University of Washington | Department of Immunology

Research in the Gale Laboratory is focused on understanding innate immunity to virus infection, the intracellular immune process and virus-host interactions that govern the viral replication and infection outcome. In addition to studying West Nile virus and human immunodeficiency virus, the laboratory is a component of the Hepatitis C virus Cooperative Research Centers supported by the NIH.

Recent Publications

Ramos, H.J., Lanteri, M.C., Blahnik, G., Negash, A., Suthar, M.S., Brassil, M.M., Sodhi, K., Treuting, P.M., Busch, M.P., Norris, P.J., Gale, M. Jr. (2012) IL-1B Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection. PLoS Pathog. 8:e1003039. PMID: 23209411

Lau, D.T., Negash, A., Chen, J., Crochet, N., Sinha, M., Zhang, Y., Guedj, J., Holder, S., Saito, T., Lemon, S.M., Luxon, B.A., Perelson, A.S., Gale, M. Jr. (2012) Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients With HCV Genotype 1 Infection. Gastroenterology. IN PRESS. PMID: 23123437

Wilkins, C., Woodward, J., Lau, D.T., Barnes, A., Joyce, M., McFarlane, N., Tyrrell, D.L., Gale, M. Jr. (2012) IFITM1 is a tight junction protein that inhibits hepatitis C virus entry. Hepatology. IN PRESS. PMID: 22996292

Schnell, G., Loo, Y-M., Marcotrigiano, J., Gale, M. Jr. (2012) Uridine composition of the poly-U/UC tract of HCV RNA defines non-self recognition by RIG-I. PLoS Pathogens. 8:e1002839. PMID: 22912574 PMCID: PMC3410852

Rustagi, A., Doehle, B.P., McElrath, J.M., Gale, M. Jr. (2012) Two new monoclonal antibodies for biochemical and flow cytometric analyses of human interferon regulatory factor-3 activation, turnover, and depletion. Methods. IN PRESS. PMID: 22705311

Liu, H.M., Loo, Y-M., Horner, S.M., Zornetzer, G.A., Katze, M.G., Gale, M. Jr. (2012) The Mitochondrial Targeting Chaperone 14-3-3e Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity. Cell Host Microbe. 11:528-537. PMID: 22607805

Horner, S.M, Liu, H.M., Park, H.S., Gale, M. Jr. (2012) Control of innate immune signaling and membrane targeting by the hepatitis C virus NS3/4A protease are governed by the NS3 helix α0.  J. Virology. PMID: 22238314

Horner, S.M, Liu, H.M., Park, H.S., Briley, J., Gale, M. Jr. (2011) Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. Proc. Natl. Acad. Sci. U.S.A. 108:14590-14595. PMID: 21844353 PMCID: PMC3167523

More Publications from the Gale Lab