Selected Publications

• Xie X, Zhang O, Yeo MJR, Lee C, Harry SA, Paul L, Li Y, Payne NC, Nam E, Kwok HS, Jiang H, Mao H, Hadley JL, Lin H, Batts M, Gosavi PM, D'Angiolella V, Cole PA, Mazitschek R, Northcott PA, Zheng N*, Liau BB*. Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations. 2024. NATURE (in press). (*Co-corresponding). (Pre-print)
• Yeo MJ, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Bar-Peled L, Cole PA, Mazitschek R, Liau BB*, Zheng N.* UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. 2024 NATURE (in press). (*Co-corresponding). (Pre-print)
• Cao S, Garcia SF, Shi H, James EI, Kito Y, Shi H, Mao H, Kaisari S, Rona G, Deng S, Goldberg HV, Ponce J, Ueberheide B, Lignitto L, Guttman M, Pagano M*, Zheng N*. 2024. Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress. CELL. 2024 Oct 30:S0092-8674(24)01188-7. (*Co-corresponding). (Pre-print)
• Zhou G, Rusnac DV, Park H, Canzani D, Nguyen HM, Stewart L, Bush MF, Nguyen PT, Wulff H, Yarov-Yarovoy V, Zheng N*, DiMaio F*. 2024 An artificial intelligence accelerated virtual screening platform for drug discovery. NAT COMM15(1):7761. (*Co-corresponding).
• Tonggu L, Wisedchaisri G, Gamal El-Din TM, Lenaeus MJ, Logan MM, Toma T, Du Bois J, Zheng N*, Catterall WA*. 2024 Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin. NAT COMM 15(1):2306. (*Co-corresponding).
• Lenaeus M, Gamal El-Din TM, Tonggu L, Zheng N, Catterall WA. 2023 Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine.. NAT CARDIOVASC RES. 2:587-594.
• Wisedchaisri G, Gamal El-Din TM, Zheng N*, Catterall WA*. 2023. Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel NaV1.7. PNAS 120 (14) e2219624120. (*Co-corresponding).
• Cao S, Kang S, Mao H, Yao J, Gu L, Zheng N. 2022. Defining Molecular Glues with a Dual-Nanobody Cannabidiol Sensor. NAT COMM 13:815.
• Welcker M, Wang B, Rusnac DV, Hussaini Y, Swanger J, Zheng N* & Clurman BE*. 2022. Two Diphosphorylated Degrons Control c-Myc Degradation by the FBW7 Tumor Suppressor. SCIENCE ADV 8:eabl7872. (*Co-corresponding).
• Jiang D, Bahn R, Gamal El-Din TM, Tonggu L, Lenaeus MJ, Pomes R, Zheng N* & Catterall WA*. 2021. Open-state Structure and Pore Gating Mechanism of the Cardiac Sodium Channel. CELL 184:5151-5162. (*Co-corresponding).
• Wisedchaisri G, Tonggu L, Gamal El-Din TM, McCord E, Zheng N* & Catterall WA*. 2020. Structural Basis for High-Affinity Trapping of the Nav1.7 Channel in Its Resting State by Tarantula Toxin. MOL CELL 81:38-48. (*Co-corresponding).
• Wang W, Withers J, Li H, Zwack PJ, Rusnac DV, Shi H, Liu L, Yan S, Hinds TR, Guttman M, Dong X* & Zheng N*. 2020. Structural Basis of Salicylic Acid Perception by Arabidopsis NPR Proteins. NATURE 586:311-316. (*Co-corresponding).
• Wang H, Shi H, Rajan H, Canarie ER, Hong S, Simoneschi D, Pagano M, Bush MF, Stoll S, Leibold EA, & Zheng N. 2020. FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster. MOL CELL 78:31-45.
• Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N*, & Catterall WA*. 2020. Structure of the Cardiac Sodium Channel. CELL 180:122-134. (*Co-corresponding).
• Hsu PL, Shi H, Leonen C, Kang J, Chatterjee C*, & Zheng N*. 2019. Structural Basis of H2B Ubiquitination-Dependent H2K4 Methylation by COMPASS. MOL CELL 76:712-723.
• Wisedchaisri G, Tonggu L, McCord E, Gamal El-Din TM, Wang L, Zheng N*, Catterall WA*. 2019. Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel. CELL 178:993-1003. (*Co-corresponding).
• Putarjunan A, Ruble J, Srivastava A, Zhao C, Rychel AL, Hofstetter AK, Tang X, Zhu JK, Tama F, Zheng N*, Torri KU*. 2019. Bipartite Anchoring of SCREAM Enforces Stomatal Initiation by Coupling MAP Kinases to SPEECHLESS. NAT PLANT 5:742-754. (*Co-corresponding) (COVER STORY)
• Kuchay S, Wang H, Marzio A, Jain K, Homer H, Fehrenbacher N, Philips MR, Zheng N*, Pagano M*. 2019. Identification of GGTase3: a Ubiquitin Ligase-Targeting Geranylgeranyltransferase. NAT STRUCT & MOL BIOL 26:628. (*Co-corresponding).
• Lim KS, Li H, Roberts EA, Gaudiano EF, Clairmont C, Sambel LA, Ponnienselvan K, Liu JC, Yang C, Kozono D, Parmar K, Yusufzai T, Zheng N, D'Andrea AD. 2018. USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors. MOL CELL 72:925-941.
• Rusnac DV, Lin HC, Canzani D, Tien KX, Hinds TR, Tsue AF, Bush MF, Yen HS, Zheng N. 2018. Recognition of the Diglycine C-End Degron by CRL2-KLHDC2 Ubiquitin Ligase. MOL CELL 72:813-822. (COVER STORY)
• Gamal El-Din TM, Lenaeus MJ, Zheng N*, Catterall WA*. 2018. Fenestrations control resting-state block of a voltage-gated sodium channel. PNAS 115:13111-13116. (*Co-correspondence)
• Shabek N, Ticchiarelli F, Mao H, Hinds TR, Leyser O, Zheng N. 2018. Structural plasticity of D3-D14 ubiquitin ligase in strigolactone signalling. NATURE 563:652-656.
• Hsu PL, Li H, Lau HT, Leonen C, Dhall A, Ong SE, Chatterjee C, Zheng N. 2018. Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. CELL 174:1106-1116.
• Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HS. 2018. C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. MOL CELL 70:602-613.
• Jiang D, Gamal El-Din TM, Ing C, Lu P, Pomes R, Zheng N.* & Catterall WA*. 2018. Structural Basis for Gating Pore Current in Periodic Paralysis. NATURE 557:590-594. (*Co-correspondence)
• Catterall WA, Wisedchaisri G, Zheng N. 2017 . The Chemical Basis for Electrical Signaling. NAT CHEM BIOL 13:455-463.
• Zheng N & Shabek N. 2017. Ubiquitin Ligases: Structure, Function, and Regulation. ANNU REV BIOCHEM 86:129-157.
• Lenaeus MJ, Gamal El-Din TM, Ing C, Ramanadane K, Pomès R, Zheng N, Catterall WA. 2017. Structures of closed and open states of a voltage-gated sodium channel. PNAS 114:E3051-E3060.
• Tang L, El-Din TG, Swanson TM, Pryde DC, Scheuer T, Zheng N* & Catterall WA*. 2016. Structural Basis for Inhibition of a Voltage-gated Ca2+ Cannel by Ca2+ Antagonist Drugs. NATURE 537:117-121. (*Co-correspondence)
• Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D’Andrea AD, & Zheng N. 2016. Allosteric Activation of Ubiquitin-Specific Proteases by b-propeller Proteins UAF1 and WDR20. MOL CELL 63:249-60.
• Brosh R, Hrynyk I, Shen J, Waghray A, Zheng N, & Lemischka I. 2016. A Dual Molecular Analog Tuner for Dissecting Protein Function in Mammalian Cells. NAT COMM 7:11742.
• Yu C, Mao H, Novitsky EJ, Tang X, Rychnovsky SD, Zheng N* & Huang L*. 2015. Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8. NAT COMM 6:10053. (*Co-correspondence)
• Wang H, Curran EC, Hinds TR, Wang EH* & Zheng N*. 2014. Crystal Structure of A TAF1-TAF7 Complex in Human Transcription Factor IID Reveals a Promoter Binding Module. CELL RES 24:1433-44.
• Nangle SN, Rosensweig C, Koike N, Tei H, Takahashi JS*, Green CB*, Zheng N* 2014. Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex. ELIFE 3:e03674. (*Co-correspondence)

• Shabek N, Zheng N. 2014. Plant ubiquitin ligases as signaling hubs. NAT STRUCT & MOL BIOL 21,4:293-6.

• Sun J, Bankston JR, Payandeh J, Hinds TR, Zagotta WN & Zheng N. 2014. Crystal structure of the plant dual-affinity nitrate transporter NRT1.1. NATURE 507:73–77.

• Zhou F, Lin Q, Zhu L, Ren Y, Zhou K, Shabek N, Wu F, Mao H, Dong W, Gan L, Ma W, Gao H, Chen J, Yang C, Wang D, Tan J, Zhang X, Guo X, Wang J, Jiang L, Liu X, Chen W, Chu J, Yan C, Ueno K, Ito S, Asami T, Cheng Z, Wang J, Lei C, Zhai H, Wu C, Wang H*, Zheng N*, Wan J*. 2013. D14-SCFD3-dependent degradation of D53 regulates strigolactone signalling. NATURE 504:406-10. (*Co-correspondence)

• Tang L, Gamal El-Din T, Payandeh J, Martinez GQ, Heard T, Scheuer T, Zheng N*, & Catterall WA* 2013. Structural basis for Ca2+ selectivity of a voltage-gated calcium channel. NATURE (*Co-correspondence)

• Nangle S, Xing W*, Zheng N* 2013. Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. CELL RES (*Co-correspondence).

• Xing W, Busino L, Hinds TR, Marionni ST, Saifee NH, Bush MF, Pagano M, & Zheng N 2013. SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket. NATURE 496:64:68.

• Fu ZQ, Yan S, Saleh A, Wang W, Ruble J, Oka N, Mohan R, Spoel SH, Tada Y, Zheng N, & Dong X 2012. NPR3 and NPR4 are receptors for the immune signal salicyclic acid in plants. NATURE 486:228-232.

• Payandeh J, Gamal El-Din, TM, Scheuer T, Zheng N*, & Catterall WA*. 2012. Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. NATURE 486:135-9. (*Co-correspondence)

• Payandeh J, Scheuer T, Zheng N*, & Catterall WA* 2011. The crystal structure of a voltage-gated sodium channel.  NATURE 475:353-358.  (*Co-correspondence)

• Sheard LB, Tan X, Mao H, Withers J, Ben-Nissan G, Hinds TR, Kobayashi Y, Hsu F, Sharon M, Browse J, He SY, Rizo J, Howe GA, & Zheng N 2010. Jasmonate perception by inositol phosphate-potentiated COI1-JAZ co-receptor. NATURE 468:400-405.

• Zimmerman ES, Schulman BA, & Zheng N 2010. Structural assembly of cullin-RING ubiquitin ligase complexes. CURR OPIN STRUCT BIOL 20:714-721.

• Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Shen, & Shao F 2010. Glutamine Deamination and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family. SCIENCE 329:1215-1218.

• Köhler A, Zimmerman E, Schneider M, Hurt E, & Zheng N 2010. Structure basis for assembly and activation of the hetero-tetrameric SAGA histone H2B deubiquitinase module. CELL 141:606-617.

• Li T, Robert EI, van Breugel PC, Strubin M & Zheng N 2009. A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. NAT STRUCT & MOL BIOL 17:105-111.

• Sheard LB & Zheng N 2009. Plant Biology: Signal advance for abscisic acid. NATURE 462:575-576 (News & Views)

• Hayashi K, Tan X, Zheng N, Hatate T, Kimura Y, Kepinski S, & Nozaki H 2008. Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. PNAS 105:5632-7.

• Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras A, Zheng N, MacCoss MJ, Angers S, & Moon RT. 2007. Wilms Tumor Suppressor WTX Negatively Regulates Wnt/b-Catenin Signaling. SCIENCE 316:1043-1046.

• Tan X, Calderon-Villalobos LIA, Sharon M, Zheng C, Robinson CV, Estelle M, & Zheng N 2007. Mechanism of Auxin Perception by the TIR1 Ubiquitin Ligase. NATURE 446:641-645. (COVER STORY)

• Angers S, Li T, Yi X, MacCoss MJ, Moon RT, & Zheng N 2006. Molecular Architecture and Assmebly of the DDB1-Cul4A Ubiquitin Ligase Machinery. NATURE 443:590-593.

• Li T, Chen X, Garbutt KC, Zhou P, & Zheng N 2006. Structure of DDB1 in complex with a Paramyxovirus V protein: Viral Hijack of A propeller cluster in ubiquitin ligase. CELL 124:105-117.

• Chen H, Shen Y, Tang X, Yu L, Wang J, Guo L, Zhang Y, Zhang H, Feng S, Strickland E, Zheng N, & Deng XW. 2006. Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. PLANT CELL 18:1991-2004.

• Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, Maccoss MJ, & Moon RT 2006.  The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. NAT CELL BIOL 8:348-357.

• Chen X, Zhang J, Lee J, Lin PS, Ford JM, Zheng N & Zhou P 2006.  A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins. MOL CELL 22:489-499.

• Martinez SE, Bruder S, Schultz A, N. Zheng. Schultz JE, Beavo JA, & Linder JU. 2005. Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization. PNAS 102:3082-3087.

• Bruder S, Linder JU, Martinez SE,, N. Zheng. Beavo JA, & Schultz JE. 2005. The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. PNAS 102:3088-3092.

• Li T, Pavletich NP, Schulman BS, & Zheng N 2005. High-Level Expression and Purification of Recombinant SCF ubiquitin Ligases. Ed. Raymond J. Deshaies. METHOD IN ENZYMOL 398: 125-142.

• Goldenberg SJ, Cascio TC, Shumway SD, Garbutt KC, Liu J, Xiong Y, & Zheng N 2004. Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases. CELL 119: 517-528.

• Zhang J, Zheng N, & Zhou P 2003. Exploring the functional complexity of cellular proteins by protein knockout. PNAS 100:14127-14132.