Jay T. Rubinstein, M.D., Ph.D.

Professor and Director rubinj@u.washington.edu

Department of Otolaryngology - HNS, Virginia Merrill Bloedel Hearing Research Center

Dr. Rubinstein has expertise in neural stimulation and processing of sensory stimuli for neual prostheses.  In addition, he is an expert on the successful application of these techniques to enhanced auditory prostheses.  Also, Dr. Rubinstein is an otlogic surgeon with special expertise in the implantation of stimulating electrodes in the inner ear.  Dr. Rubinstein will supervise the implementation and surgical implantion of the stimulating electrodes, includineg the chronic prosthesis.  In addition, he is working with our corporate partners to optimize the design of a miniaturized fully implantable vestibular electrode array and processor.  Dr. Rubinstein will also work with Dr. Kaibao Nie to implement the novel processing strategies proposed in this project.

Education (top) ±

  • 1981 - B.S., Engineering :: Brown University, Providence, RI
  • 1983 - M.S., Engineering :: Brown University, Providence, RI
  • 1988 - M.D., Medicine :: University of Washington, Seattle, WA
  • 1987 - Ph.D., Bioengineering :: University of Washington, Seattle, WA

Internships and Residencies:

  • 1988-1989 - Intern (Surgery) :: Beth Israel Hospital, Boston, MA
  • 1990-1994 - Resident (Otolaryngology) :: Massachusetts Eye and Ear Infirmary, Boston, MA

Clinical and Research Fellowships:

  • 1988 - Research Fellow, Departmet of Physiology and Biophysics
    University of Washington, Seattle, WA
  • 1989-1990 - Research Fellow, Department of Otology and Laryngology
    Harvard Medical School
  • 1994-1995 - Clinical Fellow in Otology/Neurotology, Department of Otolaryngology
    The University of Iowa Hospitals and Clinics, Iowa City, IA

Specific and Technical Accomplishments (top) ±


  • 1981 - Honorary Undergraduate Teaching Assistantship
  • 1981 - Sigma Xi
  • 1984-1986 - Poncin Scholarship Award
  • 1987 - Alpha Omega Alpha
  • 1992 - American Academy of Otolaryngology Resident Research Grant
  • Beorhaave Professor, Leiden University, the Netherlands

Recent Publications (top) ±

White JA, Rubinstein JT, Kay AR.  Intrinsic noise in neurons. Trends in Neuroscience 23:131-137, 2000.

Wang G, Skinner MW, Rubinstein JT, Howard MA, Vannier MW: Digital X-ray stereophotogrammetry for cochlear implantation. IEEE Transactions on Biomedical Engineering, 47 (8) 1120-1130, 2000.

Matsuoka AJ, Abbas PJ, Rubinstein JT, Miller CA.  The neuronal response to electrical constant-amplitude pulse train stimulation: evoked compound action potential recordings.  Hearing Research, 149, 115-128, 2000.

Matsuoka AJ, Abbas PJ, Miller CA, Rubinstein JT.  The neuronal response to electrical constant-amplitude pulse train stimulation: additive Gaussian noise.  Hearing Research, 149 , 129-137, 2000.

Tyler RS, Parkinson A, Wilson B, Parkinson W, Lowder M, Witt S, Rubinstein J, Gantz B.  Evaluation of different choices of n in an n-of-m processor for cochlear implants.  Adv Oto-Rhino- Laryn 57, 311-315, 2000.

Yoo SK, Wang G, Rubinstein JT, Vannier MW. Three-dimensional geometric modeling of the cochlea using helico-spiral approximation. IEEE Transactions on Biomedical Engineering  47 (10) 1392-1402, 2000

Miller CA, Robinson BK, Rubinstein JT, Abbas PJ, Samuelson CR Auditory nerve response to monophasic and biphasic electric stimuli.  Hearing Research 151, 79-94, 2001.

Matsuoka AJ, Rubinstein JT, Abbas PJ, Miller CA.  The effects of interpulse interval on stochastic properties of electrical stimulation models and measurements. IEEE Transactions on Biomedical Engineering, Vol 48, No 4, 416-424, April 2001.

Lustig, LR, Arts HA, Brackmann DE, Francis HF, Molony T, Megerian CA, Moore GF, Moore KM,
Rubinstein JT, Miller CA, Mino H, Abbas PJ.  Analysis of monophasic and biphasic electrical stimulation.  IEEE Transactions on  Biomedi-cal Engineering 48(10): 1065-1070, 2001.

Mino H, Rubinstein JT, White JA. Comparison of algorithms for the simulation of action potentials with stochastic sodium channels. Annals of Biomedical Engineering 30(4): 578-587, 2002.

Rubinstein JT and Turner CW.  A novel acoustic simulation of cochlear implant hearing: effects of temporal fine structure. First International IEEE EMBS Conference on Neural Engineering, IEEE press, 142-145, 2003.

Rubinstein JT, Tyler RS, Wolaver A and Brown CJ.  Electrical suppression of tinnitus with high-rate pulse trains. Otology & Neurotology, 24: 478-485, 2003.

Hong RS, Rubinstein JT, Wehner D, Horn D.  Dynamic range enhancement for cochlear implants. Otology & Neurotology, 24: 590-595, 2003.

Rubinstein JT and Della Santina CC.  Analysis of a biophysical model for vestibular prosthesis research.  Journal of Vestibular Research 12(2-3): 69-76, 2003.

Rubinstein JT, Hong RS.  Signal coding in cochlear implants: Exploiting stochastic effects of electrical stimulation.  Annals of Otology, Rhinology and Laryngology 112(suppl 191): 14-19, 2003.

Hong RS and Rubinstein JT. High-rate conditioning pulse trains in cochlear implants:  Dynamic range measures with sinusoidal stimuli.  Journal of the Acoustical Society of America 114(6): 3327-3342, 2003.

Mino H, Rubinstein JT, Miller CA, Abbas PJ.  Effects of electrode-to-fiber distance on temporal jitter with electrical stimulation. IEEE Transactions on Biomedical Engineering 51(1): 13-20, 2004.

Yoo SK, Wang G, Collison F, Rubinstein JT, Vannier MW, Kim HJ, Kim NH.  Three-dimensional localization of cochlear implant electrodes using epipolar stereophotogrammetry. IEEE Transactions on Biomedical Engineering 51(5): 838-846, 2004.

Runge-Samuelson CL, Abbas PJ, Rubinstein JT, Miller CA, Robinson BK.  Response of the auditory nerve to sinusoidal electrical stimulation: effects of high-rate pulse trains. Hearing Research 194(1-2):1-13, 2004.

Patents (top) ±

Jay T Rubinstein.  Pseudospontaneous Neural Stimulation System and Method.  U.S. Patent No. 6,078,838.   6/20/00.

Jay T Rubinstein, Carolyn J Brown, Richard S Tyler, Paul J Abbas. System and Method for Application of Pseudospontaneous Neural Stimulation. U.S. Patent No. 6,295,472, 9/25/01.

Jay T Rubinstein, Carolyn J Brown, Richard S Tyler.  System and Method for Diagnosing and/or Reducing Tinnitus. U.S. Patent No. 6,631,295, 10/7/03.

Jay T Rubinstein, Blake S Wilson.  Speech Processing System and Method Using Pseudospontaneous Stimulation.  Filed February, 1999.

Grants/Contracts (top) ±

Rubinstein, JT, Principal Investigator
Biophysical Model ofType - I Spiral Ganglion Cells                                                                              
The Whitaker Foundation

NO1-R55 DC/ODO2948-01 – Rubinstein, JT, Principal Investigator
Comparative Biophysical Model of Spiral Ganglion Cells                                   
National Institutes of Health, Shannon Award

N01-DC-6-2111 – Rubinstein, JT, Co-Principal Investigator
The Neurophysiological Effects of Simulated Auditory Prosthesis Stimulation                       
National Institutes of Health

SBIR R43DC03505 – Rubinstein, JT, Subcontract Principal Investigator
Cochlear Electrode with High Channel Selectivity
National Institutes of Health

NIH-DC-98-14 –          
The Neurophysiological Effects of Simulated Auditory Prosthesis Stimulation
National Institutes of Health              
NIH-DC-98-11 - Rubinstein, JT, Co-Investigator         
Effects of Remaining Hair Cells on Cochlear Implant Function
National Institutes of Health

Rubinstein, JT, Principal Investigator  
Ear Implant for Tinnitus Suppression
Braintronics, Inc           

Rubinstein, JT, Principal Investigator          
Dynamic range with high-rate conditioning stimuli
Advanced Bionics Inc.

Rubinstein, JT, Principal Investigator
Frequency discrimination with high-rate conditioning stimuli           
Advanced Bionics Inc.

DC05972 - Rubinstein, JT, Investigator           
Randomized Trial of Tinnitus Retraining Therapy
National Institutes of Health