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File:Abstract Submission guidelines LA f .pdfCHARGE Consortium Wiki (Cohorts for Heart and Aging Research in Genomic Epidemiology)

Getting started

Unlike the CHARGE Consortium Public Website, this wiki requires a username and password to view most pages. To gain access, please fill-out the Request Account form; new user requests are reviewed by the Research Steering Committee approximately twice per month.

Once logged in, you can edit existing pages or Create a new page. Wikipedia has a nice tutorial on how to edit pages.

Consortium Documents (public, no login required)

• CHARGE Principles (pdf) : Principles for collaboration in the consortium, approved Jan 2008 by founding cohorts.
• CHARGE Working Group Principles (pdf) : Principles for collaboration in CHARGE working groups, new participants in working groups or CHARGE projects are asked to review and agree to these principles before joining.
• Aggregate Results-Sharing Principles : Guidelines for sharing results of GWAS, for participation in working groups and collaborative meta-analyses.
• Results Sharing Format : file format guidelines for sharing of aggregate results for meta-analysis.

Committees & Working Groups

• Research Steering Committee: Membership and minutes
• Analysis Subcommittee: Resources and references for doing analyses, and minutes of analysis calls

• CHARGE-S PAGE : The CHARGE Sequencing GWAS follow-up project
• Working Groups: Directory of phenotype working groups
• Results Sharing: Listing of file-sharing sites for each Working Group and contributing study, and details about CHARGE results sharing protocols

Consortium Information

• CHARGE Consortium : Public consortium website
• Logos : versions of the CHARGE Tiger, with some explanations of its origins.
• Consortium Overview: Overview for each cohort's genotyping, imputation, and funding acknowledgements.
• CHARGE Newsletters: Archive of the newsletters sent to everyone with a wiki account
• Grant information: Updates on CHARGE grant submissions
• CHARGE Publications: Last updated November 2010 (spreadsheet; PDF PubMed format)

Methods paper: Psaty BM, O'Donnell CJ, Gudnason V, Lunetta KL, Folsom AR, Rotter J.L., Uitterlinden AG, Harris TB, Witteman JCM, Boerwinkle E, on behalf of the CHARGE Consortium. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from five cohorts. Circ Cardiovasc Genet. 2009;2:73-80.

Investigator Meetings

Los Angeles/Redondo Beach, CA meeting: October 26-28 2011

The 2011 Fall CHARGE Investigator Meeting, hosted by the University of Washington and Cedars-Sinai Medical Center will be held at the Crowne Plaza Redondo Beach and Marina Hotel 300 N. Harbor Drive | Redondo Beach, CA 90277 on October 26-28, 2011.

Hotel reservations at1-888-233-9527 or online at the CHARGE Registration page . A block of rooms has been reserved for the 2011 Fall CHARGE Investigator Meeting at the rate of $149.00 (+tax) per night.

 Abstract/Poster Guidelines Deadline extended to October 14

Draft Agenda as of 10/1/11

Wednesday October 26, 2011

Adiposity WG

The Adiposity WG will hold a one-day meeting on Wednesday Oct 26 from 9:00 – 5:00 pm PT in conjunction with the CHARGE LA| Redondo Beach Investigator meeting. The Adiposity meeting is opened to all CHARGE investigators and meeting participants, and will be held at the same venue as the main meeting, the Crowne Plaza Redondo Beach and Marina Hotel. Please note registration is requested as lunch and refreshments will be served (register via the main CHARGE meeting registration web page– currently under construction). An agenda will be available prior to the meeting and will include project updates, methodology talks on pleiotropy, and planning for future projects. Drop-ins for any part of the program are welcome. If you have any questions, kindly contact Ingrid Borecki ingrid@dsgmail.wustl.edu  directly for details

CHARGE Steering Committee Dinner Meeting

7:00 - 9:00 TBD 

Working Group Meetings (scheduled as of 9/24)

4 - 5 Thyroid      R Peeters

4 - 6 DM           J Meigs
5 - 7 Neurology  S Seshadri
6 - 7 Pulmonary S London

Thursday October 27, 2011

8:00 – 8:10     Welcome – Jerome Rotter
8:10 - 8:25      State of CHARGE – Christopher O’Donnell

8:25 - 8:45      Bing Yu - Association of Genome-Wide Variation with Novel highly sensitive cardiac roponin-T (hs-cTnT) levels in adults of                           European and African Americans: A Meta-Analysis from ARIC and CHS
I. Functional Session

8:45 - 9:20      Jake Lusis Systems genetics and complex traits
9:20 – 9:55      David Rimoin Genetic Variants, Major Genes and Height
9:55 – 10:25    Break
10:25 – 10:45  Carla Ibrahim-Verbaas Development and Validation of Genetic Risk Prediction Scores for Stroke, Dementia and presence of MRI White Matter Hyperintensities
10:45-11:20    Jerome Rotter Inflammatory bowel disease GWAS to function and natural history
11:20 -11:55   Ulrich Broeckel Induced Pluripotent Stem Cell Technology for the Functional Analysis of GWAS Results

Lunch 11:55 – 1:00
Interactive | Discussion Session (Concurrent)
• Genomic Technology Andre Uitterlinden & Eric Boerwinkle
• Q & A Analysis Kenneth Rice and Thomas Lumley

II. Genomic Technologies Other than GWAS Session
1:00 – 1:20  Christy Avery - Drug-gene interactions and the search for missing heritability
1:20 – 1:55  Kari North Evaluation of the Metabochip Genotyping Array in Ancestrally Diverse Populations and Implications for Fine             Mapping of GWAS-Identified Loci

1:55 – 2:30  Kim Siegmund The power of DNA methylation microarrays

2:30 – 3:00  Break

3:00 - 3:35   Cornelia van Duijn From genome wide association to whole genome

CHARGE Analysis Committee Presentations

3:35 – 3:55  Colleen Sitlani Use of longitudinal analyses in genome-wide settings
3:55 – 4:15  Ingrid Borecki Methods for analysis of pleiotropy
4:15 – 4:35  Ken Rice Analysis of pharmacogenetic GxE interactions
4:35 – 5:00  Open Q & A J Rotter, B Psaty, C O’Donnell, C van Duijn
5:00 – 5:05  Bruce Psaty CHARGE Fellowship
5:05 - 7:00   Poster Reception
7:30 – 9:30  Group dinner – TBD

Friday October 28, 2011
8:00 – 12:00
8:00 – 8:05 Welcome – Jerome Rotter

III. Calling and imputing in the Genomic Era – Sequencing Era

8:05 - 8:25 Jennifer Wessel Genome-Wide Association Study of Clustering Of CVD Risk Factors: A Kannel-Stamler Analysis

8:25 - 9:00    Paul Scheet Imputation and rare variant calling
9:00 –9:35    Sharon Browning Analysis of rare variants
9:35 -10:10 Stephen Rich NHLBI Exome Sequencing Project and Exome Chip

10:10- 10:25 Break
10:25 -11:45 Eric Boerwinkle Sequencing Sessions

11:45 -12:00 Closing Remarks – Jerome Rotter
12:00 -1:00   Lunch

1:00 – 5:00 Working Group Meetings (scheduled as of 9/24)
7am – 8am AF             E Benjamin
1 - 2 Pharmaco            B Psaty
1 - 2 Entrepreneurship  A Hoffman
1 - 2 Musculoskeletal   D Kiel
1 - 2 Hemostasis         N Smith

2 - 3 BP                      G Ehret

2 - 3 ReproGen            J Murabito
3 - 4 Ed Attain             P Koellinger
3 - 4 Depression          J Murabito

Abstract/Poster Guidelines Deadline extended to October 14

Please contact Ann Walsh if you have any questions or suggestions.

Thank you, Ann Walsh  (walshac@nhlbi.nih.gov) on behalf of the CHARGE Steering Committee
508-663-4046

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Iceland Meeting: Date to be determined (May 2012)

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Past meetings (includes links to agendas and slides)

• Boston Meeting: February 9-11, 2011 hosted by Framingham
• Houston Meeting: April 28-30, 2010, hosted by ARIC
• Washington DC Meeting Oct 29-30, 2009
• Rotterdam Meeting: held 16-17 April 2009
• Seattle Meeting: held 9-11 July 2008
• Framingham Meeting: held 22-24 January 2008

Founding Cohorts

• Age, Gene, Environment Susceptibility (AGES)
• Atherosclerosis Risk in Communities Study (ARIC)
• Cardiovascular Health Study (CHS)
• Framingham Heart Study (FHS)
• Rotterdam Study (ERGO or RS)

Other Resources

• Consult the User's Guide or MediaWiki FAQ for information on using the wiki software.
• Please try to use text or online-viewable formats such as plain text or PDF whenever feasible. Ways of doing this include saving your document as HTML and then running it through html2wiki to get pasteable "wikitext" or using OpenOffice to export files into as MediaWiki format.
• Calendar: Editable calendar of ongoing calls (not currently updated)
• Time Zones: Useful information for setting up conference calls