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       Vol. IV, 
          No. 12 ~ EINet News Briefs ~ July 31, 2001  
        
       
  
      ****A free service of the 
        APEC Emerging Infections Network***** The EINet listserv 
        was created to foster discussion, networking, and collaboration in the 
        area of emerging infectious diseases (EID's) among academicians, scientists, 
        and policy makers in the AsiaPacific region. We strongly encourage you 
        to share their perspectives and experiences, as your participation directly 
        contributes to the richness of the "electronic discussions" that occur. 
        To respond to the listserv, use the reply function. 
         
       
 In this edition:  
      
        Infectious disease information   
        Updates
        Notices  
        Journal Articles  
        How to join the EINet listserv   
        
        
        
        
        
       1. OVERVIEW 
      OF INFECTIOUSDISEASE INFORMATION
 Below is a bimonthly summary of AsiaPacific emerging infectious diseases.
 
 
 ASIA 
         
 PHILIPPINES 
          – CIGUATERA FISH POISONINGAn outbreak of suspected ciguatera fish poisoning (CFP) occurred in 
          Navatos, Metro
 Manila, infecting 50 individuals as of June 22. The 50 cases were linked 
          to the
 consumption of ciguatoxic barracuda. The Department of Health of the 
          Philippines
 notified the public and warned against eating large, carnivorous predator 
          fish. The toxin
 is produced by the Gambierdiscus toxicus microorganism and is consumed 
          by reef fish,
 which are subsequently eaten by predator fish. Ciguatoxic fish can appear 
          and taste
 normal, and cooking, drying, or freezing the fish will not destroy the 
          ciguatera toxins.
 Symptoms of the food poisoning include numbness of the extremities, 
          diarrhea,
 abdominal pain, chills, vomiting, and headaches. Outbreaks of CFP are 
          predicted to
 increase with rising fish exports from Pacific Island Nations.
 [PROMED 7/7/01]
 THAILAND 
          – GOVERNMENT TO ENFORCE DENGUE FEVER CONTROL MEASURES
 The Thai government has imposed new measures intended to help curb the 
          spread of
 dengue fever, which caused 87 deaths and infected 43,699 individuals 
          between Jan 1 and
 June 30 of this year. The government plans to fine individuals whose 
          homes or offices
 are found to contain breeding sites for the Aedes mosquitoes, the vector 
          responsible for
 transmitting the infection. Aedes mosquitoes need clean, still water 
          in order to breed. The
 Deputy Health Minister stated that this measure is modeled after a successful 
          method in
 Singapore and is intended to encourage people to keep their areas free 
          of the potential
 breeding grounds. More than 700,000 volunteers were expected to initiate 
          efforts to
 destroy breeding sites throughout the country on July 9.
 [PROMED 7/8/01]
 SINGAPORE 
          – RISE IN DENGUE CASESAccording to the Environment Ministry (ENV), 892 cases of dengue fever 
          were reported
 in the first six months of this year, compared to 291 cases reported 
          last year. The weekly
 average number of cases for this year, 34, is approximately three times 
          that of last year’s.
 ENV officials are encouraging individuals to remove any stagnant water 
          found on their
 premises and to monitor their areas daily for potential breeding sites 
          of the Aedes
 mosquito.
 [PROMED 7/12/01]
 
  
          
        
           
 AMERICAS 
         
  
            U.S. 
              (UTAH) – RESPIRATORY ILLNESS AMONG TRAIL VOLUNTEERSEight of 16 volunteers who worked on trails at the Dinosaur National 
              Monument in late
 June in Utah contracted a flulike illness. Seven of the infected 
              volunteers worked
 primarily in an Indian sweat cave while the other volunteer worked 
              on a quarter mile trail
 that led to the cave. Health officials suspect that a soiltransmitted 
              fungal pneumonia was
 responsible for the infection. Volunteers who were infected came 
              from different parts of
 the country, including one from abroad, while volunteers from Utah 
              and Colorado were
 not affected.
 [PROMED 7/6/01]
 
 U.S. (OHIO) – SHIGELLOSIS OUTBREAK IN TODDLERS
 Over 700 confirmed cases of shigellosis have been reported this 
              year in Cincinnati and
 Hamilton counties, with 539 of the cases occurring between June 
              1 and July 18 of this
 year. In contrast, there were 574 confirmed cases in the same counties 
              during all of 2000.
 The majority of the cases have occurred in diaperwearing toddlers, 
              their family members, and their caregivers. The infection is highly 
              contagious and is spread primarily through fecaloral contact. Symptoms 
              include diarrhea, fever, stomach cramps, and nausea. Ohio state 
              law requires children with shigellosis to complete a fiveday course 
              of antibiotics, wait two days, and provide two clean stood samples 
              before they are allowed to return to day care facilities. Health 
              officials are reminding those who deal with infants and toddlers 
              to be vigilant of the infection and to always wash their hands after 
              changing diapers or helping children in the bathroom.
 [THE CINCINNATI ENQUIRER 7/13/01, 7/18/01]
 U.S. 
              (TEXAS) – ANTHRAX OUTBREAK; HUMAN CASEHundreds of deer and several horses and cattle have died from probable 
              anthrax disease
 in south Texas, where health officials have reported one of the 
              worst outbreaks of anthrax
 since the late 1970’s. In addition, one human case of anthrax has 
              been confirmed and
 another is under investigation. This is the first human anthrax 
              case in Texas since 1988.
 The confirmed case is believed to have been exposed to the infection 
              while vaccinating
 goats. Health officials are urging ranchers, hunters, and others 
              to avoid contact with dead
 or sicklylooking animals. According to an epidemiologist with the 
              Texas Department of
 health, the safest way to handle infected dead animals is by burning 
              their carcasses. The
 area director for the Animal Health Commission has stated that he 
              expects more cases
 until cooler weather arrives.
 Anthrax 
              disease is caused by the sporeforming bacterium, Bacillus anthracis, 
              and is most common in agricultural regions where it occurs in animals. 
              Human cases often occur as a result of exposure to infected animals 
              or their products. Anthrax can be treated effectively with antibiotics.[PROMED 7/12/01; CDC, http://www.cdc.gov/ncidod/dbmd/diseaseinfo/anthrax_g.htm]
 
  
       
 2. 
        UPDATES 
      CHINA (HONG 
        KONG) – H5 AVIAN INFLUENZA VIRUS IN WHOLESALE CHICKEN
 A dead chicken from a poultry wholesale market tested positive for the 
        avian influenza
 virus, H5, in early July. According to the Assistant Director of Agriculture, 
        Fisheries, and
 Conservation, there had not been any abnormal deaths of chickens at retail 
        or wholesale
 markets or any signs of sickness among chickens. Further analysis of the 
        virus will
 include gene sequencing in order to identify the specific type of virus. 
        Authorities on
 Mainland China were informed of the infection and have gone to the specified 
        farm for
 further investigation. Health authorities in Hong Kong have asked that 
        farm not to export
 live chickens into Hong Kong until further notice. As the avian influenza 
        virus is
 endemic in China, control measures are not intended to eliminate the virus, 
        but rather to
 help detect its presence before it causes an outbreak or mutates into 
        a more dangerous
 virus that could affect humans. These measures include surveillance and 
        preventive
 programs and a monthly “rest day,” during which markets can focus on cleaning.
 In May of this 
        year, the sale of live chickens was suspended for three weeks and over 
        one million chickens were slaughtered following an outbreak of the H5N1 virus 
        that caused
 chickens to die within days of being infected. While no humans were infected, 
        health
 authorities were concerned that the virus could combine with another virus 
        that would
 allow it to infect humans.
 [PROMED 7/10//01]
 
 
 3. 
        NOTICES 
      UPCOMING REGIONAL 
        HIV/AIDS EVENTS 
      
        HIV and Families: the 4th 
          Australian Update on Pregnant Mothers, Infants, Children, and Families Living with HIV/AIDS
 August 9㪢, 2001 at the 
          Sydney Children’s Hospital in New South Wales
 Email m.goode@unsw.edu.au
 
 
        Counseling for Reproductive 
          Health in AdolescenceSeptember 3㪦, 2001 at the Institute of Health Research in Bangkok, 
          Thailand
 Email dnikorn@chula.ac.th
 
        International Training 
          Programme on Surveillance, Monitoring and Evaluation of HIV/AIDS Programmes
 September 17㪮, 2001 at the Indian Institute of Health Management Research 
          in Jaipur, India
 Email iihmr@iihmr.org, rsgoyal@iihmr.org, 
          or visit http://www.iihmr.org
 
        Sixth International congress 
          on AIDS in Asia and the Pacific: Breaking Down BarriersOctober 5㪢, 2001 at the Melbourne Convention and Exhibition Centre 
          in
 Melbourne, Australia
 Email 6icaap@icms.com.au or 
          visit http://www.icaap.conf.au/
 
        12th AsianPacific Regional 
          Meeting of the International Union Against Sexually Transmitted Infections
 October 23㪳, 2001 in Beijing, China
 Email Dr. Ross Philpot at iusti@ozemail.com.au
 
        Third International Pediatric 
          Infectious Diseases ConferenceOctober 28㪶 in Monterey, CA, U.S.A.
 Email aweddle@idsociety.org
 
        Eleventh STDs/AIDS Diploma 
          CourseNovember 5㪶, 2001 at the Bangrak Hospital in Bangkok, Thailand
 Email Dr. Verapol 
          Chandeying at cverapol@ratree.psu.ac.th
 
        Fifth International Conference 
          on Home and Community Care for Persons Living with HIV/AIDS: Power of Humanity
 December 17㪬, 2001 at the Lotus Hotel Pang Suan Kaew in Chiang Mai,
 Thailand
 Email hiv2001@whothai.moph.go.th 
          or visit http://www.hiv2001.com
 COUNTRY REPORT 
        OF HIV/AIDS IN INDONESIAThe Indonesian Health Department prepared a report on HIV/AIDS in the 
        country in
 advance of the United Nations General Assembly Special Session on HIV/AIDS
 (UNGASS). The report states the basic principles of AIDS control in Indonesia,
 describes the current situation and observed disease trends, and discusses 
        lessons learned
 and future actions. According to the report, Indonesia is considered a 
        lowprevalence
 country, but a number of factors create the potential for the infection 
        to spread rapidly.
 These factors include increasing rates of prostitution, domestic and international
 migration, urbanization, tourism, poverty, and proximity to areas of higher 
        prevalence.
 Similarly, infection rates have increased in injection drug users in the 
        past two years.
 While the Ministry of Health has promoted condom use as a prevention measure,
 particularly for highrisk populations, condom use remains a sensitive 
        and controversial
 issue in the general population. The report cites a 1999 UNAIDS statistic 
        of 52,000 as an
 estimate of the number of individuals infected with the virus, but the 
        Indonesian Minister
 of Health, in his speech at the UNGASS meeting, described the current 
        total number of
 cases of HIV as ranging from 80,000 to 120,000. The report and the speech 
        are available
 at http://www1.rad.net.id/aids/PosPaperUNGASS.doc 
        and
 http://www1.rad.net.id/aids/MinHealthSpeechUNGASS.txt, 
        respectively.
 POOR COUNTRIES TO RECEIVE FREE ACCESS TO MEDICAL JOURNALS
 Medical schools, research laboratories, and government health departments 
        in poor
 countries will receive free electronic access to approximately 1,000 medical 
        journals
 under a program of the World Health Organization (WHO). The program is 
        expected to
 benefit about 600 institutions, primarily in Africa. The program stipulates 
        that
 institutions in countries where the per capita gross national product 
        (GNP) is less than
 $1,000 a year would receive the journals at no charge. Countries with 
        a GNP between
 $1,000 to $3,000 would be required to pay a minimal fee. The prohibitively 
        high costs of
 many journal subscriptions for libraries and research institutions have 
        prevented many
 developing countries from being able to access timely medical research 
        information.
 Currently, most medical schools in developing countries have access to 
        fewer than 100
 journals, while most American medical schools receive about 1,000 or more.
 Participating publishers include Elsevier, Wolters Kluwer, Blackwell, 
        Harcourt General,
 SpringerVerlag, and John Wiley & Sons.
 [THE WASHINGTON POST 7/9/01]
 SARA LEE RECALLS 
        13,600 POUNDS OF BEEF AND HAMSara Lee Foods is recalling 13,600 pounds of sliced beef and ham products 
        throughout
 the country due to possible salmonella contamination. The company issued 
        the recall on
 July 18 following the report that one person became ill after eating the 
        meat.
 [ASSOCIATED PRESS 7/19/01]
 
 
 4. 
        JOURNAL ARTICLES 
      ADENOVIRUS 
        –RELATED FATAL ILLNESSESThe Centers for Disease Control and Prevention (CDC) report on two case 
        studies of fatal
 adenovirus infections in previously healthy young adults shortly after 
        their entry into the
 Navy. From 1971 until 1996, all military recruits received oral, live 
        entericcoated
 vaccines against adenovirus serotypes 4 and 7. In 1996, the manufacturer 
        halted
 production of adenoviral vaccines, which prompted the military to establish 
        disease
 surveillance for adenovirusrelated illnesses. These case studies describe 
        the first two
 deaths associated with adenovirus infection following the unavailability 
        of the vaccine.
 According to the report, the first case initially presented with upper 
        respiratory symptoms
 and was prescribed azithromycin for bronchitis. He died nearly two weeks 
        later from
 complications of encephalitis. Postmortem serum specimens revealed a greater 
        than
 fourfold rise in neutralizing antibody titers to adenovirus types 4 and 
        7. The second case
 initially presented with upper respiratory symptoms and later developed 
        dyspnea,
 weakness, and a petechial rash. He tested positive for group A streptococcus, 
        and PCR
 testing of lung tissue was positive for adenovirus DNA.
 These cases demonstrate 
        the severity of the complications that can result from adenovirus infections and point to the need for ongoing surveillance efforts and 
        continued vaccine
 production. These cases also suggest that clinicians should be cognizant 
        of the
 possibility of adenovirus infection in young persons in the military who 
        are severely ill.
 [MMWR 2001;50:553𤰛,
 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5026a1.htm]
 
  
       
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