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Projects Hormonal Control of Human Spermatogenesis
William J. Bremner, M.D., Ph.D., Principal Investigator
Dr. Bremner's research focuses on control factors in the male reproductive
system, including the roles of luteinizing hormone and
follicle-stimulating hormone in controlling testicular function, the
effects of androgens in men, and the effects of aging on the reproductive
system. Goals of this research include the development of an effective,
reversible hormonal contraceptive for men and the treatment of disorders
of spermatogenesis.
Role of Cyclic Nucleotide
Phosphodiesterases in Testis Function
Joseph A.
Beavo, Ph.D., Principal
Investigator
The Beavo lab is studying the action of
phosphodiesterase enzymes in the process of sperm activation and the role
of specific phosphodiesterase subtypes in sperm development and function.
http://depts.washington.edu/jbeavo/
http://depts.washington.edu/phcol/fac/beavo.html
Genetic Analysis of the Regulation and Execution of Spermatogenesis in
Mice
Robert E. Braun, Ph.D.,
Principal Investigator
Research projects are ongoing to study the genetic control
of germline stem cell maintenance, androgen regulation of
spermatogenesis, and posttranscriptional control of gene expression in
haploid spermatids.
http://www.gs.washington.edu/faculty/braun.htm
Role of cAMP and Ca2+ Dependent Protein Kinases in
Spermatogenesis
G. Stanley McKnight, Ph.D.,
Principal Investigator
The
McKnight lab investigates the functions of the protein kinase A regulatory
system in the mouse model and its role in control of energy balance and
glucose homeostasis, sperm motility, drug addiction, and neural
development.
http://depts.washington.edu/mcklab/
Sertoli Cell Function
Michael D. Griswold, Ph.D., Principal Investigator
Dr. Griswold investigates the
influence of Sertoli cells on the process of germinal cell differentiation
and maturation, and specifically the action of glycoproteins secreted by
these cells.
http://www.wsu.edu/~crb/3FacultyPages/Griswold.html
Signaling Biophysics of Reproductive Cells
Bertil Hille, Ph.D.,
Principal Investigator
The Hille lab is
studying the mechanisms involved in cell signaling by ion channels,
neurotransmitters, and hormones acting through G-protein coupled receptors
and intracellular calcium.
http://depts.washington.edu/pbiopage/faculty/hille.html
Brain Genes Governing Reproduction
Robert A. Steiner, Ph.D., Principal Investigator
Research in this
lab is directed toward understanding the neuroendocrine mechanisms
governing reproduction, with focus on the regulation of neuropeptides,
their receptors, and intracellular signaling pathways involved in the
control of gonadotropin secretion and body-weight regulation.
http://depts.washington.edu/pbiopage/faculty/steiner.html
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