular Basis of Aging The goal of the Moreno lab is to understand how the function and regulation of ion channels change during the natural process of aging. Aging comes with a vast set of impairments, hearing loss, cardiac dysfunction, and hypertension, are only a few on the list. Most of these impairments are caused […]

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Phillip G. Morgan

Phillip G. Morgan

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Professor, Department of Anesthesiology and Pain Medicine
Principal Investigator, Seattle Children's Research Institute

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Research Interest Research in the Morgan lab is focused on the role of mitochondrial function in disease, anesthetic response and aging.  We primarily utilize mutants in C. elegans and mice to uncover genetic factors that modulate mitochondrial biochemistry.  Selected publications Suthammarak W, Morgan PG, Sedensky MM. (2010). Mutations in mitochondrial complex III uniquely affect complex I in Caenorhabditis […]

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Leo Pallanck

Leo Pallanck

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Professor of Genome Sciences

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Mitochondrial quality control in aging. Much of Dr. Pallanck’s current work stems from his studies of Drosophila homologs of the Parkinson’s disease-related genes parkin and PINK1. His work on Parkin and PINK1 led to his hypothesis that these factors promote the degradation of damaged mitochondria through mitophagy, a mitochondrial-selective form of autophagy. Work in many […]

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Daniel Promislow

Daniel Promislow

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Professor of Lab Medicine and Pathology
Professor of Biology

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Dr. Promislow studies natural genetic variation in aging and reproduction. His research is focused on aging in several systems – the fruit fly, companion dogs, and humans. He uses a diversity of approaches in his lab, including molecular and quantitative genetics, evolutionary theory, and systems biology to construct and analyze genetic and metabolomic networks. Among […]

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Christine Queitsch

Christine Queitsch

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Professor of Genome Sciences

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Gene regulation and heritable phenotypic variation in aging The Queitsch lab focuses on two related fields: the genetic architecture of complex traits and the role of gene regulation and protein folding in generating heritable phenotypic variation – including phenotypes of aging. We advance complex trait genetics by ascertaining uncharacterized sequence variation and by resolving the […]

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Peter Rabinovitch

Peter Rabinovitch

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Professor, Department of Lab Medicine and Pathology
Joint Full Member, Fred Hutchinson Cancer Research Center

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Mitochondrial function and healthspan Peter Rabinovitch has served on the faculty of the Department of Lab Medicine and Pathology since 1983. He has been an active investigator in the biology of aging throughout his career, is the author of over 290 peer-reviewed publications, and is the founding director of the UW Nathan Shock Center of […]

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Stephan Raiders

Stephan Raiders

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Mr. Raiders is a PhD candidate in the Molecular and Cellular Biology Ph.D. program. He performs his research in the lab of Dr. Aakanksha Singhvi, studying molecular interactions between neurons and their supporting cells, glia, using the small nematode worm, C. elegans. Mr. Raiders studies the pruning of sensory neurons by associated glial cells and […]

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Shane Rea

Shane Rea

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Associate Professor of Lab Medicine and Pathology

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C. elegans aging and healthspan extension Dr. Rea is an Associate Professor of Lab Medicine and Pathology. His laboratory utilizes the nematode Caenorhabditis elegans to probe the fundamental mechanisms of aging and mitochondrial dysfunction in humans. His research spanning three decades has revealed that nematode lifespan is controlled by a roughly equal mix of genetics, […]

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May J. Reed

May J. Reed

Titles

Associate Professor of Gerontology and Geriatric Medicine
Section Chief, Harborview Medical Center
Medical Director, Senior Care Clinic

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Dr. Reed is Section Chief of Geriatric Medicine at Harborview, Medical Director of the HMC Senior Care Clinic and UW Associate Professor in the Department of Medicine, Division of Gerontology and Geriatric Medicine.  She is also Associate Director of the Geriatric Medicine Fellowship Program. Dr. Reed’s longstanding interest is in evaluating the effects of the […]

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Mike Regnier

Mike Regnier

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Professor of Bioengineering

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Mechanisms of tissue dysfunction during aging Dr. Regnier is a Professor and Interim Chair of Bioengineering at UW.  Dr. Regnier’s research goal is to develop novel approaches to prevent or restore age-related loss of muscle function, such as protein, cell & tissue engineering and gene therapy.  Research in the Regnier lab is interdisciplinary and studies […]

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Rosana Risques

Rosana Risques

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Associate Professor of Lab Medicine and Pathology

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Genomic instability, cancer and aging The main focus of Dr. Risques’ research is the study of the molecular mechanisms that link genomic instability and aging. The main molecular alterations that her lab studies are telomere shortening, mitochondrial dysfunction, and age-related accumulation of somatic mutations.  She has published on comparative analyses of aging relating telomere length […]

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Hannele Ruohola-Baker

Hannele Ruohola-Baker

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Professor of Biochemistry
Adjunct Professor of Biology
Adjunct Professor of Genome Sciences

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Adult stem cell aging Dr. Ruohola-Baker’s laboratory studies the molecules and cellular properties that are required for stem cell states and their differentiation capacity. During the recent years the laboratory has shown that microRNAs and the HIF pathway play key roles in regulating adult and embryonic stem cell self-renewal in model organisms as well as […]

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Margaret M. Sedensky

Margaret M. Sedensky

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Principal Investigator, Seattle Children’s Research Institute
Professor, Anesthesiology and Pain Medicine

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Research Interest The Sedensky laboratory is using two model systems to understand multiple ramifications of mitochondrial dysfunction. Lifespan and neurodegeneration are two areas under active investigation. A long standing focus is understanding how mitochondrial function controls behavior in the volatile anesthetics. Selected publications Falk MJ, Kayser EB, Morgan PG, Sedensky MM. (2006). Mitochondrial complex I function […]

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Aakanksha Singhvi

Aakanksha Singhvi

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Assistant Professor, Fred Hutchinson Cancer Research Center
Affiliate Assistant Professor, Dept. Biological Structure, UW School of Medicine

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Dr. Singhvi’s lab investigates the role of glia in neural function, aging and disease. Our nervous system has two major cell types, glia and neurons, in about equal numbers. Glia communicate with neurons to modulate neuron shape and function, and thereby neural circuit activity and animal behaviors. To define the molecular basis of neural aging, […]

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Paul Valdmanis

Paul Valdmanis

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Assistant Professor, Medical Genetics
Adjunct Assistant Professor, Genome Sciences
Adjunct Assistant Professor, Lab Medicine and Pathology

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Age-associated changes in synaptic non-coding RNAs Dr. Valdmanis joined the UW as an Assistant Professor in 2017.  His research has historically been focused on identification of mutations in genes that are responsible for neurodegenerative diseases such as ALS.  Recently, he has begun studying the role of non-coding RNAs in synaptic aging.  He has hypothesized that […]

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Judit Villen

Judit Villen

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Associate Professor of Genome Sciences

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Dr. Villen is an Associate Professor in the Department of Genome Sciences. She earned her PhD in Chemistry from the University of Barcelona. During her postdoc at Harvard Medical School she was involved in several technology developments that enabled the robust characterization of thousands of phosphorylation sites: from biochemical methods to mass spectrometry acquisition strategies […]

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Andrea Wills

Andrea Wills

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Assistant Professor of Biochemistry

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Dr. Wills joined the UW Biochemistry faculty as an Assistant Professor in 2015.  Her research is focused on understanding the genetic and epigenetic mechanisms of regeneration using the diploid frog Xenopus tropicalis as a model organism.  Loss of regenerative capacity is a fundamental aspect of aging biology.  The Wills lab uses high-throughput sequencing approaches (RNA-Seq, ChIP-Seq, ATAC-Seq) […]

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Jessica Young

Jessica Young

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Assistant Professor of Lab Medicine and Pathology

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Dr. Young joined the UW faculty in 2016 as an Assistant Professor in the Department of Lab Medicine and Pathology.  Her research goal is to understand the molecular and biochemical mechanisms underlying age-related disorders, with a particular focus on neurodegenerative disorders.  She has developed human stem cell models to further this line of research, as […]

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