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Books and News & Views


T. L. van Neel§, A. B. Theberge§. “Programmable capillary action controls fluid flows.” Nature, News & Views2021595, 31–32. (PDF) (§ Corresponding authors)

J. Berthier, A. B. Theberge, E. Berthier. Open-channel microfluidics: fundamentals and applications. Morgan & Claypool Publishers: San Rafael, CA, 2019.


Peer-Reviewed Publications from University of Washington

(§ denotes co-corresponding authors; * denotes equal authorship)


56. W.-c Tu*, I. Jeacopello*, A. Blom, E. Alfaro, V. A. M. Shinkawa, D. B. Hatchett, J. C. Sanchez, A. M. McManamen, X. Su, E. Berthier, S. Thongpang, E. R. Wald, G. P. DeMuri§, A. B. Theberge§. Capture of Group A Streptococcus by Open-Microfluidic CandyCollect Device in Pediatric Patients. 2024. Preprint: https://doi.org/10.1101/2023.12.14.23299923.

55. F. Y. Lim, H. Lea, A. Dostie, T. van Neel, G. Hassan, M. Takezawa, L. M. Starita, K. Adams, M. Boeckh, J. T. Schiffer, A. Waghmare§, E. Berthier§, A. B. Theberge§. homeRNA self-blood collection enables high-frequency temporal profiling of pre-symptomatic host immune kinetics to respiratory viral infection: a prospective cohort study. 2023, Preprint: https://www.medrxiv.org/content/10.1101/2023.10.12.23296835v2.

54. S. R. Nxele, B. Moetlhoa, T. Dlangalala, K. Maluleke, K. Kgarosi, A. B. Theberge, T. P. Mashamba-Thompson. Mobile-linked point-of-care diagnostics in community-based healthcare: A scoping review of user experiences. In review at PLOS ONE, 2023, Preprint: www.medrxiv.org/content/10.1101/2023.05.28.23290656v1.

53. J. C. Tokihiro*, J. Berthier*, A. M. McManamen, D. N. Phan, S. Thongpang, A. B. Theberge§. On the dynamic contact angle of capillary-driven microflows in open channels.  2023, Preprint: www.biorxiv.org/content/10.1101/2023.04.24.537941v1.

52. F. Y. Lim, S.-Y. Kim, K. N. Kulkarni, R. L. Blazevic, L. E. Kimball, H. G. Lea, A. J. Haack, M. S. Gower, T. Stevens-Ayers, L. M. Starita, M. Boeckh, O. Hyrien, J. T. Schiffer§, A. B. Theberge§, A. Waghmare§. High-frequency home self-collection of capillary blood correlates IFI27 expression kinetics to SARS-CoV-2 viral clearance. J. Clin. Investig., 2023, 133, Article e173715.

51. J. C. Tokihiro*, W.-c. Tu*, J. Berthier*, J. J. Lee, A. M. Dostie, J. W. Khor, M. Eakman, A. B. Theberge§, E. Berthier§. Enhanced capillary pumping using open-channel capillary trees with integrated paper pads. Phys. Fluids, 2023, 35, Article 082120.

50. R. M. Steinbach, F. El Baidouri, L. M. Y. Mitchison-Field, F. Y. Lim, J. Ekena, E. Vogt, A. Gladfelter, A. B. Theberge, A. S. Amend. Malassezia is widespread and has undescribed diversity in the marine environment. Fungal Ecology, 2023, 65, Article 101273.

49. N. Kaverina, R. A. Schweickart, G. C. Chan, J. C. Maggiore, D. Eng, Y. Zeng, S. R. McKinzie, H. S. Perry, A. Adilijang, C. O’Connor, B. M. Veloso Pereira, C. Loretz, A. B. Theberge, J. C. Vaughan, A. Chang, M. Bitzer, N. Hukriede, J. W. Pippin, O. Wesseley, S. J. Shankland. Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span. Aging, 2023, 15, 6658–6689.

48. W.-c. Tu*, A. M. McManamen*, X. Su, I. Jeacopello, M. G. Takezawa, D. L. Hieber, G. W. Hassan, U. N. Lee, E. V. Anana, M. P. Locknane, M. W. Stephenson, V. A. M. Shinkawa, E. R. Wald, G. P. DeMuri, K. Adams, E. Berthier, S. Thongpang§, A. B. Theberge§. At-home saliva sampling in healthy adults using CandyCollect, a lollipop-inspired device. Anal. Chem., 2023, 95, 10211–10220.

Featured in ACS Newsroom on July 10, 2023.

47. Y. Zeng*, J. W. Khor*, T. L. van Neel, W.-c. Tu, J. Berthier, S. Thongpang, E. Berthier§, A. B. Theberge§. Miniaturizing chemistry and biology using droplets in open systems. Nat. Rev. Chem., 2023, 7, 439–455.

46. R. C. Bretherton, A. J. Haack, I. Kopyeva, F. Rahman, J. D. Kern, D. Bugg, A. B. Theberge, J. Davis, C. A. DeForest. User-controlled 4D biomaterial degradation with substrate-selective sortase transpeptidases for single-cell biology. Adv. Mater., 2023, 35, Article 2209904.

45. J. W. Khor*, U. N. Lee*, J. Berthier, E. Berthier§, A. B. Theberge§. Interfacial tension driven open droplet microfluidics. Adv. Mater. Interfaces, 2023, 10, Article 2202234.

44. Y. Zeng, X. Su, M. G. Takezawa, P. S. Fichtinger, U. N. Lee, J. W. Pippin, S. J. Shankland, F. Y. Lim, L. C. Denlinger, N. N. Jarjour, S. K. Mathur, N. Sandbo, E. Berthier, S. Esnault, K. Bernau§, A. B. Theberge§. An open microfluidic coculture model of fibroblasts and eosinophils to investigate mechanisms of airway inflammation. Front. Bioeng. Biotechnol., 2022, 10, Article 993872.

43. U. N. Lee,* X. Su,*, D. L. Hieber, W-c. Tu, A. M. McManamen, M. G. Takezawa, G. W. Hassan, T. C. Chan, K. N. Adams, E. R. Wald, G. P. DeMuri, E. Berthier, A. B. Theberge§, S. Thongpang§. CandyCollect: At-home saliva sampling for capture of respiratory pathogens. Lab Chip, 2022, 22, 3555–3564.

42. A. M. Dostie*, H. G. Lea*, U. N. Lee*, T. L. van Neel, E. Berthier, A. B. Theberge§. Freestanding hydrogel lumens for modeling blood vessels and vasodilation. SLAS Technol., 2022, 27, 344–349.

41. L. G. Brown*, A. J. Haack*, D. S. Kennedy, K. N. Adams, J. E. Stolarczuk, M. G. Takezawa, E. Berthier, S. Thongpang, F.Y. Lim, D, Chaussabel§, M. Garand§, A. B. Theberge§. At-home blood collection and stabilization in high temperature climates using homeRNA. Front. Digit. Health., 2022, 4, Article 903153.

40. A. J. Haack*, F. Y. Lim*, D. S. Kennedy, J. H. Day, K. N. Adams, J. J. Lee, E. Berthier, A. B. Theberge§. homeRNA: A self-sampling kit for the collection of peripheral blood and stabilization of RNA. Anal. Chem., 2021, 93, 13196–13203.

39. U. N. Lee*, T. L. van Neel*, F. Y. Lim, J. W. Khor, J. He, R. S. Vaddi, A. Q. W. Ong, A. Tang, J. Berthier, J. S. Meschke, I. V. Novosselov§, A. B. Theberge§, E. Berthier§. Miniaturizing wet scrubbers for aerosolized droplet capture.  Anal. Chem., 2021, 93, 11433–11441.

38. T. L. van Neel*, S. B. Berry*, E. Berthier, A. B. Theberge§. Localized cell-surface sampling of a secreted factor using cell-targeting beads. Anal. Chem., 2020, 92, 13634–13640.

37. J. J. Lee*, J. Berthier*, K. E. Kearney, E. Berthier, A. B. Theberge§. Open-channel capillary trees and capillary pumping. Langmuir, 2020, 36, 12795–12803.

36. S. B. Berry, A. J. Haack, A. B. Theberge, S. Brighenti, M. Svensson. Host and pathogen communication in the respiratory tract: mechanisms and models of a complex signaling microenvironment. Front. Med., 2020, 7, Article 537.

35. S. B. Berry, M. S. Gower, X. Su, C. Seshadri, A. B. Theberge§. A modular microscale granuloma model for immune-microenvironment signaling studies in vitro. Front. Bioeng. Biotechnol., 2020, 8, Article 931.

34. T. Zhang, D. Lih, R. J. Nagao, J. Xue, E. Berthier, J. Himmelfarb, Y. Zheng§, A. B. Theberge§. Open microfluidic coculture reveals paracrine signaling from human kidney epithelial cells promotes kidney specificity of endothelial cells. Am. J. Physiol. Renal Physiol., 2020, 319, F41–F51.

33. U. N. Lee*, J. H. Day*, A. J. Haack*, R. C. Bretherton, W. Lu, C. A. DeForest§, A. B. Theberge§, E. Berthier§. Layer-by-layer fabrication of 3D hydrogel structures using open microfluidics. Lab Chip, 2020, 20, 525–536.

32. J. H. Day*, T. M. Nicholson*, X. Su, T. L. van Neel, I. Clinton, A. Kothandapani, J. Lee, M. H. Greenberg, J. K. Amory, T. J. Walsh, C. H. Muller, O. E. Franco, C. R. Jefcoate, S. E. Crawford, J. S. Jorgensen, A. B. Theberge§. Injection-molded open microfluidic well plate inserts for user-friendly coculture and microscopy. Lab Chip, 2020, 20, 107–119.

31. W. S. Song, H. G. Park, S. M. Kim, S. H. Jo, B. G. Kim, A. B. Theberge, Y. G. Kim. Chemical derivatization-based LC-MS/MS method for quantitation of gut microbial short-chain fatty acids. J. Ind. Eng. Chem., 2020, 83, 297–302.

30. J. Lee*, J. Berthier*, A. B. Theberge, E. Berthier. Capillary flow in open microgrooves: bifurcations and networks. Langmuir, 2019, 35, 10667–10675.

29. T. Zhang*, J. H. Day*, X. Su, A. G. Guadarrama, N. K. Sandbo, S. Esnault, L. C. Denlinger, E. Berthier, A. B. Theberge§. Investigating fibroblast-induced collagen gel contraction using a dynamic microscale platform. Front. Bioeng. Biotechnol., 2019, 7, Article 196.

28. S. B. Berry*, J. J. Lee*, J. Berthier, E. Berthier, A. B. Theberge§. Droplet incubation and splitting in open microfluidic channels. Anal. Methods, 2019, 11, 4528–4536.

27. S. C. Millik, A. M. Dostie, D. G. Karis, P. T. Smith, M. McKenna, N. Chan, C. D. Curtis, E. Nance, A. B. Theberge§, A. Nelson§. 3D printed coaxial nozzles for the extrusion of hydrogel tubes toward modeling vascular endothelium. Biofabrication, 2019, 11, Article 045009.

26. E. Berthier*, A. M. Dostie*, U. N. Lee, J. Berthier, A. B. Theberge§. Open microfluidic capillary systems. Anal. Chem., 2019, 91, 8739–8750.

25. U. N. Lee, J. Berthier, J. Yu, E. Berthier, A. B. Theberge§. Stable biphasic interfaces for open microfluidic platforms. Biomed. Microdevices, 2019, 21, Article 16.

24. W. S. Song, H. M. Park, J. M. Ha, S. G. Shin, H. G. Park, J. Kim, T. Zhang, D. H. Ahn, S. M. Kim, Y. H. Yang, J. H. Jeong, A. B. Theberge, B. G. Kim, J. K. Lee, Y. G. Kim. Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma. Sci. Rep., 2018, 8, Article 11088.

23. J. Lee*, J. Berthier*, K. Brakke, A. M. Dostie, A. B. Theberge, E. Berthier. Droplet behavior in open biphasic microfluidics. Langmuir, 2018, 34, 5358–5366.

22. U. N. Lee, X. Su, D. J. Guckenberger, A. M. Dostie, T. Zhang, E. Berthier, A. B. Theberge§. Fundamentals of rapid injection molding for microfluidic cell-based assays. Lab Chip, 2018, 18, 496– 504.

21. S. B. Berry*, T. Zhang*, J. H. Day, X. Su, I. Z. Wilson, E. Berthier, A. B. Theberge§. Upgrading well plates using open microfluidic patterning. Lab Chip, 2017, 17, 4253–4264.


University of Washington-UW-Madison Joint Publication


20. J. Yu*, E. Berthier*, A. Craig, T. E. de Groot, S. Sparks, P. N. Ingram, D. F. Jarrard, W. Huang, D. J. Beebe§, A. B. Theberge§. Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling. Nature Biomed. Eng., 2019, 3, 830–841.


Peer-Reviewed Publications prior to University of Washington


19.     L. J. Barkal, C. L. Procknow, Y. R. Álvarez-García, M. Niu, J. A. Jiménez-Torres, R. A. Brockman- Schneider, J. E. Gern, L. C. Denlinger, A. B. Theberge, N. P. Keller, E. Berthier, D. J. Beebe. Microbial volatile communication in human organotypic lung models. Nature Commun., 2017, 8, Article 1770.

18.     L. J. Barkal*, E. Berthier*, A. B. Theberge*, N. P. Keller, D. J. Beebe. Multikingdom microscale models. PLoS Pathogens, 2017, 13, Article e1006424.

17.   T. E. de Groot, K. S. Veserat, E. Berthier, D. J. Beebe§, A. B. Theberge§. Surface-tension driven open microfluidic platform for hanging droplet culture. Lab Chip, 2016, 16, 334–344.

16.     L. J. Barkal*, A. B. Theberge*, C. J. Guo*, J. Spraker, L. Rappert, J. Berthier, K. A. Brakke, C. C. Wang, D. J. Beebe, N. P. Keller, E. Berthier. Microbial metabolomics in open microscale platforms. Nature Commun., 2016, 7, Article 10610.

15.     A. B. Theberge*, J. Yu*, E. W. K. Young, W. A. Ricke, W. Bushman, D. J. Beebe. Microfluidic multiculture assay to analyze biomolecular signaling in angiogenesis. Anal. Chem., 2015, 87, 3239–3246.

14.   C. M. Carney, J. L. Muszynski, L. N. Strotman, S. R. Lewis, R. L. O’Connell, D. J. Beebe, A. B. Theberge§, J. S. Jorgensen§. Cellular microenvironment dictates androgen production by murine fetal Leydig cells in primary culture. Biol. Reprod., 2014, 91, Article 85.

13.     P. C. Thomas, L. N. Strotman, A. B. Theberge, E. Berthier, R. O’Connell, J. M. Loeb, S. M. Berry, D. J. Beebe. Nucleic acid sample preparation using spontaneous biphasic plug flow. Anal. Chem., 2013, 85, 8641–8646.

12.     T. M. Nicholson, K. S. Uchtmann, C. D. Valdez, A. B. Theberge, T. Miralem, W. A. Ricke. Renal capsule xenografting and subcutaneous pellet implantation for the evaluation of prostate carcinogenesis and benign prostatic hyperplasia. J. Vis. Exp., 2013, 78, Article 50574.

11.     B. P. Casavant, E. Berthier, A. B. Theberge, J. Berthier, S. I. Montanez-Sauri, L. L. Bischel, K. Brakke, C. J. Hedman, W. Bushman, N. P. Keller, D. J. Beebe. Suspended microfluidics. Proc. Natl. Acad. Sci. U.S.A., 2013, 110, 10111–10116.

10.     X. Su*, A. B. Theberge*, C. T. January, D. J. Beebe. Effect of microculture on cell metabolism and biochemistry: Do cells get stressed in microchannels?. Anal. Chem., 2013, 85, 1562–1570.

9.      S. Mellouli, L. Bousekkine, A. B. Theberge, W. T. S. Huck. Investigation of ‘on water’ conditions using a biphasic fluidic platform. Angew. Chem., Int. Ed., 2012, 51, 7981–7984.

8.      A. B. Theberge, E. Mayot, A. E. Harrak, F. Kleinschmidt, W. T. S. Huck, A. D. Griffiths. Microfluidic platform for combinatorial synthesis in picolitre droplets. Lab Chip, 2012, 12, 1320–1326.

7.      Z. Lu, J. B. Napolitano, A. Theberge, A. Ali, M. L. Hammond, E. Tan, X. Tong, S. S. Xu, M. J. Latham, L. B. Peterson, M. S. Anderson, S. S. Eveland, Q. Guo, S. A. Hyland, D. P. Milot, Y. Chen, C. P. Sparrow, S. D. Wright, P. J. Sinclair. Design of a novel class of biphenyl CETP inhibitors. Bioorg. Med. Chem. Lett., 2010, 20, 7469–7472.

6.      A. B. Theberge, F. Courtois, Y. Schaerli, M. Fischlechner, C. Abell, F. Hollfelder, W. T. S. Huck. Microdroplets in microfluidics: An evolving platform for discoveries in chemistry and biology. Angew. Chem., Int. Ed., 2010, 49, 5846–5868.

5.      A. B. Theberge*, G. Whyte*, W. T. S. Huck. Generation of picoliter droplets with defined contents and concentration gradients from the separation of chemical mixtures. Anal. Chem., 2010, 82, 3449–3453.

4.      A. B. Theberge, G. Whyte, M. Frenzel, L. M. Fidalgo, R. C. R. Wootton, W. T. S. Huck. Suzuki- Miyaura coupling reactions in aqueous microdroplets with catalytically active fluorous interfaces. Chem. Commun., 2009, 6225–6227.

3.      F. Courtois, L. F. Olguin, G. Whyte, A. B. Theberge, W. T. S. Huck, F. Hollfelder, C. Abell. Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays. Anal. Chem., 2009, 81, 3008–3016.

2.      T. E. Smith, W. H. Kuo, E. P. Balskus, V. D. Bock, J. L. Roizen, A. B. Theberge, K. A. Carroll, T. Kurihara, J. D. Wessler. Total Synthesis of (-)-hennoxazole A. J. Org. Chem., 2008, 73, 142–150.

1.      T. E. Smith, W. H. Kuo, V. D. Bock, J. L. Roizen, E. P. Balskus, A. B. Theberge. Total synthesis of (-)-hennoxazole A. Org. Lett., 2007, 9, 1153–1155.