Harwood Lab masthead
School of MedicineUniversity of Washington • Box 357735 • 1705 NE Pacific St • Seattle WA 98195
  Harwood Lab: Regulation of photosynthesis    

One of the simplest forms of photosynthesis, termed cyclic photophosphorylation, is carried out by the bacterium Rhodopseudomonas. Rhodopseudomonas generates energy from light under anaerobic growth conditions and it can modulate the components of its photosynthetic apparatus in response to low light. How does it sense low light? Rhodopseudomonas has light-sensing proteins called bacteriophytochromes. Our goal is to provide a first complete biochemical and physiological characterization of a bacteriophytochrome-initiated signal transduction cascade for gene regulation in response to low light. Bacteriophytochromes are important in optogenetics, which uses photosensory proteins to control functions in whole animals in response to light.

  Figure 1.1