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Vol. IV, No. 09 ~ EINet News Briefs ~ May 31, 2001


****A free service of the APEC Emerging Infections Network*****

The EINet listserv was created to foster discussion, networking, and collaboration in the area of emerging infectious diseases (EID's) among academicians, scientists, and policy makers in the Asia–Pacific region. We strongly encourage you to share their perspectives and experiences, as your participation directly contributes to the richness of the "electronic discussions" that occur. To respond to the listserv, use the reply function.


In this edition:

  1. Infectious disease information
  2. Updates
  3. Notices
  4. How to join the EINet listserv


1. OVERVIEW OF INFECTIOUS–DISEASE INFORMATION  
Below is a bi–monthly summary of Asia–Pacific emerging infectious diseases.

ASIA

CHINA (HONG KONG) – INFLUENZA A (H5N1) VIRUS IN POULTRY
Following the detection of avian influenza A (H5N1) virus in chickens at ten poultry markets in Hong Kong, health officials ordered the slaughter of approximately two million chickens at markets and farms throughout the territory. Hong Kong has also requested that mainland China halt exports of live birds to the territory. No human cases have been detected, but the influenza was highly virulent among chickens, killing almost all of the infected chickens within days. The virus strains isolated from the chickens differ genetically from the H5N1 virus that spread to humans and killed six people in 1997. Since that outbreak, Hong Kong has conducted routine testing for the H5N1 virus in poultry at retail markets. In April, officials detected an H5N1 virus similar to the current strain, but it did not cause death in chickens, as the current strain does. The ten infected markets have been shut down and, following the destruction of the chickens, will be thoroughly disinfected. According to Lily Yam, the Secretary for the Environment and Food in Hong Kong, the vast majority of H5N1 strains do not affect humans; however, there is always the possibility that the strains may combine with other viruses to produce a strain that could infect humans.
[WHO 5/17/01, 5/18/01, http://www.who.int/disease–outbreak–news/n2001/may/17may2001.html; THE NEW YORK TIMES 5/16/01, http://www.nytimes.com]

MALAYSIA (KUALA LUMPUR)– CHOLERA OUTBREAK
Health authorities stated that the outbreak of cholera near Kuala Lumpur that killed one person and is believed to have affected 146 others has been contained and is under control. Officials ordered the closure of 132 food stalls, restaurants, and factory canteens in the western Malaysian state of Selangor. The source of the outbreak has not yet been identified.
[ASSOCIATED PRESS 5/13/01, 5/15/01]

SOUTH KOREA – E. COLI 026 INFECTION
A man was diagnosed with E. coli 026 bacterial infection after being hospitalized as a result of food poisoning. This strain is similar to E. coli 0157, which was first found in the U.S. in 1982. This case represents the second E. coli 026 patient diagnosed in Korea since 1999, when the infection was designated a communicable disease. Additional information on this, such as the source of the infection, would be helpful and can be sent to apecein@u.washington.edu.
[PROMED 5/9/01]


AMERICAS

CANADA (ONTARIO) – POSSIBLE SURGICAL CJD TRANSMISSION
A woman who was operated on at the Hotel–Dieu Grace Hospital in Windsor on March 11, 2001, later tested positive for Creutzfeldt–Jakob Disease (CJD). Neurosurgeons at the hospital learned of the test result, which is about 85 percent accurate, on May 7. The hospital subsequently suspended all surgery and disinfected the operating rooms and surgical equipment. The hospital has begun contacting patients who have undergone neurosurgery since March. While the risk of iatrogenic transmission is very small, normal sterilization protocols reduce, but do not eliminate that risk, as the infectious agent is resistant to standard sterilization procedures. Iatrogenic transmission of CJD from contaminated surgical instruments such as dura mater grafts has been reported previously in Japan and Thailand. As of November 1997, approximately 43 patients were believed to have contracted the infection in this manner in Japan. CJD is extremely rare and leads to progressive dementia and loss of physical functions, inevitably resulting in death.
[PROMED 5/14/01, 11/20/97]

CANADA (SASKATCHEWAN) – CRYPTOSPORIDIOSIS OUTBREAK
More than 100 flu–like illnesses in the town of North Battleford in west–central Saskatchewan are believed to be the result of a contaminated water supply. The parasite, Cryptosporidium parvum, was found in a water–treatment plant that serves the town, and is presumed to have entered the water supply through a faulty filtration system. Health officials stated that 36 cases of cryptosporidiosis have been confirmed through laboratory testing, and may have been responsible for one death. The Environment Department recently released the names of 119 communities in Saskatchewan that have problems with their water treatment facilities. According to the Environment Minister, nearly a third of these lack minimum treatment standards.
[REUTERS 5/7/01; PROMED 5/6/01, CANADIAN PRESS 5/16/01]

CANADA (OTTAWA) – METHICILLIN–RESISTANT STAPHYLOCOCCUS AUREUS OUTBREAK IN HOSPITALS
Ottawa hospitals have treated about 50 cases of methicillin–resistant Staphylococcus aureus (MRSA) following its introduction into a hospital by a patient from the United Kingdom. The director of the Ottawa Hospital’s Infection Prevention and Control Program emphasized that the community is not at risk and that this particular bacteria is not particularly dangerous as it can be successfully treated with antibiotics. The hospitals have had to respond to MRSA outbreaks since 1990. Nonetheless, hospital officials state that they are following strict procedures such as isolating infected patients. In a hospital outbreak, patients with weak immune systems are those most susceptible to the infection.
[OTTAWA CITIZEN 5/17/01, http://www.ottawacitizen.com]

CANADA (ALBERTA) – CALICIVIRUS OUTBREAK IN SCHOOL
An outbreak of viral gastroenteritis affected 163 children and 16 teachers at an elementary school in Calgary on May 2. The virus has been identified as belonging to the calicivirus family, and samples have been sent to the Centers for Disease Control and Prevention (CDC) for further testing. Caliciviruses are commonly spread through the consumption of contaminated food or beverages, and can cause nausea, diarrhea, vomiting, abdominal pain, fever, and malaise. While the source of the infection is not clear, the school’s water has been ruled out as a possible source. The school has disinfected the walls, floors, and handrails in order to minimize the risk of further infections.
[CANADIAN PRESS 5/16/01; PROMED 5/17/01]

U.S. (NJ) – WEST NILE VIRUS DETECTED IN CROWS
As of May 20, five crows found dead in two counties of New Jersey have tested positive for the West Nile Virus (WNV). Both of these counties exhibited high crow mortality last year. Most counties in New Jersey have been conducting surveillance activities since March, but these are the first reports of WNV in the country in 2001. Testing dead birds has proven to be an effective early–warning system, as the virus can infect birds before it infects people. Such increased awareness can alert health officials to the need to increase surveillance and control measures of mosquito populations.

WNV first appeared in New York two years ago. Since then, it has infected tens of thousands of birds and at least 81 people, including nine deaths. The most effective way to prevent infection is to take precautions to reduce the risk of being bitten by a mosquito.
[NJ WNV WEB SITE, http://www.state.nj.us/governor/westnile/index.html; PROMED
5/7/01, 5/8/01, 5/15/01, 5/20/01]


MEXICO – SUSPECTED IMPORTED MEASLES

A small outbreak of measles in the Benito Juarez Municipality in Mexico occurred in a 33–year–old male of U.S. nationality and his wife and daughter. The index case was the 33–year–old male, whose illness began on April 13. He had recently had contact with some Koreans on March 15, and had traveled to a convention in Dallas on March 22. According to the Texas Department of Health, there has been only one reported case of measles in the state, which occurred in an adoptee exposed in China with onset on February 14. The CDC confirmed that there were no reported cases that may have traveled through Dallas or Houston during the relevant time period in March. While there has been an outbreak in Korea with approximately 40,000 cases, the date of contact with the Koreans is outside of the average 14–day exposure period. It is not known whether any specimens for viral isolation were obtained from the index case.
[PROMED 5/4/01, 5/5/01]

EL SALVADOR – SUSPECTED IMPORTED MEASLES
The El Salvador Ministry of Health confirmed the first two cases of measles in the country since eradication of the disease in 1996. The cases occurred in two brothers who recently returned from Europe. The cases are thought to be imported. In response, health authorities announced plans to vaccinate university students, and to establish sanitary cordons in the international airport and at overland border crossings. Neighboring countries have also enhanced prevention measures by increasing vaccinations and notifying residents of border regions. The Guatemalan government sent 200,000 doses of measles vaccine to the El Salvadoran Ministry of Health.
[PROMED 5/14/01, 5/17/01]


OTHER

RUSSIA (KALUGA and UDMURTSKAYA) – SHIGELLOSIS OUTBREAK
Two outbreaks of acute dysentery occurred in late April and early May in the Kaluga province and the Udmurtskaya Republic in Russia. In Kaluga, 158 cases of acute dysentery were reported at a psychiatric hospital between April 29 and May 3. Isolation of the bacteria from 66 cases identified the Shigella flexneri 2a strain to be the cause of the infection. The outbreak was associated with the consumption of curd pudding. The cook was found to carry the infection, and is presumed to be the source of the outbreak. In the Udmurtskaya Republic, 93 cases of acute dysentery were reported between April 24 andMay 1. This outbreak has been attributed to the water supply system, which became contaminated with sewage on April 23. The bacteriological strain, Shigella sonnei, was isolated from samples of 71 patients.
[PROMED 5/10/01]

GERMANY – IMPORTED VIRAL ENCEPHALITIS
A recent Pro–MED report describes a case involving a 23–year–old patient who developed an acute aseptic meningoencephalitis shortly after his return to Germany on April 27 after a six–month stay in Australia. The patient initially developed fever followed by evident behavioral changes and a persistent headache. He became comatose on May 4 and is currently under intensive care. The patient had been residing primarily in the Northern Territories and Queensland, where health officials have noted elevated risks of both Kunjin and Murray Valley Encephalitis, which are transmitted by the common banded mosquito, Culex annulirostris. Further test results are being conducted.
[PROMED 5/14/01]


2. UPDATES

ACUTE FEBRILE ILLNESS AMONG TRAVELERS TO MEXICO
The CDC and the Mexico Ministry of Health are continuing a joint investigation of the source of the outbreak of acute febrile illness that occurred in college students who recently visited Acapulco in March. Initial laboratory testing suggested that most of the students had histoplasmosis, an infection caused by the fungus Histoplasma capsulatum. The majority of students with the infection resided at the Calinda Beach Hotel in Acapulco. The CDC reports that as of May 1, 2001, 44 colleges in 22 states and the District of Columbia have reported 229 students with acute febrile respiratory illness who met a specified case definition. A cohort study of 109 randomly selected students who stayed at 3 different hotels in Acapulco during the first two weeks of March found that having stayed at the Calinda Beach Hotel was significantly associated with illness in univariate analysis. An investigation of the hotel and nearby areas in April did not identify any sources of the fungus. Another cohort study is currently being conducted among college students who stayed at the hotel during March to identify specific sources of infection. Reports of illness among travelers residing at the hotel in April are continuing to be received by the CDC, suggesting ongoing transmission associated with the hotel.
[MMWR 50;2001:359𤭘.
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5018a2.htm]


3. NOTICES

U.S. (CT) – SALMONELLOSIS LINKED TO CHEESE IN THE NORTHEAST
Fresh Italian–style cheese made by Liuzzi Cheese Co. in North Haven, CT, has been linked to at least 12 of 15 cases of Salmonellosis caused by the Salmonella newport strain. The Department of Public Health issued a recall on May 3 for basket cheese, ricotta cheese, and mozzarella cheese, all of which were made with unpasteurized milk. These cheeses were distributed throughout Connecticut and surrounding states and sold with a Liuzzi label beginning on approximately March 20. Consumers who bought the specified fresh cheese since March 20 are advised not to eat it and to inform the Department of Public Health if they still have some left. Salmonellosis is generally a self–limited infection, although it may become life–threatening in those at high risk, such as infants, the elderly, and immunocompromised individuals.
[PROMED 5/3/01]

U.S. – SALMONELLOSIS OUTBREAK NATIONWIDE FROM CANTELOUPES
An outbreak of Salmonellosis that has occurred in a number of states throughout the country has been attributed to cantaloupes that are thought to have been imported. The infection, caused by the rare strain Salmonella poona, killed a 78–year–old woman in California and caused illness in about 30 others in Arizona, Missouri, New Mexico, New York, Oregon, Tennessee, and Washington. All of the illnesses occurred between April 6 and April 24. Health officials have not identified the source of contamination that led to this outbreak, but an investigation is ongoing. Consumers are advised to wash their hands before and after preparing foods, and to rinse fruits and vegetables to remove bacteria.
[WA DEPT OF HEALTH 5/18/01; PROMED 5/16/01]

U.S. – GROUND BEEF RECALL
According to the Agriculture Department, Emmpack Foods Inc., of Milwaukee, WI, is recalling 471,000 pounds of ground beef as a result of possible contamination with the E. coli 0157:H7 bacteria. The meat was distributed across the country for retail use in five–pound tubes and for institutional purposes in boxes. Both bear a sell–by date of 3㪮㪙.
[PROMED 5/7/01]


4. JOIN THE E–LIST AND RECEIVE EINet NEWS BRIEFS REGULARLY
The APEC EINet listserv was established to enhance collaboration among academicians and public health professionals in the area of emerging infections surveillance and control. Subscribers are encouraged to share their material with colleagues in the Asia–Pacific Rim. To subscribe (or unsubscribe), please contactmailto:nwc@u.washington.edu. Further information about the APEC Emerging Infections Network is available at http://www.apec.org/infectious.

Revised:
Nov. 7, 2000

Contact us at apecein@u.washington.edu
© 2000, The University of Washington