Jaisri Lingappa's Lab

Jaisri Lingappa’s Publications

  1. Michon, M, Müller-Schiffmann, A, Lingappa, AF, Yu, SF, Du, L, Deiter, F, Broce, S, Mallesh, S, Crabtree, J, Lingappa, UF, Macieik, A, Müller, L, Ostermann, PN, Andrée, M, Adams, O, Schaal, H, Hogan, RJ, Tripp, RA, Appaiah, U, Anand, SK, Campi, TW, Ford, MJ, Reed, JC, Lin, J, Akintunde, O, Copeland, K, Nichols, C, Petrouski, E, Moreira, AR, Jiang, IT, DeYarman, N, Brown, I, Lau, S, Segal, I, Goldsmith, D, Hong, S, Asundi, V, Briggs, EM, Phyo, NS, Froehlich, M, Onisko, B, Matlack, K, Dey, D, Lingappa, JR, Prasad, DM, Kitaygorodskyy, A, Solas, D, Boushey, H, Greenland, J, Pillai, S, Lo, MK, Montgomery, JM, Spiropoulou, CF, Korth, C, Selvarajah, S, Paulvannan, K, Lingappa, VR. A pan-respiratory antiviral chemotype targeting a transient host multi-protein complex. Open Biol. 2024;14 (6):230363. doi: 10.1098/rsob.230363. PubMed PMID:38889796 .
  2. Michon, M, Müller-Schiffmann, A, Lingappa, AF, Yu, SF, Du, L, Deiter, F, Broce, S, Mallesh, S, Crabtree, J, Lingappa, UF, Macieik, A, Müller, L, Ostermann, PN, Andrée, M, Adams, O, Schaal, H, Hogan, RJ, Tripp, RA, Appaiah, U, Anand, SK, Campi, TW, Ford, MJ, Reed, JC, Lin, J, Akintunde, O, Copeland, K, Nichols, C, Petrouski, E, Moreira, AR, Jiang, IT, DeYarman, N, Brown, I, Lau, S, Segal, I, Goldsmith, D, Hong, S, Asundi, V, Briggs, EM, Phyo, NS, Froehlich, M, Onisko, B, Matlack, K, Dey, D, Lingappa, JR, Prasad, MD, Kitaygorodskyy, A, Solas, D, Boushey, H, Greenland, J, Pillai, S, Lo, MK, Montgomery, JM, Spiropoulou, CF, Korth, C, Selvarajah, S, Paulvannan, K, Lingappa, VR. A Pan-Respiratory Antiviral Chemotype Targeting a Host Multi-Protein Complex. bioRxiv. 2023; :. doi: 10.1101/2021.01.17.426875. PubMed PMID:34931190 PubMed Central PMC8687465.
  3. Lingappa, JR, Lingappa, VR, Reed, JC. Addressing Antiretroviral Drug Resistance with Host-Targeting Drugs-First Steps towards Developing a Host-Targeting HIV-1 Assembly Inhibitor. Viruses. 2021;13 (3):. doi: 10.3390/v13030451. PubMed PMID:33802145 PubMed Central PMC8001593.
  4. Reed, JC, Solas, D, Kitaygorodskyy, A, Freeman, B, Ressler, DTB, Phuong, DJ, Swain, JV, Matlack, K, Hurt, CR, Lingappa, VR, Lingappa, JR. Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly. J Virol. 2021;95 (3):. doi: 10.1128/JVI.00883-20. PubMed PMID:33148797 PubMed Central PMC7925099.
  5. Barajas, BC, Tanaka, M, Robinson, BA, Phuong, DJ, Chutiraka, K, Reed, JC, Lingappa, JR. Identifying the assembly intermediate in which Gag first associates with unspliced HIV-1 RNA suggests a novel model for HIV-1 RNA packaging. PLoS Pathog. 2018;14 (4):e1006977. doi: 10.1371/journal.ppat.1006977. PubMed PMID:29664940 PubMed Central PMC5940231.
  6. Reed, JC, Westergreen, N, Barajas, BC, Ressler, DTB, Phuong, DJ, Swain, JV, Lingappa, VR, Lingappa, JR. Formation of RNA Granule-Derived Capsid Assembly Intermediates Appears To Be Conserved between Human Immunodeficiency Virus Type 1 and the Nonprimate Lentivirus Feline Immunodeficiency Virus. J Virol. 2018;92 (9):. doi: 10.1128/JVI.01761-17. PubMed PMID:29467316 PubMed Central PMC5899207.
  7. Sette, P, O'Connor, SK, Yerramilli, VS, Dussupt, V, Nagashima, K, Chutiraka, K, Lingappa, J, Scarlata, S, Bouamr, F. HIV-1 Nucleocapsid Mimics the Membrane Adaptor Syntenin PDZ to Gain Access to ESCRTs and Promote Virus Budding. Cell Host Microbe. 2016;19 (3):336-48. doi: 10.1016/j.chom.2016.02.004. PubMed PMID:26962944 PubMed Central PMC4804359.
  8. Tanaka, M, Robinson, BA, Chutiraka, K, Geary, CD, Reed, JC, Lingappa, JR. Mutations of Conserved Residues in the Major Homology Region Arrest Assembling HIV-1 Gag as a Membrane-Targeted Intermediate Containing Genomic RNA and Cellular Proteins. J Virol. 2016;90 (4):1944-63. doi: 10.1128/JVI.02698-15. PubMed PMID:26656702 PubMed Central PMC4734008.
  9. Lingappa, JR, Reed, JC, Tanaka, M, Chutiraka, K, Robinson, BA. How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle. Virus Res. 2014;193 :89-107. doi: 10.1016/j.virusres.2014.07.001. PubMed PMID:25066606 PubMed Central PMC4351045.
  10. Robinson, BA, Reed, JC, Geary, CD, Swain, JV, Lingappa, JR. A temporospatial map that defines specific steps at which critical surfaces in the Gag MA and CA domains act during immature HIV-1 capsid assembly in cells. J Virol. 2014;88 (10):5718-41. doi: 10.1128/JVI.03609-13. PubMed PMID:24623418 PubMed Central PMC4019110.
  11. Lingappa, JR, Zigmond, RE. Limited recovery of pineal function after regeneration of preganglionic sympathetic axons: evidence for loss of ganglionic synaptic specificity. J Neurosci. 2013;33 (11):4867-74. doi: 10.1523/JNEUROSCI.3829-12.2013. PubMed PMID:23486957 PubMed Central PMC3640627.
  12. Lingappa, UF, Wu, X, Macieik, A, Yu, SF, Atuegbu, A, Corpuz, M, Francis, J, Nichols, C, Calayag, A, Shi, H, Ellison, JA, Harrell, EK, Asundi, V, Lingappa, JR, Prasad, MD, Lipkin, WI, Dey, D, Hurt, CR, Lingappa, VR, Hansen, WJ, Rupprecht, CE. Host-rabies virus protein-protein interactions as druggable antiviral targets. Proc Natl Acad Sci U S A. 2013;110 (10):E861-8. doi: 10.1073/pnas.1210198110. PubMed PMID:23404707 PubMed Central PMC3593902.
  13. Reed, JC, Molter, B, Geary, CD, McNevin, J, McElrath, J, Giri, S, Klein, KC, Lingappa, JR. HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly. J Cell Biol. 2012;198 (3):439-56. doi: 10.1083/jcb.201111012. PubMed PMID:22851315 PubMed Central PMC3413349.
  14. Klein, KC, Reed, JC, Tanaka, M, Nguyen, VT, Giri, S, Lingappa, JR. HIV Gag-leucine zipper chimeras form ABCE1-containing intermediates and RNase-resistant immature capsids similar to those formed by wild-type HIV-1 Gag. J Virol. 2011;85 (14):7419-35. doi: 10.1128/JVI.00288-11. PubMed PMID:21543480 PubMed Central PMC3126549.
  15. Okeoma, CM, Huegel, AL, Lingappa, J, Feldman, MD, Ross, SR. APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions. Cell Host Microbe. 2010;8 (6):534-43. doi: 10.1016/j.chom.2010.11.003. PubMed PMID:21147467 PubMed Central PMC3023938.
  16. Thielen, BK, McNevin, JP, McElrath, MJ, Hunt, BV, Klein, KC, Lingappa, JR. Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms. J Biol Chem. 2010;285 (36):27753-66. doi: 10.1074/jbc.M110.102822. PubMed PMID:20615867 PubMed Central PMC2934643.
  17. Lingappa, JR, Thielen, BK. Assembly of immature HIV-1 capsids using a cell-free system. Methods Mol Biol. 2009;485 :185-95. doi: 10.1007/978-1-59745-170-3_13. PubMed PMID:19020826 PubMed Central PMC2678559.
  18. Klein, KC, Reed, JC, Lingappa, JR. Intracellular destinies: degradation, targeting, assembly, and endocytosis of HIV Gag. AIDS Rev. 2007;9 (3):150-61. . PubMed PMID:17982940 .
  19. Thielen, BK, Klein, KC, Walker, LW, Rieck, M, Buckner, JH, Tomblingson, GW, Lingappa, JR. T cells contain an RNase-insensitive inhibitor of APOBEC3G deaminase activity. PLoS Pathog. 2007;3 (9):1320-34. doi: 10.1371/journal.ppat.0030135. PubMed PMID:17892323 PubMed Central PMC1993843.
  20. Dooher, JE, Schneider, BL, Reed, JC, Lingappa, JR. Host ABCE1 is at plasma membrane HIV assembly sites and its dissociation from Gag is linked to subsequent events of virus production. Traffic. 2007;8 (3):195-211. doi: 10.1111/j.1600-0854.2006.00524.x. PubMed PMID:17233757 PubMed Central PMC1865004.
  21. Lingappa, JR, Dooher, JE, Newman, MA, Kiser, PK, Klein, KC. Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly. J Biol Chem. 2006;281 (7):3773-84. doi: 10.1074/jbc.M507255200. PubMed PMID:16275648 .
  22. Lingappa, VR, Lingappa, JR. Recent insights into biological regulation from cell-free protein-synthesizing systems. Mt Sinai J Med. 2005;72 (3):141-60. . PubMed PMID:15915309 .
  23. Klein, KC, Dellos, SR, Lingappa, JR. Identification of residues in the hepatitis C virus core protein that are critical for capsid assembly in a cell-free system. J Virol. 2005;79 (11):6814-26. doi: 10.1128/JVI.79.11.6814-6826.2005. PubMed PMID:15890921 PubMed Central PMC1112097.
  24. Lingappa, JR, Newman, MA, Klein, KC, Dooher, JE. Comparing capsid assembly of primate lentiviruses and hepatitis B virus using cell-free systems. Virology. 2005;333 (1):114-23. doi: 10.1016/j.virol.2004.12.024. PubMed PMID:15708597 .
  25. Newman, EN, Holmes, RK, Craig, HM, Klein, KC, Lingappa, JR, Malim, MH, Sheehy, AM. Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity. Curr Biol. 2005;15 (2):166-70. doi: 10.1016/j.cub.2004.12.068. PubMed PMID:15668174 .
  26. Dooher, JE, Lingappa, JR. Cell-free systems for capsid assembly of primate lentiviruses from three different lineages. J Med Primatol. 2004;33 (5-6):272-80. doi: 10.1111/j.1600-0684.2004.00075.x. PubMed PMID:15525328 .
  27. Dooher, JE, Pineda, MJ, Overbaugh, J, Lingappa, JR. Characterization of virus infectivity and cell-free capsid assembly of SIVMneCL8. J Med Primatol. 2004;33 (5-6):262-71. doi: 10.1111/j.1600-0684.2004.00074.x. PubMed PMID:15525327 .
  28. Klein, KC, Polyak, SJ, Lingappa, JR. Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly. J Virol. 2004;78 (17):9257-69. doi: 10.1128/JVI.78.17.9257-9269.2004. PubMed PMID:15308720 PubMed Central PMC506955.
  29. Dooher, JE, Lingappa, JR. Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells. J Virol. 2004;78 (4):1645-56. doi: 10.1128/jvi.78.4.1645-1656.2004. PubMed PMID:14747530 PubMed Central PMC369511.
  30. Zimmerman, C, Klein, KC, Kiser, PK, Singh, AR, Firestein, BL, Riba, SC, Lingappa, JR. Identification of a host protein essential for assembly of immature HIV-1 capsids. Nature. 2002;415 (6867):88-92. doi: 10.1038/415088a. PubMed PMID:11780123 .
  31. Singh, AR, Hill, RL, Lingappa, JR. Effect of mutations in Gag on assembly of immature human immunodeficiency virus type 1 capsids in a cell-free system. Virology. 2001;279 (1):257-70. doi: 10.1006/viro.2000.0706. PubMed PMID:11145907 .
  32. Lingappa, JR, Hill, RL, Wong, ML, Hegde, RS. A multistep, ATP-dependent pathway for assembly of human immunodeficiency virus capsids in a cell-free system. J Cell Biol. 1997;136 (3):567-81. doi: 10.1083/jcb.136.3.567. PubMed PMID:9024688 PubMed Central PMC2134302.
  33. Lingappa, JR, Martin, RL, Wong, ML, Ganem, D, Welch, WJ, Lingappa, VR. A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle. J Cell Biol. 1994;125 (1):99-111. doi: 10.1083/jcb.125.1.99. PubMed PMID:7908022 PubMed Central PMC2120005.
  34. Lingappa, JR, Zigmond, RE. Pineal transplants in oculo: limitations on the ability of collateral sprouts of foreign neurons to establish normal function. J Neurosci. 1987;7 (11):3525-8. doi: 10.1523/JNEUROSCI.07-11-03525.1987. PubMed PMID:3681404 PubMed Central PMC6569029.
  35. Lingappa, JR, Zigmond, RE. A histochemical study of the adrenergic innervation of the rat pineal gland: evidence for overlap of the innervation from the two superior cervical ganglia and for sprouting following unilateral denervation. Neuroscience. 1987;21 (3):893-902. doi: 10.1016/0306-4522(87)90045-5. PubMed PMID:3627441 .
  36. Lingappa, VR, Lingappa, JR, Blobel, G. Signal sequences for early events in protein secretion and membrane assembly. Ann N Y Acad Sci. 1980;343 :356-61. doi: 10.1111/j.1749-6632.1980.tb47264.x. PubMed PMID:6994554 .
  37. Lingappa, VR, Lingappa, JR, Blobel, G. Chicken ovalbumin contains an internal signal sequence. Nature. 1979;281 (5727):117-21. doi: 10.1038/281117a0. PubMed PMID:471058 .
  38. Lingappa, VR, Lingappa, JR, Prasad, R, Ebner, KE, Blobel, G. Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein. Proc Natl Acad Sci U S A. 1978;75 (5):2338-42. doi: 10.1073/pnas.75.5.2338. PubMed PMID:276877 PubMed Central PMC392548.
  39. Polyak SJ, Klein KC, Shoji I, Miyamura T, Lingappa JR. Assemble and Interact: Pleiotropic Functions of the HCV Core Protein. In: Tan SL, editor. SourceHepatitis C Viruses: Genomes and Molecular Biology. Norfolk (UK): Horizon Bioscience; 2006. Chapter 3. PubMed PMID:21250388

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