Ion mobility (IM) is a suite of technologies that leverages fundamental ion-neutral interactions, is complementary to mass spectrometry (MS), and shares the core strengths of sensitivity, selectivity, and speed. Seattle is home to a vibrant IM-MS community. The vision of Mobility Enabled Science in Seattle (MESS) is to leverage the expertise and resources of this community to advance the contributions of IM to the environmental, health, and physical sciences.
The next MESS meeting will be held at on Tuesday, February 19, 2019 at 5 pm in CHB 102.
(Hopefully not) Too Hot to Handle: the Internal Energies of Ions During IM
- Matt Bush will present a brief overview of the contemporary understanding of heating during ion mobility experiments.
Discussion: Multiplexing of Time-Dispersive IM Measurements
- We will discuss efforts by the IM community to improve the duty cycle of IM measurements.
- Before the meeting, participants should read “Pseudorandom Sequence Modifications for Ion Mobility Orthogonal Time-of-Flight Mass Spectrometry” by Clowers et al. LINK
MESS labs also participate in:
Ion Mobility of Proteins in Nitrogen Gas: Effects of Charge State, Charge Distribution, and Structure. Daniele Canzani, Kenneth J. Laszlo, Matthew F. Bush. J. Phys. Chem. A 2018, in press. (Link)
Characterization of the Mechanisms of Daptomycin Resistance among Gram-Positive Bacterial Pathogens by Multidimensional Lipidomics. Kelly M. Hines, Adam Waalkes, Kelsi Penewit, Elizabeth A. Holmes, Stephen J. Salipante, Brian J. Werth, Libin Xu. mSphere 2017, 2, DOI: 10.1128/mSphere.00492-17. (Link) Previous work suggests that altered lipid metabolism may be associated with daptomycin resistance in Gram-positive pathogens, but lipidomic changes underlying resistance are …
Effects of Charge State, Charge Distribution, and Structure on the Ion Mobility of Protein Ions in Helium Gas: Results from Trajectory Method Calculations. Kenneth J. Laszlo, Matthew F. Bush. J. Phys. Chem. A, 2017, 121, 7768–7777. (Link)