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Vol. IV, No. 12 ~ EINet News Briefs ~ July 31, 2001


****A free service of the APEC Emerging Infections Network*****

The EINet listserv was created to foster discussion, networking, and collaboration in the area of emerging infectious diseases (EID's) among academicians, scientists, and policy makers in the Asia–Pacific region. We strongly encourage you to share their perspectives and experiences, as your participation directly contributes to the richness of the "electronic discussions" that occur. To respond to the listserv, use the reply function.


In this edition:

  1. Infectious disease information
  2. Updates
  3. Notices
  4. Journal Articles
  5. How to join the EINet listserv


1. OVERVIEW OF INFECTIOUS–DISEASE INFORMATION  
Below is a bi–monthly summary of Asia–Pacific emerging infectious diseases.

ASIA

PHILIPPINES – CIGUATERA FISH POISONING
An outbreak of suspected ciguatera fish poisoning (CFP) occurred in Navatos, Metro
Manila, infecting 50 individuals as of June 22. The 50 cases were linked to the
consumption of ciguatoxic barracuda. The Department of Health of the Philippines
notified the public and warned against eating large, carnivorous predator fish. The toxin
is produced by the Gambierdiscus toxicus microorganism and is consumed by reef fish,
which are subsequently eaten by predator fish. Ciguatoxic fish can appear and taste
normal, and cooking, drying, or freezing the fish will not destroy the ciguatera toxins.
Symptoms of the food poisoning include numbness of the extremities, diarrhea,
abdominal pain, chills, vomiting, and headaches. Outbreaks of CFP are predicted to
increase with rising fish exports from Pacific Island Nations.
[PROMED 7/7/01]

THAILAND – GOVERNMENT TO ENFORCE DENGUE FEVER CONTROL
MEASURES

The Thai government has imposed new measures intended to help curb the spread of
dengue fever, which caused 87 deaths and infected 43,699 individuals between Jan 1 and
June 30 of this year. The government plans to fine individuals whose homes or offices
are found to contain breeding sites for the Aedes mosquitoes, the vector responsible for
transmitting the infection. Aedes mosquitoes need clean, still water in order to breed. The
Deputy Health Minister stated that this measure is modeled after a successful method in
Singapore and is intended to encourage people to keep their areas free of the potential
breeding grounds. More than 700,000 volunteers were expected to initiate efforts to
destroy breeding sites throughout the country on July 9.
[PROMED 7/8/01]

SINGAPORE – RISE IN DENGUE CASES
According to the Environment Ministry (ENV), 892 cases of dengue fever were reported
in the first six months of this year, compared to 291 cases reported last year. The weekly
average number of cases for this year, 34, is approximately three times that of last year’s.
ENV officials are encouraging individuals to remove any stagnant water found on their
premises and to monitor their areas daily for potential breeding sites of the Aedes
mosquito.
[PROMED 7/12/01]


AMERICAS

U.S. (UTAH) – RESPIRATORY ILLNESS AMONG TRAIL VOLUNTEERS
Eight of 16 volunteers who worked on trails at the Dinosaur National Monument in late
June in Utah contracted a flu–like illness. Seven of the infected volunteers worked
primarily in an Indian sweat cave while the other volunteer worked on a quarter mile trail
that led to the cave. Health officials suspect that a soil–transmitted fungal pneumonia was
responsible for the infection. Volunteers who were infected came from different parts of
the country, including one from abroad, while volunteers from Utah and Colorado were
not affected.
[PROMED 7/6/01]

U.S. (OHIO) – SHIGELLOSIS OUTBREAK IN TODDLERS
Over 700 confirmed cases of shigellosis have been reported this year in Cincinnati and
Hamilton counties, with 539 of the cases occurring between June 1 and July 18 of this
year. In contrast, there were 574 confirmed cases in the same counties during all of 2000.
The majority of the cases have occurred in diaper–wearing toddlers, their family members, and their caregivers. The infection is highly contagious and is spread primarily through fecal–oral contact. Symptoms include diarrhea, fever, stomach cramps, and nausea. Ohio state law requires children with shigellosis to complete a five–day course of antibiotics, wait two days, and provide two clean stood samples before they are allowed to return to day care facilities. Health officials are reminding those who deal with infants and toddlers to be vigilant of the infection and to always wash their hands after changing diapers or helping children in the bathroom.
[THE CINCINNATI ENQUIRER 7/13/01, 7/18/01]

U.S. (TEXAS) – ANTHRAX OUTBREAK; HUMAN CASE
Hundreds of deer and several horses and cattle have died from probable anthrax disease
in south Texas, where health officials have reported one of the worst outbreaks of anthrax
since the late 1970’s. In addition, one human case of anthrax has been confirmed and
another is under investigation. This is the first human anthrax case in Texas since 1988.
The confirmed case is believed to have been exposed to the infection while vaccinating
goats. Health officials are urging ranchers, hunters, and others to avoid contact with dead
or sickly–looking animals. According to an epidemiologist with the Texas Department of
health, the safest way to handle infected dead animals is by burning their carcasses. The
area director for the Animal Health Commission has stated that he expects more cases
until cooler weather arrives.

Anthrax disease is caused by the spore–forming bacterium, Bacillus anthracis, and is most common in agricultural regions where it occurs in animals. Human cases often occur as a result of exposure to infected animals or their products. Anthrax can be treated effectively with antibiotics.
[PROMED 7/12/01; CDC, http://www.cdc.gov/ncidod/dbmd/diseaseinfo/anthrax_g.htm]


2. UPDATES

CHINA (HONG KONG) – H5 AVIAN INFLUENZA VIRUS IN WHOLESALE
CHICKEN

A dead chicken from a poultry wholesale market tested positive for the avian influenza
virus, H5, in early July. According to the Assistant Director of Agriculture, Fisheries, and
Conservation, there had not been any abnormal deaths of chickens at retail or wholesale
markets or any signs of sickness among chickens. Further analysis of the virus will
include gene sequencing in order to identify the specific type of virus. Authorities on
Mainland China were informed of the infection and have gone to the specified farm for
further investigation. Health authorities in Hong Kong have asked that farm not to export
live chickens into Hong Kong until further notice. As the avian influenza virus is
endemic in China, control measures are not intended to eliminate the virus, but rather to
help detect its presence before it causes an outbreak or mutates into a more dangerous
virus that could affect humans. These measures include surveillance and preventive
programs and a monthly “rest day,” during which markets can focus on cleaning.

In May of this year, the sale of live chickens was suspended for three weeks and over one
million chickens were slaughtered following an outbreak of the H5N1 virus that caused
chickens to die within days of being infected. While no humans were infected, health
authorities were concerned that the virus could combine with another virus that would
allow it to infect humans.
[PROMED 7/10//01]


3. NOTICES

UPCOMING REGIONAL HIV/AIDS EVENTS

  • HIV and Families: the 4th Australian Update on Pregnant Mothers, Infants, Children, and
    Families Living with HIV/AIDS
    August 9㪢, 2001 at the Sydney Children’s Hospital in New South Wales
    Email m.goode@unsw.edu.au
  • Counseling for Reproductive Health in Adolescence
    September 3㪦, 2001 at the Institute of Health Research in Bangkok, Thailand
    Email dnikorn@chula.ac.th
  • International Training Programme on Surveillance, Monitoring and Evaluation of
    HIV/AIDS Programmes
    September 17㪮, 2001 at the Indian Institute of Health Management Research in Jaipur, India
    Email iihmr@iihmr.org, rsgoyal@iihmr.org, or visit http://www.iihmr.org
  • Sixth International congress on AIDS in Asia and the Pacific: Breaking Down Barriers
    October 5㪢, 2001 at the Melbourne Convention and Exhibition Centre in
    Melbourne, Australia
    Email 6icaap@icms.com.au or visit http://www.icaap.conf.au/
  • 12th Asian–Pacific Regional Meeting of the International Union Against Sexually
    Transmitted Infections
    October 23㪳, 2001 in Beijing, China
    Email Dr. Ross Philpot at iusti@ozemail.com.au
  • Third International Pediatric Infectious Diseases Conference
    October 28㪶 in Monterey, CA, U.S.A.
    Email aweddle@idsociety.org
  • Eleventh STDs/AIDS Diploma Course
    November 5㪶, 2001 at the Bangrak Hospital in Bangkok, Thailand
    Email Dr. Verapol Chandeying at cverapol@ratree.psu.ac.th
  • Fifth International Conference on Home and Community Care for Persons Living with
    HIV/AIDS: Power of Humanity
    December 17㪬, 2001 at the Lotus Hotel Pang Suan Kaew in Chiang Mai,
    Thailand
    Email hiv2001@whothai.moph.go.th or visit http://www.hiv2001.com

COUNTRY REPORT OF HIV/AIDS IN INDONESIA
The Indonesian Health Department prepared a report on HIV/AIDS in the country in
advance of the United Nations General Assembly Special Session on HIV/AIDS
(UNGASS). The report states the basic principles of AIDS control in Indonesia,
describes the current situation and observed disease trends, and discusses lessons learned
and future actions. According to the report, Indonesia is considered a low–prevalence
country, but a number of factors create the potential for the infection to spread rapidly.
These factors include increasing rates of prostitution, domestic and international
migration, urbanization, tourism, poverty, and proximity to areas of higher prevalence.
Similarly, infection rates have increased in injection drug users in the past two years.
While the Ministry of Health has promoted condom use as a prevention measure,
particularly for high–risk populations, condom use remains a sensitive and controversial
issue in the general population. The report cites a 1999 UNAIDS statistic of 52,000 as an
estimate of the number of individuals infected with the virus, but the Indonesian Minister
of Health, in his speech at the UNGASS meeting, described the current total number of
cases of HIV as ranging from 80,000 to 120,000. The report and the speech are available
at http://www1.rad.net.id/aids/PosPaperUNGASS.doc and
http://www1.rad.net.id/aids/MinHealthSpeechUNGASS.txt, respectively.


POOR COUNTRIES TO RECEIVE FREE ACCESS TO MEDICAL JOURNALS
Medical schools, research laboratories, and government health departments in poor
countries will receive free electronic access to approximately 1,000 medical journals
under a program of the World Health Organization (WHO). The program is expected to
benefit about 600 institutions, primarily in Africa. The program stipulates that
institutions in countries where the per capita gross national product (GNP) is less than
$1,000 a year would receive the journals at no charge. Countries with a GNP between
$1,000 to $3,000 would be required to pay a minimal fee. The prohibitively high costs of
many journal subscriptions for libraries and research institutions have prevented many
developing countries from being able to access timely medical research information.
Currently, most medical schools in developing countries have access to fewer than 100
journals, while most American medical schools receive about 1,000 or more.
Participating publishers include Elsevier, Wolters Kluwer, Blackwell, Harcourt General,
Springer–Verlag, and John Wiley & Sons.
[THE WASHINGTON POST 7/9/01]

SARA LEE RECALLS 13,600 POUNDS OF BEEF AND HAM
Sara Lee Foods is recalling 13,600 pounds of sliced beef and ham products throughout
the country due to possible salmonella contamination. The company issued the recall on
July 18 following the report that one person became ill after eating the meat.
[ASSOCIATED PRESS 7/19/01]


4. JOURNAL ARTICLES

ADENOVIRUS –RELATED FATAL ILLNESSES
The Centers for Disease Control and Prevention (CDC) report on two case studies of fatal
adenovirus infections in previously healthy young adults shortly after their entry into the
Navy. From 1971 until 1996, all military recruits received oral, live enteric–coated
vaccines against adenovirus serotypes 4 and 7. In 1996, the manufacturer halted
production of adenoviral vaccines, which prompted the military to establish disease
surveillance for adenovirus–related illnesses. These case studies describe the first two
deaths associated with adenovirus infection following the unavailability of the vaccine.
According to the report, the first case initially presented with upper respiratory symptoms
and was prescribed azithromycin for bronchitis. He died nearly two weeks later from
complications of encephalitis. Postmortem serum specimens revealed a greater than
fourfold rise in neutralizing antibody titers to adenovirus types 4 and 7. The second case
initially presented with upper respiratory symptoms and later developed dyspnea,
weakness, and a petechial rash. He tested positive for group A streptococcus, and PCR
testing of lung tissue was positive for adenovirus DNA.

These cases demonstrate the severity of the complications that can result from adenovirus
infections and point to the need for ongoing surveillance efforts and continued vaccine
production. These cases also suggest that clinicians should be cognizant of the
possibility of adenovirus infection in young persons in the military who are severely ill.
[MMWR 2001;50:553𤰛,
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5026a1.htm]


5. JOIN THE E–LIST AND RECEIVE EINet NEWS BRIEFS REGULARLY
The APEC EINet listserv was established to enhance collaboration among academicians and public health professionals in the area of emerging infections surveillance and control. Subscribers are encouraged to share their material with colleagues in the Asia–Pacific Rim. To subscribe (or unsubscribe), please contactmailto:nwc@u.washington.edu. Further information about the APEC Emerging Infections Network is available at http://www.apec.org/infectious.

Revised:
June 21, 2001

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