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Books and News & Views


T. L. van Neel§, A. B. Theberge§. “Programmable capillary action controls fluid flows.” Nature, News & Views2021595, 31-32. (PDF) (§ Corresponding authors)

J. Berthier, A. B. Theberge, E. Berthier. Open-channel microfluidics: fundamentals and applications. Morgan & Claypool Publishers: San Rafael, CA, 2019. (IOP Science


Peer-Reviewed Publications from University of Washington


49. F. Y. Lim, S.-Y. Kim, K. N. Kulkarni, R. L. Blazevic, L. E. Kimball, H. G. Lea, A. J. Haack, M. S. Gower, T. Stevens-Ayers, L. M. Starita, M. Boeckh, J. T. Schiffer, O. Hyrien, A. B. Theberge§, A. Waghmare§. “Longitudinal home self-collection of capillary blood using homeRNA correlates interferon and innate viral defense pathways with SARS-CoV-2 viral clearance.” In review at Science Translational Medicine. (medRxiv preprint) (§ Corresponding authors)

48. W.-c. Tu*, A. M. McManamen*, X. Su, I. Jeacopello, M. G. Takezawa, D. L. Hieber, G. W. Hassan, U. N. Lee, E. V. Anana, M. P. Locknane, M. W. Stephenson, V. A. M. Shinkawa, E. R. Wald, G. P. DeMuri, K. Adams, E. Berthier, S. Thongpang§, and A. B. Theberge§. “At-home oral bacteria collection using a lollipop-based microfluidic device.” Posted on bioRxiv. (bioRxiv preprint) (§ Corresponding authors)

47. Y. Zeng*, J. W. Khor*, T. L. van Neel, W.-c. Tu, J. Berthier, S. Thongpang, E. Berthier§, and A. B. Theberge§. “Miniaturizing chemistry and biology using droplets in open systems.” Accepted for publication at Nature Reviews Chemistry. (§ Corresponding authors)


46. J. W. Khor*, U. N. Lee*, J. Berthier, E. Berthier§, A. B. Theberge§. “Interfacial tension driven open droplet microfluidics.” In press at Advanced Materials Interfaces. (AMI, bioRxiv) (§ Corresponding authors)


45. J. J. Lee*, J. Berthier*, A. M. Dostie, J. W. Khor, J. C. Tokihiro, W-c. Tu, §, A. B. Theberge§, E. Berthier§. “Enhanced capillary pumping using open-channel capillary trees with integrated paper pads.” In review at Physics of Fluids. (bioRxiv preprint) (§ Corresponding authors)


44. Y. Zeng, X. Su, M. G. Takezawa, P. S. Fichtinger, U. N. Lee, J. W. Pippin, S. J. Shankland, F. Y. Lim, L. C. Denlinger, N. N. Jarjour, S. K. Mathur, N. Sandbo, E. Berthier, S. Esnault, K. Bernau§, A. B. Theberge§. “An open microfluidic coculture model of fibroblasts and eosinophils to investigate mechanisms of airway inflammation.” Front. Bioeng. Biotechnol. 2022. 10:993872. PMCID: PMC9558094 (bioRxiv) (§ Corresponding author)

43. U. N. Lee*, X. Su*, D. L. Hieber, W-c. Tu, A. M. McManamen, M. G. Takezawa, G. W. Hassan, T. C. Chan, K. N. Adams, E. R. Wald, G. P. DeMuri, E. Berthier, A. B. Theberge§, S. Thongpang§. “CandyCollect: At-home saliva sampling for respiratory pathogen capture.” Lab Chip. 2022, 22, 3555-3564. (bioRxiv) (§ Corresponding authors)

42. A. M. Dostie*, H. G. Lea*, U. N. Lee*, T. L. van Neel, E. Berthier, A. B. Theberge. “Freestranding hydrogel lumens for biological assays.” SLAS Technology. 2022. In press. (bioRxiv)


41. L. G. Brown*, A. J. Haack*, D. S. Kennedy, K. N. Adams, J. E. Stolarczuk, M. G. Takezawa, E. Berthier, S. Thongpang, F. Y. Lim, D. Chaussabel§, M. Garand§, A. B. Theberge§. “At-home blood collection and stabilization in high temperature climates using homeRNA.” Front. Digit. Health. 2022, 4: 903153. PMCID: PMC9405416 (bioRxiv) (§ Corresponding authors)

40. A. J. Haack*, F. Y. Lim*, D. S. Kennedy, J. H. Day, K.N. Adams, J. J. Lee, E. Berthier, A. B. Theberge. “homeRNA: A self-sampling kit for the collection of peripheral blood and stabilization of RNA.” Anal. Chem. 202193, 13196-13203. PMCID: 9134895. (ACS, bioRxiv)


39. U. N. Lee*, T. L. van Neel*, F. Y. Lim, J. W. Khor, J. He, R. S. Vaddi, J. Berthier, I. V. Novosselov§, A. B. Theberge§, E. Berthier§. “Miniaturizing wet scrubbers for aerosolized droplet capture.” Anal. Chem. 202193, 11433-11441. PMCID: 9241448. (bioRxiv, ACS) (§ Corresponding authors)


38. T. L. van Neel*, S. B. Berry*, E. Berthier, A. B. Theberge. “Localized cell-surface sampling of a secreted factor using cell-targeting beads.” Anal. Chem., 2020. 92, 13634. PMCID: PMC8259888. (bioRxiv, ACS)


37. J. J. Lee*, J. Berthier*, K. E. Kearney, E. Berthier, A. B. Theberge. “Open-channel capillary trees and capillary pumping.” Langmuir, 202036, 12795. PMCID: PMC8259885. (ACS)


36. S. B. Berry, A. J. Haack, A. B. Theberge, S. Brighenti, M. Svensson. “Host and pathogen communication in the respiratory tract: mechanisms and models of a complex signaling microenvironment.” Front. Med., 2020. 7, Article 537. PMCID: PMC7511576. (NCBI, DOI)


35. S. B. Berry, M. S. Gower, X. Su, C. Seshadri, A. B. Theberge. “A modular microscale granuloma model for immune-microenvironment signaling studies in vitro.” Frontiers in Bioengineering and Biotechnology, 2020. 8, 931. PMCID:  PMC7461927. (bioRxiv, NCBI, DOI)


34. T. Zhang, D. Lih, R. J. Nagao, J. Xue, E. Berthier, J. Himmelfarb§, Y. Zheng§, A. B. Theberge§. “Open microfluidic coculture reveals paracrine signaling from human kidney epithelial cells promotes kidney specificity of endothelial cells.” American Journal of Physiology – Renal Physiology, 2020. 319, F41. PMCID: PMC7468832. (bioRxiv, NCBI, DOI) (§ Corresponding authors) Additional infoprotocols


33. U. N. Lee*, J. H. Day*, A. J. Haack*, R.C. Bretherton, W. Lu, C. A. DeForest§, A. B. Theberge§, E. Berthier§, “Layer-by-layer fabrication of 3D hydrogel structures using open microfluidics.” Lab Chip, 202020, 525. PMCID: PMC8018606. (bioRxiv, NCBI, Lab Chip) (§ Corresponding authors)


32. J. H. Day*, T. M. Nicholson*, X. Su, T. L. van Neel, I. Clinton, A. Kothandapani, J. Lee, M. H. Greenberg, J. K. Amory, T. J. Walsh, C. H. Muller, O. E. Franco, C. R. Jefcoate, S. E. Crawford, J. S. Jorgensen, A. B. Theberge. “Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy.” Lab Chip, 202020, 107. PMCID: PMC6917835. (bioRxiv, NCBI, Lab Chip)


31. W.-S. Song, H.-G. Park, S.-M. Kim, S.-H. Jo, B.-G. Kim, A. B. Theberge, Y.-G. Kim, “Chemical derivatization-based LC-MS/MS method for quantitation of gut microbial short-chain fatty acids.” Journal of Industrial and Engineering Chemistry, 2020. 83, 297. PMCID: Not required. (Elsevier)


30. J. J. Lee*, J. Berthier*, A. B. Theberge, E. Berthier. “Capillary flow in open microgrooves: bifurcations and networks.” Langmuir, 201935, 10667. PMCID: Not required. (ACS)


29. T. Zhang*, J. H. Day*, X. Su, A. G. Guadarrama, N. K. Sandbo, S. Esnault, L. C. Denlinger, E. Berthier, A. B. Theberge, “Investigating fibroblast-induced collagen gel contraction using a dynamic microscale platform.” Front. Bioeng. Biotechnol., 2019. 7, 196. PMCID: PMC6702460 (bioRxiv, NCBI, DOI)


28. S. B. Berry*, J. J. Lee*, J. Berthier, E. Berthier, A. B. Theberge, “Droplet incubation and splitting in open microfluidic channels.” Anal. Methods, 2019. 11, 4528. PMCID: PMC7289158. (bioRxiv, NCBI, RSC)


27. S. C. Millik, A. M. Dostie, D.G. Karis, P. T. Smith, M. McKenna, N. Chan, C. D. Curtis, E. Nance, A. B. Theberge§, A. Nelson§, “3D printed coaxial nozzles for the extrusion of hydrogel tubes toward modeling vascular endothelium.” Biofabrication2019. 11, 045009. PMCID: PMC7350911. (NCBI, IOP Science) (§ Corresponding authors)


26. E. Berthier*, A. M. Dostie*, U. N. Lee, J. Berthier, A. B. Theberge, “Open microfluidic capillary systems.” Anal. Chem., 201991, 8739. PMCID: PMC7409765. (NCBI, ACS)


25. U. N. Lee, J. Berthier, J. Yu, E. Berthier, A. B. Theberge, “Stable biphasic interfaces for open microfluidic platforms.” Biomedical Microdevices, 201921, 16. PMCID: PMC6548325. (bioRxiv, NCBI, Springer)


24. W. S. Song, H. M. Park, J. M. Ha, S. G. Shin, H. G. Park, J. Kim, T. Zhang, D. H. Ahn, S. M. Kim, Y. H. Yang, J. H. Jeong, A. B. Theberge, B. G. Kim, J. K. Lee, Y. G. Kim, “Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma.” Scientific Reports, 2018. 8, 11088. PMCID: PMC6056462 (NCBI, Scientific Reports)


23. J. J. Lee*, J. Berthier*, K. A. Brakke, A. M. Dostie, A. B. Theberge, E. Berthier, “Droplet behavior in open biphasic microfluidics.” Langmuir, 2018. 18, 5358. PMCID: Not required. (ACS)


22. U. N. Lee, X. Su, D.J. Guckenberger, A. M. Dostie, T. Zhang, E. Berthier, A. B. Theberge, “Fundamentals of rapid injection molding for microfluidic cell-based assays.” Lab Chip, 2018. 18, 496. PMCID: PMC5790604. (bioRxiv, NCBI, Lab Chip)


21. S. B. Berry*, T. Zhang*, J. H. Day, X. Su, I. Z. Wilson, E. Berthier, A. B. Theberge, “Upgrading well plates using open microfluidic patterning.” Lab Chip, 2017. 17, 4253. PMCID: Not required. (RSC)


University of Washington-UW-Madison Joint Publication



20. J. Yu*, E. Berthier*, A. Craig, T. E. de Groot, S. Sparks, P. N. Ingram, D. F. Jarrard, W. Huang, D. J. Beebe§, A. B. Theberge§, “Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling.” Nature Biomed. Eng., 2019. 3, 830. PMCID: PMC7543914. (SharedIt, Nature) (§ Corresponding authors)


Peer-Reviewed Publications prior to University of Washington


19. L. J. Barkal, C. L. Procknow, Y. R. Álvarez-García, M. Niu, J. A. Jiménez-Torres, R. A. Brockman-Schneider, J. E. Gern, L. C. Denlinger, A. B. Theberge, N. P. Keller, E. Berthier, D. J. Beebe, “Microbial volatile communication in human organotypic lung models.” Nature Communications20178, Article 1770. PMCID: PMC5701243. (NCBI)

18. L. J. Barkal*, E. Berthier*, A. B. Theberge*, N. P. Keller, D. J. Beebe, “Multikingdom microscale models.” PLoS Pathogens, 2017.  13(8), e1006424. PMCID: PMC5570211. (NCBI)

17. L. J. Barkal*, A. B. Theberge*, C. J. Guo*, J. Spraker, L. Rappert, J. Berthier, K. A. Brakke, C. C Wang, D. J. Beebe, N. P. Keller, E. Berthier, “Microbial metabolomics in open microscale platforms.” Nat. Commun. 2016. 7, 10610. PMCID: PMC4742997. (NCBI) (SW File – Agar Extractor Multisize) (SW File – Agar Extractor Double Side)

16. T. E. de Groot, K. S. Veserat, E. Berthier, D. J. Beebe§, A. B. Theberge§, “Surface-tension driven open microfluidic platform for hanging droplet culture.” Lab Chip. 2016. 16, 334. PMCID: PMC4712910. (NCBI) (§ Corresponding authors)

15. A. B. Theberge*, J. Yu*,  E. W. K. Young, W. A. Ricke, W. Bushman, D. J. Beebe, “Microfluidic multiculture assay to analyze biomolecular signaling in angiogenesis.” Anal. Chem. 2015. 87, 3239. PMCID: PMC4405103.  (NCBI) (SI File) (ImageJ Analysis Macro)

14. C. M. Carney, J. L. Muszynski, L. N. Strotman, S. R. Lewis, R. L. O’Connell, D. J. Beebe, A. B. Theberge§, J. S. Jorgensen§. “Cellular microenvironment dictates androgen production by murine fetal Leydig cells in primary culture.” Biol. Reprod. 2014. 91, Article 85. PMCID: PMC4435030. (NCBI) (§ Corresponding authors)

13. P. C. Thomas, L. N. Strotman, A. B. Theberge, E. Berthier, R. O’Connell, J. M. Loeb, S. M. Berry, D. J. Beebe, “Nucleic acid sample preparation using spontaneous biphasic plug flow.” Anal. Chem. 2013. 85, 8641. PMCID: PMC3858960. (NCBI)

12. T. M. Nicholson, K. S. Uchtmann, C. D. Valdez, A. B. Theberge, T. Miralem, W. A. Ricke, “Renal capsule xenografting and subcutaneous pellet implantation for the evaluation of prostate carcinogenesis and benign prostatic hyperplasia.” J. Vis. Exp. 2013. PMCID: PMC3856856. (DOI, NCBI)

11. B. P. Casavant*, E. Berthier*, A. B. Theberge, J. Berthier, S. I. Montanez-Sauri, L. L. Bischel, K. Brakke, C. J. Hedman, W. Bushman, N. P. Keller, D. J. Beebe, “Suspended microfluidics.” Proc. Natl. Acad. Sci. U.S.A. 2013. 110, 10111. PMCID: PMC3690848. (NCBI)

10. X. Su*, A. B. Theberge*, C. T. January, D. J. Beebe, “Effect of microculture on cell metabolism and biochemistry: Do cells get stressed in microchannels?” Anal. Chem. 2013. 85, 1562. PMCID: PMC3565071. (NCBI)

9. S. Mellouli, L. Bousekkine, A. B. Theberge, W. T. S. Huck, “Investigation of ‘on water’ conditions using a biphasic fluidic platform.” Angew. Chem. Int. Ed. 2012. 51, 7981. PMCID:  Not required. (Wiley)

8. A. B. Theberge, E. Mayot, A. E. Harrak, F. Kleinschmidt, W. T. S. Huck, A. D. Griffiths, “Microfluidic platform for combinatorial synthesis in picolitre droplets.” Lab Chip. 2012, 12, 1320. PMCID:  Not required. (Lab Chip)

7. Z. Lu, J. B. Napolitano, A. Theberge, A. Ali, M. L. Hammond, E. Tan, X. Tong, S. S. Xu, M. J. Latham, L. B. Peterson, M. S. Anderson, S. S. Eveland, Q. Guo, S. A. Hyland, D. P. Milot, Y. Chen, C. P. Sparrow, S. D. Wright,  P. J. Sinclair, “Design of a novel class of biphenyl CETP inhibitors.” Bioorg. Med. Chem. Lett. 2010, 20, 7469. PMCID:  Not required. (Science Direct)

6. A. B. Theberge, F. Courtois, Y. Schaerli, M. Fischlechner, C. Abell, F. Hollfelder, W. T. S. Huck, “Microdroplets in microfluidics: An evolving platform for discoveries in chemistry and biology.” Angew. Chem. Int. Ed. 2010, 49, 5846. PMCID:  Not required. (Wiley)

5. A. B. Theberge*, G. Whyte*, W. T. S. Huck, “Generation of picoliter droplets with defined contents and concentration gradients from the separation of chemical mixtures.” Anal. Chem. 2010, 82, 3449. PMCID:  Not required. (ACS)

4. A. B. Theberge, G. Whyte, M. Frenzel, L. M. Fidalgo, R. C. R. Wootton, W. T. S. Huck, “Suzuki-Miyaura coupling reactions in aqueous microdroplets with catalytically active fluorous interfaces.” Chem. Commun. 2009, 6225. PMCID:  Not required. (RSC)

3. F. Courtois, L. F. Olguin, G. Whyte, A. B. Theberge, W. T. S. Huck, F. Hollfelder, C. Abell, “Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays.Anal. Chem. 2009, 81, 3008. PMCID:  Not required. (ACS)

2. T. E. Smith, W. H. Kuo, E. P. Balskus, V. D. Bock, J. L. Roizen, A. B. Theberge, K. A. Carroll, T. Kurihara, J. D. Wessler, “Total Synthesis of (-)-hennoxazole A.J. Org. Chem. 2008, 73, 142. PMCID:  Not required. (ACS)

1. T. E. Smith, W. H. Kuo, V. D. Bock, J. L. Roizen, E. P. Balskus, A. B. Theberge, Total synthesis of (-)-hennoxazole A.Org. Lett. 2007, 9, 1153. PMCID:  Not required. (ACS)