Marrs Nature Neuro | Cao TIPS | Naydenov Neuron | Kaplan PNAS
Distinct class of inhibitors that block 2-AG hydrolysis by ABHD6 through different mechanisms (Cao TIPS).
Molecular Components Involved in the Regulation of 2-AG Signaling by Neurons (Cao TIPS).
ABHD6 is expressed by post-synaptic terminals (Marrs Nature Neuro).
ABHD6 regulates the levels and activity of 2-AG in an activity dependent manner (Marrs Nature Neuro).
ABHD6 Blockade Decreases PTZ-Induced Seizure Incidence and Severity (Nadanov Neuron).
The Antiepileptic Effect of ABHD6 Inhibition Is Independent of Cannabinoid Receptors and Is Blocked by GABAA Antagonism (Nadanov Neuron).
CB1R and ABHD6 expression in mouse hippocampus shows none-overlapping pattern consistent with pre- and post-synaptic expression (Nadanov Neuron).
Acute treatment of the moues model of Dravet syndrome with low dose CBD rescues sociability deficits (Kaplan PNSA).
THC and CBD act on different molecular targets and exhibit different therapeutic benefit (Kaplan PNSA).
CBD reduces action potentials in the hippocampus, a mechanism that reduces seizures in a mouse model of Dravet Syndrome (Kaplan PNSA).
Kruse Neuropsychopharm| Davis PloSone
Adolescent brain is more susceptible to THC exposure. CB1 receptor loss in VTA of adult males that consumed THC during adolescence (Kruse Neuropsychopharm).
Voluntary oral THC consumption during adolescence alters Pavlovian-conditioned approach of adulthood (Kruse Neuropsychopharm).
CB1 receptor expression in mouse striatum (Davis PloSone).
Overlap and segregation of the Mu opioid receptor (MOR, red) and the cannabinoid receptor 1 (CB1R, green) at different levels through the striatum (Davis PloSone).
Cherry Mol Cancer Thera| Diaz Eur J. Med. | Cherry Glia
Foundational chemical scaffold of ST-compounds (Cherry Mol Cancer Thera).
Peripheral injection of ST-compounds results in micromolar concentration in mouse brain showing that this class of compounds pass the blood brain barrier (Cherry Mol Cancer Thera).
ST-compounds bind to the colchicine site on tubulin through a unique low interaction mode that destabilizes microtubules and kill cancer cells through a novel mechanism (Diaz Eur J. Med.).
Our medicinal chemistry efforts led to the development of ST-compounds by rationally modifying carbazole-based scaffold that kill that kill human glioma cell lines and patient-derived (PD) glioma cells in culture with IC50 values in the nanomolar range (Diaz Eur J. Med).
Changes in GPR124 expression differentially modulate select phases of mitosis (Cherry Glia).
ch-TOG, a microtubule polymerase that regulates plus-end assembly and mitotic progression, interact with GPR124 expressed at the plasma membrane. Microtubule plus end tips (green) colocalize with GPR124-mCherry (red) in discreet areas on the plasma membrane (Cherry Glia).
