Ti Li has a third story on the DDB1-Cul4A ubiquitin ligase complex.
December 10,2009
In collaboration with Dr. Michel Strubin in Switzerland, Ti Li has identified a hidden helical motif in DCAFs, the substrate receptor subunits of the DDB1-Cul4A-Rbx1 ubiquitin ligase machinery. This motif is also found in the X protein of the hepatitis B virus, which binds DDB1 and possibly hijacks the host E3 complex to benefit viral replication. Ti's work was published in Nature Structural and Molecular Biology.