Proteins are the nano-machines that carry out the vast of majority tasks within the cell. Understanding the structure and function of proteins involved in disease and important biological processes is critical to the development of novel therapeutics and biotechnologies.

Site directed spin labeling (SDSL) electron paramagnetic resonance (EPR) techniques have proven very useful methods to study dynamic proteins in complex environments. We develop novel experimental techniques, analysis methodology and modeling software to improve the sensitivity, accuracy and utility of SDSL EPR. We also utilize SDSL EPR spectroscopy to study the structure and dynamics of biologically significant proteins.