Citation
López-Donaire, María Luisa; Sussman, Eric M.; Fernández-Gutiérrez, Mar; Méndez-Vilas, Antonio; Ratner, Buddy D.; Vázquez-Lasa, Blanca; & San Román, Julio (2012).
Amphiphilic Self-Assembled “Polymeric Drugs”: Morphology, Properties, and Biological Behavior of Nanoparticles.
Biomacromolecules, 13(3), 624-635.
Abstract
This article reports the fabrication and characterization of NPs based on the self-assembling of polymeric drugs with amphiphilic character synthetized from oleyl 2-acetamido-2-deoxy-α-d-glucopyranoside methacrylate and vinyl pyrrolidone (OAGMA-VP). NPs were spherical, with an apparent hydrodynamic diameter between 91 and 226 nm and with zeta potential values that ensure stability. Atomic concentrations of C, O, and N, determined by X-ray photoelectron spectroscopy (XPS) of NPs, compared well with the corresponding theoretical values. High resolution XPS C1s spectra suggest that the carbons bound to heteroatoms or carbonyl groups are preferentially situated on the surface of the NP samples. ToF-SIMS spectra analyzed by principal component analysis (PCA) indicated that ions coming from acetyl and oleyl groups of OAGMA play important roles in the outer structure of NPs. Water contact angle and surface tension values of NPs were characteristic of hydrophilic surfaces, confirming the location of VP sequences on the surface. Cell culture assays showed that copolymeric NPs did not compromise biocompatibility of human fibroblasts according to ISO standard, but they were cytotoxic on a human glioblastoma cell line (A-172).
Reference Type
Journal Article
Secondary Title
Biomacromolecules
Author(s)
López-Donaire, María LuisaSussman, Eric M.Fernández-Gutiérrez, MarMéndez-Vilas, AntonioRatner, Buddy D.Vázquez-Lasa, BlancaSan Román, Julio
Year Published
2012
Date Published
1331510400
Volume Number
13
Issue Number
3
Pages
624-635
ISSN/ISBN
1525-7797
DOI
Amphiphilic Self-Assembled “Polymeric Drugs”10.1021/bm300043f
