Recent publications
Tan X and Zheng N 2009. Hormone signaling through protein destruction: a lesson from plants. Am J Physiolo Endocrinol Metab. 296:E223-7.
Saifee NH and Zheng N 2008. A ubiquitin-like protein unleashes ubiquitin ligases. Cell 135:209-211 (Preview).
Hayashi K, Tan X, Zheng N, Hatate T, Kimura Y, Kepinski S, Nozaki H. 2008. Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. PNAS 105:5632-7.
Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras A, Zheng N, MacCoss MJ, Angers S, and Moon RT. 2007. Wilms Tumor Suppressor WTX Negatively Regulates Wnt/b-Catenin Signaling. Science 316:1043-1046.
Tan X, Calderon-Villalobos LIA, Sharon M, Zheng C, Robinson CV, Estelle M, and Zheng N 2007. Mechanism of Auxin Perception by the TIR1 Ubiquitin Ligase. Nature 446:641-645 (Cover Story).
Angers S, Li T, Yi X, MacCoss MJ, Moon RT, and Zheng N 2006. Molecular Architecture and Assmebly of the DDB1-Cul4A Ubiquitin Ligase Machinery. Nature 443:590-593 (doi:10.1038/nature05175).
Li T, Chen X, Garbutt KC, Zhou P, and Zheng N 2006. structure of DDB1 in complex with a Paramyxovirus V protein: Viral Hijack of A propeller cluster in ubiquitin ligase. Cell 124:105-117.
Chen H, Shen Y, Tang X, Yu L, Wang J, Guo L, Zhang Y, Zhang H, Feng S, Strickland E, Zheng N, Deng XW. 2006 Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. Plant Cell. 18:1991-2004.
Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, Maccoss MJ, and Moon RT 2006. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol 8:348-357.
Chen X, Zhang J, Lee J, Lin PS, Ford JM, Zheng N and Zhou P 2006. A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins. Mol Cell 22:489-499.
Martinez SE, Bruder S, Schultz A, N. Zheng. Schultz JE, Beavo JA, Linder JU. 2005. Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization. PNAS 102:3082-3087.
Bruder S, Linder JU, Martinez SE,, N. Zheng. Beavo JA, Schultz JE. 2005. The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. PNAS 102:3088-3092.
Li T, Pavletich NP, Schulman BS, and Zheng N 2005. High-Level Expression and Purification of Recombinant SCF ubiquitin Ligases. Ed. Raymond J. Deshaies. Methods in Enzymol 398: 125-142.
Goldenberg SJ, Cascio TC, Shumway SD, Garbutt KC, Liu J, Xiong Y, and Zheng N 2004. Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases. Cell 119: 517-528.
Zhang J, Zheng N, Zhou P 2003. Exploring the functional complexity of cellular proteins by protein knockout. PNAS 100:14127-14132.
Zheng N 2003. A Closer Look at the HECTic Ubiquitin Ligases. Structure 11: 5-6 (Preview).