We use a wide variety of spectroscopic and analytical techniques in the course of our research. We own a Fluorolog Tau-3 frequency-domain instrument for time-resolved fluorimetry, as well as two SLM/Aminco steady-state fluorimeters (an AB-2 and an 8100) and an Applied Photophysics SX.18MV-R for stopped-flow fluorescence and absorbance measurements. We also own two Waters HPLC systems for analytical and preparative purposes.
We share a number of instruments with the rest of the Medicinal Chemistry Department, including a Varian 500 MHz Unity Inova NMR, absorbance spectrophotometers (an Olis Modernized Aminco DW-2 and a Cary 3E), and facilities for protein expression in bacterial and insect-cell systems.
We have access to several mass spectrometry instruments via the Department's Mass Spectrometry Center, as well as several additional NMR instruments (a 750 MHz, a 500 MHz, and two 300 MHz) via the Dept. of Chemistry NMR facility. For surface plasmon resonance experiments, we use a Biacore 2000 in the Dept. of Physiology & Biophysics, and we also have access to nanoscale characterization and fabrication tools (atomic force microscopy, electron microscopy and confocal fluorescence microscopy) at the Nanotech User Facility and the Dept. of Pathology EM Center.