Stetson Lab


Selected publications with particular relevance to our current work are below. For a full list, please see PubMed.

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1. Maurano M, Snyder JM, Connelly C, Henao-Mejia J, Sidrauski C, Stetson DB. Immunity. 2021 PMID: 34343497

Endomembrane targeting of human OAS1 p46 augments antiviral activity. Soveg FW, Schwerk J, Gokhale NS, Cerosaletti K, Smith JR, Pairo-Castineira E, Kell AM, Forero A, Zaver SA, Esser-Nobis K, Roby JA, Hsiang TY, Ozarkar S, Clingan JM, McAnarney ET, Stone AE, Malhotra U, Speake C, Perez J, Balu C, Allenspach EJ, Hyde JL, Menachery VD, Sarkar SN, Woodward JJ, Stetson DB, Baillie JK, Buckner JH, Gale M Jr, Savan R. Elife. 2021 PMID: 34342578

Human DNA-PK activates a STING-independent DNA sensing pathway. Burleigh K, Maltbaek JH, Cambier S, Green R, Gale M, James RC, Stetson DB. Science Immunology 2019 PMID: 31980485

Tight nuclear tethering of cGAS is essential for preventing autoreactivity Volkman HE, Cambier S, Gray EE, Stetson DB. eLife 2019 PMID: 31808743

SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response.
Crowl JT, Stetson DB. Proc Natl Acad Sci U S A. 2018 PMID: 29891701

Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling.
Brault M, Olsen TM, Martinez J, Stetson DB, Oberst A. J Immunol. 2018 PMID: 29540580

The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.
Gray EE, Winship D, Snyder JM, Child SJ, Geballe AP, Stetson DB. Immunity. 2016 PMID: 27496731

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.
Pestal K, Funk CC, Snyder JM, Price ND, Treuting PM, Stetson DB. Immunity. 2015 PMID: 26588779

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway.
Lau L, Gray EE, Brunette RL, Stetson DB. Science. 2015 PMID: 26405230

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome.
Gray EE, Treuting PM, Woodward JJ, Stetson DB. J Immunol. 2015 PMID: 26223655

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors.
Brunette RL, Young JM, Whitley DG, Brodsky IE, Malik HS, Stetson DB. J Exp Med. 2012 PMID: 23045604

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.
Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB. Immunity. 2012 PMID: 22284419