The Bush Lab is a research group in the Department of Chemistry and the Biological Physics, Structure & Design Program at the University of Washington. Our research focuses on the development and application of mass spectrometry and ion mobility spectrometry techniques to elucidate the structures and assembly of protein complexes and subcellular machines.
Most proteins, particularly those that accomplish complicated tasks, form assemblies with other proteins and molecules that are critical to their function. Established structural biology tools are most effective for highly purified samples that have limited conformational variability, which makes it challenging to apply those methods to capture a systems-wide understanding of the structures, interactions, and dynamics that are present under different cellular conditions. The Bush Lab develops and applies mass spectrometry based techniques that are fast, sensitive, and tolerant of heterogeneity for characterizing the native structures of biological assemblies.
The Bush Lab is excited to join the eScience Institute, which empowers researchers and students in all fields to answer fundamental questions through the use of large, complex, and noisy data. As the hub of data-intensive discovery on campus, the eScience Institute leads a community of innovators in the techniques, technologies, and best practices of …
Snow is rare in Seattle, which makes us appreciate it more than people in most places.
The Bush Lab welcomes Theresa Gozzo! To learn more about Theresa, click here.