Current Roles:
Sr. Research Scientist, Department of Pharmaceutics
ADMET and Modeling Leader, TLC-ART Drug Development Program
Project Lead, QPS, and PBPK initiatives
Director of SAAM II software & consulting
Simone Perazzolo, Ph.D., is a Modeling and Simulation Scientist who leads the TLC-ART program’s preclinical and clinical pharmacokinetics and modeling initiatives. His expertise includes mechanistic modeling of biological and pharmacological systems, with a focus on PBPK modeling for nanoparticles, long-acting drugs, and extended-release formulations. Simone has also developed the first whole-body PBPK lymphatic system to study particle and other large molecules (eg, vaccine) distribution in the lymphatic system. He is involved in model-informed drug development for anti-cancer drugs and SARS-CoV2 antivirals, as well as understanding parenteral routes of administration and viral clearance in special populations.
Bio
Dr. Perazzolo has more than 10 years of experience in modeling and simulation in life science. Previously, he worked at the University of Virginia (VA) in tuning the FDA-approved glucose-insulin regulation simulator in the so-called Artificial Pancreas Project under the supervision of Profs C. Cobelli and B. Kovatchev. His Ph.D. is in biomedical engineering and mathematical modeling at the University of Southampton (UK) with a thesis titled “Modelling the Nutrient Transfer across the Placenta” under the supervision of Doctor Sengers and placentologist Doctor Lewis. In 2020, Dr. Perazzolo completed his 3-year postdoctoral fellowship at the UW School of Pharmacy under the supervision of Profs Danny Shen and Rodney Ho, with a track record of PK modeling publications about novel long-acting antiretroviral formulations for targeted long-acting HIV therapy, one of which was awarded the June 2020 front page in the Journal of Pharmaceutical Sciences.
Awards, Media and Conferences
Simone was awarded Outstanding Early Career Scientist by The Editorial Staff and the American Pharmacists Association for their most original and significant scientific findings in the Journal of Pharmaceutical Sciences class of 2022.
- Simone was featured on Italian national TV in the early stages of the COVID-19 pandemic in March 2020 with more than 2 million audience shares.
- Simone and Rodney were featured in the Program Magazine handed out to participants in 2022 AAPS Boston.
- Sympisium at 2022 AAPS PharmSci360 in Boston
- Plenary talk at LEAP workshop ahead of CROI 2023 in Seattle
Education
- Postdoc Fellow in Pharmaceutics – University of Washington Dep of Pharmaceutics (WA)
- Ph.D. in Biomedical Engineering – University of Southampton (UK)
- MSc in Bioengineering – University of Padua (ITA) and University of Virginia (VA)
- BSc in Biomedical Engineering- University of Padua (ITA)
Social: Pubmed, Researchgate, LinkedIn
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