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Obesity and Body-Weight Regulation: Leptin Signaling in the Brain |
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Amieux and McKnight Science Signaling Perspectives BAT Differentiation |
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The RIIB KO mutation rescues the obesity of Agouti mice in studies conducted by Traci Czyzyk and Ama Sikorski in the lab.
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Two genetically lean mice weigh in on a scale with a genetically obese mouse. |
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Injection of AAV-CRE into the ventral medial hypothalamus of RIIbeta lox animals causes reexpression of RII in specific neurons. Linghai Yang is using this technique to determine what neurons require PKA-RIIbeta for regulation of energy balance and locomotor activity.
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AGRP-cre dependent expression of HA-tagged ribosomes in the hypothalamus is being developed by Paul Amieux for gene array analysis of specific neurons.
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Graduate student Katie Newhall measures a mouse's oxygen consumption as part of an effort to compare basal metabolic rate to body weight. |
In the News: Fat City, Part 2 (click here)
Skinny Mice Found to Offer Clue to Fat Human, New York Times (click here)
The mice that gorged -- and didn't gain weight, CNN (click here) |