GENETICS. C. ELEGANS. BIOCHEMISTRY. 

Our lab works primarily with Caenorhabditis elegans to study both neuromodulation and speciation. We are a part of the Department of Biochemistry at the University of Washington.

AILION LAB
A brief introduction...

THE AILION LAB

Our lab works on two independent projects: (1) the molecular and cellular mechanisms of neuromodulator release and G protein signaling, and (2) the molecular genetics of hybrid incompatibility. We use C. elegans and related species, as well as mammalian cell culture.

Gq Signaling

Gqα plays an important role in signaling pathways that modulate neuronal function. We want to identify new regulators and effectors of the Gq pathway. 

Dense-Core Vesicles

DCVs are responsible for the release of neuromodulators. How are DCVs formed, and how are the correct neuromodulators selected as cargo?

Speciation

Reproductive barriers between closely related organisms helps drive speciation. We want to identify the molecular mechanisms that mediate hybrid incompatibility within species.