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West Nile Virus West Nile virus has emerged across the Western hemisphere and North America. Our studies utilize in vitro and gene knockout mouse models to determine how West Nile virus modulates the innate immunity during infection. |
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West Nile Virus Transmission Cycle |
West Nile Virus Genome |
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West Nile and Dengue Virus Information: |
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| Research Projects: Cell-Specific Programs of Host Defense Against West Nile Virus This project has three major goals; the first is to define the IRF-specific and PRR-specific cellular responses against WNV. The second major goal of this project is to define the mechanisms by which IFN suppresses WNV RNA replication; and the final goal is to produce chimeric WNV strains with altered abilities to regulate IFN signaling. Immune Mechanisms of Flavivirus Control |