Welcome to the Stoll lab!

Our principal focus is advanced Electron Paramagnetic Resonance (EPR) spectroscopy, a set of techniques that allows us to measure molecules with unpaired electrons such as organic radicals and transition metal ions and learn about their structure and nano-environment. EPR is similar to NMR spectroscopy, but uses unpaired electrons instead of magnetic nuclei.

Our research program has two areas of activity: (1) structure and function of proteins, (2) EPR methods development.

(1) Using DEER spectroscopy, a type of EPR that measures nanoscale distances between unpaired electrons, we study the structure and dynamics of proteins, in order to understand how they function and how they are regulated. Current projects involve ion channels and the spike protein of SARS-CoV 2.

(2) We develop new cutting-edge EPR spectroscopy methods, with the goal of improving sensitivity and resolution. For this, we build new instruments, develop new excitation schemes, conceive new data analysis approaches, and devise new quantum simulation methods. These advances allow is to study smaller and smaller samples, with lower concentrations of unpaired electrons.

Our research covers areas in spectroscopy, experimental and theoretical physical chemistry, biophysics, and bioinorganic chemistry.

We are part of the Department of Chemistry at the University of Washington in Seattle, USA.