TLC-ART Program

TLC-ART’s DcNP^a Platform Validation

TLC-ART’s innovative technology has now been validated to enable to produce long-acting, targeting multiple drugs simultaneously to HIV-host cells, & to allow a single-dose to carry 3-4 drugs. The following boxes demonstrate platform capabilities and validation.

3-Drug Combo^b: LPV/RTV/TFV

3 drugs in 1 nano-dosage
One SQ dose last for 2+ wk
HIV host cells > plasma drugs
Lymph cells > PBMC^c

Recent developments of nanotherapeutics for targeted and long-acting, combination HIV chemotherapy.

Mechanism-based pharmacokinetic (MBPK) models describe three antiretrovirals delivered a long-acting anti-HIV drug combination nanoparticle formulation.

Long-acting combination anti-HIV drug suspension enhances & sustains higher drug levels in lymph node cells than in blood cells and plasma.

Anti-HIV drug-combination nanoparticles enhance plasma exposure as well as triple-drug combination levels in cells within lymph nodes & blood.

4-Drug Combo^b: LPV/RTV/3TC/TFV

4 drugs in 1 nano-dosage
One SQ dose last for 2+ wk
HIV host cells > plasma drugs
Lymph cells > PBMC^c

Long-acting combination anti-HIV drug enhances & sustains higher drug levels in lymph nodes than in blood cells & plasma.

Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Injection.

3-Drug Combo^b: ATV/RTV/TFV

3 drugs in 1 nano-dosage
One SQ dose last for 2+ wk
HIV host cells > plasma drugs
Lymph cells > PBMC^c

Three HIV Drugs Exhibit Long-Acting and Lymphocyte-Targeting Properties in Nonhuman Primates.

3-Drug Combo^b: LPV/EFV/TFV

3 drugs in 1 nano-dosage
One SQ dose last for 2+ wk
HIV host cells > plasma drugs
Lymph cells > PBMC^c

Extended cell and plasma drug levels after one dose of a 3-in-1 nanosuspension containing lopinavir, efavirenz, and tenofovir in non-human primates.

_{a, DcNP; Drug combination Nano-Particle platform developed by the TLC-ART Program}

_{b, LPV, Lopinavir; RTV, Ritonavir; 3TC, Lamivudine; EFV, Efavirenz; TFV, Tenofovir}

_{c, PBMC found in the blood that can be HIV infected}