About

Bush Lab at Cascadia ProteomicsThe Bush Lab is a research group in the Department of Chemistry and the Biological Physics, Structure & Design Program at the University of Washington. Our research focuses on the development and application of mass spectrometry and ion mobility spectrometry techniques to elucidate the structures and assembly of protein complexes and subcellular machines.

  • Interested in joining the Bush Lab, click here.

Upcoming Talks: August 2015

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Prof. Bush is excited to present the following talks next month:

  • Korean Society for Mass Spectrometry Conference, Busan, Korea, 8/20/15.
  • POSTECH Ion Chemistry Mini-Symposium, Pohang, Korea, 8/17/15.
  • Young Chemists Symposium, IUPAC World Chemistry Congress, Busan, Korea, 8/14/15. (9:40-10:00 in Hall 107)
  • New Development in MS Fundamentals and Instrumentation Symposium, IUPAC World Chemistry Congress, Busan, Korea, 8/10/15. (11:35-11:55 in Hall 103)

Prof. Bush thanks the IUPAC-2015 Organizing Committee, the Korean Chemical Society, and the Korean Society for Mass Spectrometry for supporting various parts of this visit.

New Publication: Collision cross section calibrants for negative ion mode traveling wave ion mobility-mass spectrometry

malic_acid_tocCollision cross section calibrants for negative ion mode traveling wave ion mobility-mass spectrometryJay G. Forsythe, Anton S. Petrov, Chelsea A. Walker, Samuel J. Allen, Jarrod S. Pellissier, Matthew F. Bush, Nicholas V. Hud, Facundo M. Fernández. Analyst 2015, in press. (Link|PUBMED)

Abstract. Unlike traditional drift-tube ion mobility-mass spectrometry, traveling-wave ion mobility-mass spectrometry typically requires calibration in order to generate collision cross section (CCS) values. Although this has received a significant amount of attention for positive-ion mode analysis, little attention has been paid for CCS calibration in negative ion mode. Here, we provide drift-tube CCS values for [M − H] ions of two calibrant series, polyalanine and polymalic acid, and evaluate both types of calibrants in terms of the accuracy and precision of the traveling-wave ion mobility CCS values that they produce.

Congratulations to Rae Eaton, who was awarded an NSF Graduate Research Fellowship!

Rachael (Rae) Eaton, a first year graduate student in the Bush Lab, was recently awarded a National Science Foundation Graduate Research Fellowship! From the NSF:

The NSF Graduate Research Fellowship Program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering, and mathematics disciplines who are pursuing research-based Master’s and doctoral degrees at accredited United States institutions. (For additional information, click here.)

Upcoming Presentations: March/April 2015

Prof. Bush will present the following talks this Spring:

  • Colorado Mass Spectrometry Discussion Group, Colorado State University, Fort Collins, CO, 4/8/15. (Link)
  • Uppsala Conference on Electron Capture and Transfer Dissociation, Lake Arrowhead, CA, 3/22/15. (Link)
  • Triangle Area Mass Spectrometry Discussion Group, NC, 3/18/15. (Link)
  • Pittcon Conference, New Orleans, LA, 3/9/15. (Pittcon | Symposium)

Congratulations to Rae Eaton, who was selected to be a PNNL Graduate Fellow!

Rachael (Rae) Eaton, a first year graduate student in the Bush Lab, was one of three graduate students selected to be the first-ever PNNL Graduate Fellows! From the UW Department of Chemistry announcement:

The PNNL Graduate Fellowship Program provides recipients with valuable research experiences complementary to their graduate education at the University of Washington. This program was recently established by the Department of Chemistry and Pacific Northwest National Laboratory with the goal of generating new opportunities for collaboration, accelerating progress in research areas of mutual interest, and strengthening existing ties between the Department and PNNL.

Congratulations to Ken Laszlo!

ken_webpageCongratulations to Ken Laszlo, who just passed his General Exam and has advanced to candidacy!

Matthew Bush receives 2014 Eli Lilly Young Investigator Award in Analytical Chemistry

From UW Chemistry website (link):

Eli Lilly

Assistant Professor Matthew F. Bush has been selected to receive the 2014 Eli Lilly and Company Young Investigator Award in Analytical Chemistry. The award is given by the Analytical Chemistry Academic Contacts Committee at Eli Lilly and Company based upon Dr. Bush’s outstanding research, publication record, and the impact they feel he is making in the field of analytical chemistry.

Upcoming Presentations: November/December 2014

Prof. Bush will present the following seminars this Winter:

  • Department of Chemistry, University of Idaho, Moscow, ID, 12/2/14.
  • Department of Chemistry, Washington State University, Pullman, WA, 12/1/14.
  • Department of Chemistry, Western Michigan University, Kalamazoo, MI, 11/17/14.
  • Department of Chemistry, Kalamazoo College, Kalamazoo, MI, 11/17/14.
  • Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA, 11/10/14.
  • American Society for Mass Spectrometry Fall Workshop, Seattle, WA, 11/7/14. (Link)

Upcoming Presentations: September 2014

Prof. Bush will present the following seminars this September:

  • Department of Chemistry, Gustavus Aldolphus College, Saint Peter, MN. 9/26/14.
  • Minnesota Mass Spectrometry Discussion Group, University of Minnesota, Minneapolis, MN, 9/25/14. (Seminar at 7:00 PM at the Department of Food Science and Nutrition, Room 15, 1334 Eckles Ave., St. Paul, 55108.)
  • Department of Chemistry, Macalester College, Saint Paul, MN. 9/24/14.
  • Applications of Time of Flight Mass Spectrometry Meeting, Waters Co. / University of California at Los Angeles, Long Beach, CA, 9/15/14. (Link)
  • Proteomics Resource Seminar, University of Washington, Seattle, WA, 9/9/14.

MFB thanks the American Society for Mass Spectrometry Local Area Discussion Group Speaker Support Program for support for his trip to Minnesota.

Goodbye to Chrissy Stachl and Nora Munger

The Bush Lab says goodbye to Chrissy Stachl and Nora Munger. Chrissy recently graduated from the University of Washington as a Gates Millennium Scholar with a Bachelor of Science in Chemistry and Neurobiology. She will spend next year as a DAAD Scholar in the laboratory of Gert von Helden at the Fritz Haber Institute in Berlin. Nora Munger was an Amgen Scholar this summer and will return to Carleton College to complete degrees in Chemistry and Art History.