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• Overview

The REPLACE DARE (Death After Replacement Evaluation) mortality risk score is a tool designed to further assist physicians in predicting expected 6-month all-cause mortality rates for patients prior to replacing an existing cardiac implantable electrical device (CIED). Its validity in patients undergoing the initial implant of a CIED has not been established.

REPLACE DARE Mortality Risk Score Calculator

Admitted for Heart Failure in Previous 12 Months

Yes No

NYHA Classification

Class I Class II Class III Class IV

None  (for subjects without a diagnosis for Heart Failure)

Chronic Kidney Disease Stage

1 (Normal, or minimal disease with normal GFR of ≥ 90) 2 (Mild disease with decreased GFR of 69-89) 3 (Moderate disease with decreased GFR of 30-59) 4 (Severe disease with decreased GFR of 15-29) 5 (Kidney failure with GFR of < 15, or dialysis)

Class I or Class III Anti-arrhythmic Drug Use

Yes No

History of Cerebrovascular Disease

Yes No

Age

< 63 63 - 72 73 - 79 > 80

Mortality Risk Score	Observed Mortality in REPLACE (%)
0	2/198 (1.0)
1	6/484 (1.2)
2	12/446 (2.7)
3	16/291 (5.5)
4	11/128 (8.6)
5	10/72 (13.9)
6	5/34 (14.7)
7	5/9 (55.6)

Although this sub-analysis of the REPLACE registry was retrospective, the REPLACE data, including mortality, were collected prospectively. Data collection, though extensive, may have missed some confounding factors. The REPLACE DARE score was constructed using hazard ratios reflecting relative risk contributions of each variable which were combined into an additive mortality risk score equation. Internal validation was performed.