Grafting of Bioactive Polymers with Various Architectures: A Versatile Tool for Preparing Antibacterial Infection and Biocompatible Surfaces

Citation

Chouirfa, H.; Evans, M. D. M.; Bean, P.; Saleh-Mghir, A.; Cremieux, A. C.; Castner, D. G.; Falentin-Daudre, C.; & Migonney, V. (2018). Grafting of Bioactive Polymers with Various Architectures: A Versatile Tool for Preparing Antibacterial Infection and Biocompatible Surfaces. ACS Appl Mater Interfaces, 10(2), 1480-1491. PMCID: 5800312

Abstract

The aim of this Research Article is to present three different techniques of poly(sodium styrene sulfonate) (polyNaSS) covalent grafting onto titanium (Ti) surfaces and study the influence of their architecture on biological response. Two of them are "grafting from" techniques requiring an activation step either by thermal or UV irradiation. The third method is a "grafting to" technique involving an anchorage molecule onto which polyNaSS synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization is clicked. The advantage of the "grafting to" technique when compared to the "grafting from" technique is the ability to control the architecture and length of the grafted polymers on the Ti surface and their influence on the biological responses. This investigation compares the effect of the three different grafting processes on the in vitro biological responses of bacteria and osteoblasts. Overall outcomes of this investigation confirmed the significance of the sulfonate functional groups on the biological responses, regardless of the grafting method. In addition, results showed that the architecture and distribution of grafted polyNaSS on Ti surfaces alter the intensity of the bacteria response mediated by fibronectin.

Keyword(s)

Anti-Bacterial Agents
Osteoblasts
Polymers/*chemistry
Surface Properties
Titanium

Notes

Chouirfa, Hamza
Evans, Margaret D M
Bean, Penny
Saleh-Mghir, Azzam
Cremieux, Anne Claude
Castner, David G
Falentin-Daudre, Celine
Migonney, Veronique
P41 EB002027/EB/NIBIB NIH HHS/
ACS Appl Mater Interfaces. 2018 Jan 17;10(2):1480-1491. doi: 10.1021/acsami.7b14283. Epub 2018 Jan 5.

Reference Type

Journal Article

Secondary Title

ACS Appl Mater Interfaces

Author(s)

Chouirfa, H.
Evans, M. D. M.
Bean, P.
Saleh-Mghir, A.
Cremieux, A. C.
Castner, D. G.
Falentin-Daudre, C.
Migonney, V.

Year Published

2018

Date Published

1737072000

Volume Number

Issue Number

Pages

1480-1491

ISSN/ISBN

1944-8252 (Electronic)
1944-8244 (Linking)

DOI

10.1021/acsami.7b14283

PMCID

5800312