Emerging Infections of International Public Health Importance

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MODULE 1:  
The Paradigm of Emergence

1.  Course Introduction and Overview of Emerging Infections
Ann Marie Kimball,  MD, MPH  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Executive summary (1-17), Ch 1 (19-22), skim Ch 3 (53-147)

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2.  Emerging Infectious Diseases; Worldwide and in the Americas
David Brandling-Bennett,  MD  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 4 (149-229)
     
  • Grein TW, Kande-Bure OK, Rodier G., et al. Rumors of disease in the global village: outbreak verification. Emerging Infectious Disease 2000, 6:97-102
     
  • WHO. A framework for global outbreak alert and response. WHO/CDS/CSR/2000.2
    http://www.who.int/csr/
     
  • WHO. Revision of the international health regulations; report by the secretariat. EB111/34, 15 December 2002.
    http://www.who.int/csr/ihr

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3.  Influenza
Kathleen Neuzil, MD, MPH  
 
  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 3 (136-147), Ch 4 (201-202)
     
  • Glezen WP. Emerging infections: pandemic influenza. Epidemiol Rev. 1996;18(1):64-76.
     
  • Claas EC, Osterhaus AD, van Beek R, De Jong JC, Rimmelzwaan GF, Senne DA, Krauss S, Shortridge KF, Webster RG. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet. 1998 Feb 14;351(9101):472-7.
     
  • Chiu SS, Lau YL, Chan KH, Wong WHS, Peiris M. Influenza-related hospitalizations in children in Hong Kong. N Engl J Med 2002;347.

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4.  Tuberculosis: Global Impact and Drug Resistance
Carrie Horwitch, MD, MPH  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 2 (23-41), Ch 3 (53-64, 116-130), Ch 4 (181-215)
     
  • White DG, Zhao S, Sudler R, Ayers S, Friedman S, Chen S, McDermott PF, McDermott S, Wagner DD, Meng J: The isolation of antibiotic-resistant salmonella from retail ground meats. N Engl J Med 2001 Oct 18;345(16):1147-54
     
  • Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, Dye C. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med. 2003 May 12;163(9):1009-21. Review.
     
  • Cosgrove SE, Carmeli Y. The impact of antimicrobial resistance on health and economic outcomes. Clin Infect Dis. 2003 Jun 1;36(11):1433-7. Epub 2003 May 16.

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MODULE 2:  
Current Challenges in Infectious Diseases

1.  Prions and Species Jumping
Marguerite Pappaioanou, DVM, PhD  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 3 (53-77, 106-109)
     
  • Belay ED, Maddox RA, Gambetti P, Schonberger LB. Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States. Neurology. 2003 Jan 28;60(2):176-81.
     
  • Prusiner SB. Shattuck lecture--neurodegenerative diseases and prions. N Engl J Med. 2001 May 17;344(20):1516-26. Review.
     
  • Will RG, Zeidler M, Stewart GE, Macleod MA, Ironside JW, Cousens SN, Mackenzie J, Estibeiro K, Green AJ, Knight RS. Diagnosis of new variant Creutzfeldt-Jakob disease. Ann Neurol. 2000 May;47(5):575-82.
     
  • Bosque PJ. Bovine spongiform encephalopathy, chronic wasting disease, scrapie, and the threat to humans from prion disease epizootics. Curr Neurol Neurosci Rep. 2002 Nov;2(6):488-95. Review.

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2.  Trade-related Infections
Ann Marie Kimball, MD, MPH  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 3 (88-106, 108-109, 128-129)
     
  • Kimball et al. Trade Related Infections-Global Traffic and Microbial Travel. Global Change and Human Health. EcoHealth. 2004 March. Volume 1, Number 1. Pages: 39 - 49

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3.  Bioterrorism
Col. Patrick Kelley, MD, DrPH  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 2 (46-51), Ch 3 (130-135), Appendix B (281-312)
     
  • Pavlin JA. “Epidemiology of bioterrorism.” Emerg Infect Dis, 1999 Jul-Aug; 5(4): 528-30.
    http://www.cdc.gov/ncidod/EID/vol5no4/pavlin.htm
     
  • Danzig R, Berkowsky PB. “Why should we be concerned about biological warfare?” JAMA, 1997; 278(5): 431-432.
     
  • Torok TJ, Tauxe RV, Wise RP, Livengood JR, Sokolow R, Mauvais S, Birkness KA, Skeels MR, Horan JM, Foster LR. “A large community outbreak of salmonellosis caused by intentional contamination of restaurant salad bars.”, JAMA, 278(5): 389-395.
     
  • Holloway HC, Norwood AE, Fullerton CS, Engel CC Jr, Ursano RJ. “The threat of biological weapons: prophylaxis and mitagation of psychological and social consequences.” JAMA, 1997; 278(5): 425-427. (optional)
     

Suggested/Additional Readings:

  • Gerberding JL, Hughes JM, Koplan JP: Bioterrorism preparedness and response: clinicians and public health agencies as essential partners. JAMA 287(7):898-900, 2002
     
  • Perkins, BA, Popovic T, Yeskey K: Public Health in the Time of Bioterrorism, Emerg Infect Diseases 8(10);1015-1018, October 2002
     
  • Recognition of Illness Associated with the Intentional Release of a Biologic Agent, MMWR 50(41);893-7, October 9, 2001
    http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5041a2.htm
     
  • Polyak CS, Macy JT, Irizarry-De La Cruz M, Lai JE, McAuliffe JF, Popovic T, et al. Bioterrorism-related anthrax: international response by the Centers for Disease Control and Prevention. Emerg Infect Diseases 8(10);1056-1059, October 2002
     
  • Buehler JW, Berkelman RL, Hartley DM, Peters CJ. Syndromic surveillance and bioterrorism-related epidemics. Emerg Infect Diseases 9(10);1197-1204, October 2003

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4.  West Nile Virus
Sharon G. Hopkins,  DVM, MPH  

Suggested/Additional Readings:

  • Lanciotti, RS et al. Origin of the West Nile Virus Responsible for an Outbreak of Encephalitis in the Northeastern United States. Science 286:2333-2337, 1999.
     
  • Emerging Infectious Diseases. Vol. 7, No. 4, July-August 2001. (Special focus issue on West Nile Virus)
    http://www.cdc.gov/ncidod/eid/vol7no4/contents.htm
     
  • Morse, DL. Perspective: West Nile Virus: Not a Passing Phenomenon. The New England Journal of Medicine 348:2173-74, 2003.
     
  • Hall, SS. On the Trail of the West Nile Virus. Smithsonian, July 2003.

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5.  HIV/AIDS
Carrie Horwitch, MD, MPH  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 2 (23-29), Ch 3 (58-59, 78-90, 127-130), Ch 4 (191-201)
     
  • Dixon S, McDonald S, Roberts J. The impact of HIV and AIDS on Africa's economic development. BMJ 2002;324:232-34.
     
  • von Schoen Angerer T, Wilson D, Ford N, Kasper T. Access and activism: the ethics of providing antiretroviral therapy in developing countries. AIDS 2001 Vol 15, suppl 5; S81-90.
     
  • Pisani E, Lazzari St, Walker N, Schwartlander B. HIV Surveillance: A global perspective. JAIDS 2003 Vol 32, suppl 1;ppS3-11.
     
  • Kitahata m, Tegger M, Wagner E, Holmes K. Comprehensive health care for people infected with HIV in developing countries. BMJ 2002;325:954-7.

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MODULE 3:  
Public Health Response

1.  Workup on the Unknown—Epi Investigations
Ann Marie Kimball,  MD, MPH  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 2 (23-51), Appendix B (281-312)
     
  • Rana A. Hajjeh, David Relman, Paul R. Cieslak, et al. Surveillance for unexplained Deaths and Critical Illnesses Due to possibly Infectious Causes, United States, 1995-1998, in Emerging Infectious Diseases from CDC vol. 8, No. 2 February 2002 http://www.cdc.gov/ncidod/EID/vol8no2/01-0165.htm
     
  • No Fair Warning: An Outbreak Following the 1999 Washington County Fair. Centers for Disease Control and Prevention. Epidemiology Program Office. Case Studies in Applied Epidemiology. No. 003-703

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2.  Workup on the Unknown—Lab Investigations
Romesh Gautom,  PhD  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 2 (23-51), Appendix C (313-329)
     
  • PulseNet: The Molecular Subtyping Network for Foodborne Bacterial Disease Surveillance, United States.  Bala Swaminathan et.al. Emerging Infectious Diseases, Vol. 7, No. 3, May-June 2001.
     
  • A Multistate Outbreak of Escherichia coli O157:H7-Associated Bloody Diarrhea and Hemolytic Uremic Syndrome From Hamburgers.  The Washington Experience.  Beth P. Bell et.al. JAMA, November 2, 1994-Vol 272, No.17.
     
  • Acute Infectious Diarrhea.  Nathan M. Thielman and Richard Guerrant. N Engl J MED 350;1 January 1, 2004.
     
  • Broadly Reactive and Highly Sensitive Assay for Norwalk-Like Viruses Based on Real-Time Quantitative Reverse Transcription-PCR. Tsutomu Kageyama et.al. Journal of Clinical Microbiology , Apr. 2003 p. 1548-1557

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3.  Malaria and Vaccine Development 
Gina Rabinovich,  MD  

  • Textbook Reading: Microbial Threats to Health: Emergence, Detection, and Response
    Ch 2 (24-25), Ch 3 (114-121), Ch 4 (174-229)
     
  • Rabinovitch, R. The Forgotten Epidemic. The Washington Post September 23, 2003
     
  • Rabinovitch, R. LIVES LOST This report concludes a series, begun on Jan. 26, on world health challenges and the solutions that are within reach.; AMID THE DEATH, NEW HOPE FROM EDUCATION TO VACCINES, A DRIVE TO HALT MALARIA TAKES OFF. The Boston Globe. December 28, 2003
     
  • Whittington D, Pinheiro AC, Cropper M. The Economics Benefits of Malaria Prevention: A Contingent Valuation Study in Marracuene, Mozambique. Journal of Health and Population in Developing Countries. 2003.
     
  • Dubovsky F, Rabinovich R., Malaria Vaccines. Chapter 47 in Vaccines, 4th Edition, Saunders Press, 2004

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4.  WHO Response—SARS and Emerging Infections
David Heymann,  MD  

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