Occludin
Transporter Elucidation Center (TEC) Overall Goal
The broad goals of this Transporter Elucidation Center (TEC) at the University of Washington are:
- to identify and quantify transporters in the human placenta from early gestation to term, and in the developing gut (fetal and neonate/infant);
- to functionally characterize and determine the cellular localization of the highly abundant transporters identified in these human organs.
Collectively, these studies will provide clinically and mechanistically important data for understanding transporters that control absorption and distribution of nutrients (including vitamins) and xenobiotics (FDA approved drugs and dietary supplements) in the developing fetus and neonate/infant.