Metallo- and radical enzymes
Many of the most difficult and complex chemical transformations in nature make use of redox or radical chemistry. Enzymes use transition metal ions, metal ion clusters, and very reactive organic radicals in their catalytic centers to perform difficult substrate transformations. Many of these reactions are essential to life, and some of them are pathologically relevant. We study the structural and dynamic details of these reactions to understand how these reactive paramagnetic intermediates are generated, harnessed and controlled.