| The lab is organized into four major research groups focusing on the study of: |
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The effect of bacterial type III effector proteins on mammalian cells |
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The assembly and regulation of the type III secretion system of Salmonella typhimurium, which translocates proteins into mammalian cells on contact |
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The environmental remodeling of the gram-negative bacterial surface that occurs when bacteria infect host tissues |
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The characterization of the phenotypic adaptation of Pseudomonas aeruginosa to the unique environmental niche of the CF airway |
| Current projects within each group include the study of: |
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Salmonellae translocated effectors (which are delivered across the phagosome membrane and recruited to the actin cytoskeleton) and the mechanism of translocation of the Yersinia virulence effector YopM to the nucleus
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Assembly of the type III secretion system inner membrane ring of the needle complex and structure-function analysis of the type III secretion chaperone InvB |
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Remodeling of the surface of lipid A after bacterial infection of host tissues and analysis of the recognition of CF-unique lipid A by human Toll-like receptor 4 |
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Proteomic analysis and transcriptional profiling of Pseudomonas aeruginosa isolated from asymptomatic infants with CF and Pseudomonas colonization |
