Chronic infection and Cystic Fibrosis Research

Our lab seeks to improve understanding of chronic bacterial infections and to devise new diagnostic and therapeutic approaches. We focus on the opportunistic pathogen Pseudomonas aeruginosa, other Gram negative organisms, and microbiome analyses to study chronic infections that afflict people with cystic fibrosis and other diseases.

We use genomic, evolutionary, and molecular biology approaches in multi-disciplinary research that involves microbiologists, genome scientists, physicians, immunologists, and clinical researchers. We are located in the School of Medicine at the University of Washington in Seattle.

 

See our research at:

• NACFC November 2023

 

Congratulations to Sardar for receiving the CFF Fellowship.

Congratulations to Sam for receiving the Charlie Moore award.

Congratulations to Sam for receiving the Whitely Fellowship.

 

Congratulations to our team on these recent publications:

Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density but lung infections generally persist

Genome Capture Sequencing Selectively Enriches Bacterial DNA and Enables Genome-Wide Measurement of Intrastrain Genetic Diversity in Human Infections

Combining Ivacaftor and Intensive Antibiotics Achieves Limited Clearance of Cystic Fibrosis Infections

A Population-level Strain Genotyping Method to Study Pathogen Strain Dynamics in Human Infections

Cystic Fibrosis Lung Function Decline after Within-Host Evolution Increases Virulence of Infecting Pseudomonas aeruginosa

We are currently recruiting postdocs with interest in genetic diversification and development of antibiotic resistance in chronic infections.