About the Bush Lab

The Bush Lab is a research group in the Department of Chemistry and the Biological Physics, Structure & Design Program at the University of Washington. Our research focuses on the development and application of mass spectrometry and ion mobility spectrometry techniques to elucidate the structures and assembly of protein complexes and subcellular machines.

  • Interested in joining the Bush Lab? Click here to learn about current opportunities.
  • Our weekly group meetings are held on Tuesdays at 5:00 PM in CHL 068B.

Recent News

Congratulations to Evan Hubbard!

Congratulations to Evan Hubbard, who has accepted an offer to enter the Ph.D. program in Chemistry at the University of California, Riverside. As an undergraduate student researcher in the Bush Lab, Evan investigated fundamental aspects of electrospray ionization in the context of native mass spectrometry. We are excited to follow his research at UCR!

Research

Most proteins, particularly those that accomplish complicated tasks, form assemblies with other proteins and molecules that are critical to their function. Established structural biology tools are most effective for highly purified samples that have limited conformational variability, which makes it challenging to apply those methods to capture a systems-wide understanding of the structures, interactions, and dynamics that are present under different cellular conditions. The Bush Lab develops and applies mass spectrometry based techniques that are fast, sensitive, and tolerant of heterogeneity for characterizing the native structures of biological assemblies.