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Welcome to the Stoll lab!

Our principal focus is advanced Electron Paramagnetic Resonance (EPR) spectroscopy, a set of techniques that allows us to measure molecules with unpaired electrons such as organic radicals and transition metal ions and learn about their structure and nano-environment. EPR is similar to NMR spectroscopy, but uses unpaired electrons instead of magnetic nuclei.

Our research program has two areas of activity: (1) EPR methods development, and (2) applications to systems of biological relevance.

(1) We develop new cutting-edge EPR spectroscopy methods, with the goal of improving sensitivity and resolution. For this, we build new instruments, develop new excitation schemes, conceive new data analysis approaches, and devise new quantum simulation methods. These advances allow is to study smaller and smaller samples, with lower concentrations of unpaired electrons.

(2) We use advanced EPR spectroscopy to examine how Nature works on the nanoscale. Using DEER spectroscopy, a type of EPR that measures nanoscale distances between unpaired electrons, we study the conformational landscapes of proteins, in order to understand how they function and how they are regulated. Using hyperfine spectroscopy (ENDOR and ESEEM), a set of EPR techniques that measure couplings between an unpaired electron and surrounding magnetic nuclei, we study the structure of enzyme active sites, with the goal of understanding their reactivity.

Our research covers areas in spectroscopy, experimental and theoretical physical chemistry, biophysics, and bioinorganic chemistry.

We are part of the Department of Chemistry at the University of Washington in Seattle, USA.