EPR spectroscopy

Our research lab uses EPR spectroscopy in all its basic and advanced variants as our core technology. We are developing improved theory, software, and hardware to gain faster, more detailed and more robust data through increased sensitivity and resolution of measurements and increased reliability and ease of data interpretation.

Protein Structure and Dynamics

Proteins are the nano-machines that carry out the vast of majority tasks within the cell. Understanding the structure and function of proteins involved in disease and important biological processes is critical to the development of novel therapeutics and biotechnologies. Site directed spin labeling (SDSL) electron paramagnetic resonance (EPR) techniques have proven very useful methods to study dynamic proteins in complex environments. We develop novel experimental techniques, analysis methodology and modeling software to improve the sensitivity, accuracy and utility of SDSL EPR.

Metallo- and radical enzymes

Many of the most difficult and complex chemical transformations in nature make use of redox or radical chemistry. Enzymes use transition metal ions, metal ion clusters, and very reactive organic radicals in their catalytic centers to perform difficult substrate transformations. Many of these reactions are essential to life, and some of them are pathologically relevant. We study the structural and dynamic details of these reactions to understand how these reactive paramagnetic intermediates are generated, harnessed and controlled.