Citation
Chang, Yung; Chen, Shengfu; Zhang, Zheng; & Jiang, Shaoyi (2006).
Highly Protein-Resistant Coatings from Well-Defined Diblock Copolymers Containing Sulfobetaines.
Langmuir, 22(5), 2222-2226.
Abstract
Three well-defined diblock copolymers of poly(sulfobetaine methacrylate) [poly(SBMA)] and poly(propylene oxide) (PPO) were synthesized by the sequential addition of SBMA monomer to fixed amounts of PPO using an atom transfer radical polymerization method and varying poly(SBMA) lengths. These copolymers were characterized by 1H NMR and aqueous gel permeation chromatography. These copolymers were physically adsorbed onto a surface plasmon resonance (SPR) sensor surface covered by methyl-terminated self-assembled monolayers, followed by the in situ evaluation of protein adsorption on the adsorbed copolymers. It is found that the behavior of the protein adsorption depends on the molecular weight of the copolymers. Results show that the diblock copolymers containing poly(SBMA) can be highly protein resistant when surface SBMA densities are well controlled. Thus, copolymers containing zwitterionic groups are ideal for resisting protein adsorption when the surface density of zwitterionic groups is controlled.
Reference Type
Journal Article
Secondary Title
Langmuir
Author(s)
Chang, YungChen, ShengfuZhang, ZhengJiang, Shaoyi
Year Published
2006
Date Published
1138752000
Volume Number
22
Issue Number
5
Pages
2222-2226
DOI
10.1021/la052962v
