Proteins are architecturally complex macromolecules, which interpret, execute, and maintain the genetic blueprint of life encoded by DNA. Their intricate interactions and coordinated functions are not only critical to all biological processes, but also to every aspect of human health and well-being. We use structural biology approach to dissect the molecular mechanisms of protein functions and biological interactions in various kingdoms of life. By probing nature in its finest atomic details, we strive to understand what makes life possible and what goes wrong in different human diseases. We aim to applying the underlying principles we learn to the development of novel therapeutics as well as the ecological balance of our planet.