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SURGICAL ONCOLOGY  Case #1 - A 32 year old with a lesion on her lower...    Go to previous image Go to next image
Image #2 (#2of 14 found)
Basal cell carcinoma: Nodular type
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Basal cell carcinoma (clinical)  
Basal cell carcinoma (histology)  
Aggregate of basaloid cells  
Epidermis  
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40X magnification view  
Aggregate of basaloid cells  
Epidermis  
Cleft  
100X magnification area  
100X magnification view  
Aggregate of basaloid cells  
Cells in the periphery  
Cleft  
Detail:
Clinical: dome-shaped, pearly or flesh-colored papule or nodule with telangiectasia; center may be ulcerated. Typically occur in sun exposed areas of fair skinned individuals (also can occur in Hispanics). They are slow growing but can outgrow their blood supply leading to ulceration and bleeding. Rarely metastasize.

Pathology: Aggregates of basaloid cells often contiguous with the epidermis. Neoplastic cells are uniform in size and possess large nuclei and scant cytoplasm. Cells in the periphery of the tumor islands align in a parallel array that has been termed palisading. A characteristic cleft is often present between neoplastic cells and fibrous stroma.

S Taylor © UT Southwestern
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