Publications

2019

Dunster GP, Crowley SJ, Carskadon MA, de la Iglesia HO. (2019) What Time Should Middle and High School Students Start School? Journal of Biological Rhythms

Lee BH, Bussi IL, de la Iglesia HO, Hague C, Koh D, Hille B. (2019) Two Indoleamines Are Secreted From Rat Pineal Gland at Night and Act on Melatonin Receptors but Are Not Night Hormones. Journal of Pineal Research

Sanchez, R.E.A., Bussi, I.L., Ben-Hamo, M., Caldart, C., Catterall, W.A., & de la Iglesia, H.O. (2019) Circadian Regulation of Sleep in a Pre-Clinical Model of Dravet Syndrome: Dynamics of Sleep Stage and Siesta Re-entrainment. Sleep

Barger LK, Sullivan JP, Blackwell T, O’Brien CS, St Hilaire MA, Rahman SA, Phillips AJK, Qadri S, Wright KP, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee P, Sanderson AL, Halbower AC, Lockley SW, Landrigan CP, Stone KL, Czeisler CA; ROSTERS Study Group. (2019) Effects on Resident Work Hours, Sleep Duration and Work Experience in a Randomized Order Safety Trial Evaluating Resident-physician Schedules (ROSTERS). Sleep

Padilla, S.L., Perez, J.G., Ben-Hamo, M., Johnson, C.W., Sanchez, R.E.A., Bussi, I.L., Palmiter, R.D. & de la Iglesia, H.O. (2019) Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism. Current Biology

2018

Dunster, G.P., de la Iglesia, L., Ben-Hamo, M., Nave, C., Fleischer, J.G., Panda, S. & de la Iglesia, H.O. (2018) Sleepmore in Seattle: Later school start times are associated with more sleep and better performance in high school students. Sci Adv, 4, eaau6200.

2017

Rattenborg NC, de la Iglesia HO, Kempenaers B, Lesku JA, Meerlo P, Scriba MF. (2017) Sleep research goes wild: new methods and approaches to investigate the ecology, evolution and functions of sleep. Philos Trans R Soc Lond B Biol Sci. 372(1734)​​

Hughes, ME, Abruzzi, KC, Allada, R, Anafi, R, Arpat, AB, Asher, G, Baldi, P, de Bekker, C, Bell-Pedersen, D, Blau, J, Brown, S, Ceriani, MF, Chen, Z, Chiu, JC, Cox, J, Crowell, AM, DeBruyne, JP, Dijk, DJ, DiTacchio, L, Doyle, FJ, Duffield, GE, Dunlap, JC, Eckel-Mahan, K, Esser, KA, FitzGerald, GA, Forger, DB, Francey, LJ, Fu, YH, Gachon, F, Gatfield, D, de Goede, P, Golden, SS, Green, C, Harer, J, Harmer, S, Haspel, J, Hastings, MH, Herzel, H, Herzog, ED, Hoffmann, C, Hong, C, Hughey, JJ, Hurley, JM, de la Iglesia, HO, et al. (2017) Guidelines for Genome-Scale Analysis of Biological Rhythms. J Biol Rhythms 32, 380-393.

Hsu YA, Gile JJ, Perez JG, Morton G, Ben-Hamo M, Turner EE, de la Iglesia HO. (2017) The Dorsal Medial Habenula Minimally Impacts Circadian Regulation of Locomotor Activity and Sleep. J Biol Rhythms. 32(5):444-455​ 

Mat AM, Dunster GP, Sbragaglia V, Aguzzi J, de la Iglesia HO. (2017) Influence of temperature on daily locomotor activity in the crab Uca pugilatorPLoS One 12(4):e0175403. 

2016

Ben-Hamo M, Larson TA, Duge LS, Sikkema C, Wilkinson CW, de la Iglesia HO, González MM. (2016) Circadian Forced Desynchrony of the Master Clock Leads to Phenotypic Manifestations of DepressioneNeuro 3(6) e0237-16.2016 1–13​

Yang L, Dai DF, Yuan C, Westenbroek RE, Yu H, West N, de la Iglesia HO, Catterall WA (2016) Loss of beta-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failureProc Natl Acad Sci U S A. 

Lee ML, Katsuyama AM, Duge LS, Sriram C, Krushelnytskyy M, Kim JJ, de la Iglesia HO (2016) Fragmentation of REM and NREM sleep without total sleep loss impairs hippocampus-dependent memory consolidationSleep 39(11):2021–2031. 

de la Iglesia HO, Moreno C, Lowden A, Louzada F, Marqueze E, Levandovski R, Pilz LK, Valeggia C, Fernandez-Duque E, Golombek DA, Czeisler CA, Skene DJ, Duffy JF, Roenneberg T (2016) Ancestral sleepCurr Biol 26:R271-272. 

2015

Sbragaglia V, Lamanna F, M Mat A, Rotllant G, Joly S, Ketmaier V, de la Iglesia HO, Aguzzi J. (2015) Identification, Characterization, and Diel Pattern of Expression of Canonical Clock Genes in Nephrops norvegicus (Crustacea: Decapoda) Eyestalk. PLoS One 10(11):e0141893 

Pellman, BA, Kim, E, Reilly, M, Kashima, J, Motch, O, de la Iglesia, HO, and Kim, JJ (2015). Time-specific fear acts as a non-photic entraining stimulus of circadian rhythms in ratsScientificReports 5:14916. 

de la Iglesia HO, Fernandez-Duque E, Golombek DA, Lanza N, Duffy JF, Czeisler CA, Valeggia CR (2015) Access to Electric Light Is Associated with Shorter Sleep Duration in a Traditionally Hunter-Gatherer CommunityJBiolRhythms 30:342-350. 

Kalume F, Oakley JC, Westenbroek RE, Gile J, de la Iglesia HO, Scheuer T, Catterall WA (2015) Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome. NeurobiolDis77:141-154. 

2014

de la Iglesia HO, Lee M (2014) A time to wake, a time to sleep. In In Mechanisms of Circadian Systems in Animals and Their Clinical Relevance, R. Aguilar -Roblero, M.L. Fanjul-Moles and M. Díaz-Muñoz, eds. (New York: Springer International), p. 380.

Patton DF, Katsuyama AM, Pavlovski I, Michalik M, Patterson Z, Parfyonov M, Smit AN, Marchant EG, Chung J, Abizaid A, Storch KF, de la Iglesia HO, Mistlberger RE (2014) Circadian mechanisms of food anticipatory rhythms in rats fed once or twice daily: clock gene and endocrine correlatesPLoSOne 9:e112451. 

Hsu, YW, Wang, SD, Wang, S, Morton, G, Zariwala, HA, de la Iglesia, HO & Turner, EE (2014) Role of the dorsal medial habenula in the regulation of voluntary activity, motor function, hedonic state, and primary reinforcementJ. Neurosci. 34, 11366-11384. 

2013

Smarr BL, Gile JJ, de la Iglesia HO (2013) Oestrogen-independent circadian clock gene expression in the anteroventral periventricular nucleus in female rats: Possible role as an integrator for circadian and ovarian signals timing the LH surgeJNeuroendocrinol 25:1273–1279. 

Smarr BL, Schwartz MD, Wotus C, de la Iglesia HO (2013) Re-examining “temporal niche”IntegrCompBiol 53:165-174. 

Kronfeld-Schor N, Dominoni D, de la Iglesia HO, Levy O, Herzog ED, Dayan T, Helfrich-Forster C (2013) Chronobiology by moonlightProcRSocB280:20123088. 

Yao, J, de la Iglesia, HO & Bajjalieh, SM (2013) Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory micePloSOne 8, e68215. 

Wotus C, Lilley TR, Neal A, Suleiman N, Schmuck S, Smarr BL, de la Iglesia HO (2013) Forced desynchrony reveals independent contributions of suprachiasmatic oscillators to the daily plasma corticosterone rhythm in rats. PlosONE 8:e68793. 

de la Iglesia HO, Johnson CH (2013) Biological clocks: riding the tidesCurrBiol23:R921-923. 

2012

Han S, Tai C, Westenbroek RE, Yu FH, Cheah CS, Potter GB, Rubenstein JL, Scheuer T, de la Iglesia HO, Catterall WA (2012) Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmissionNature 489:385-390. 

Hut RA, Kronfeld-Schor N, Van der Vinne V, de la Iglesia HO (2012) In search of a temporal niche: Environmental factorsProgBrainRes199:281-304. 

Han S, Yu FH, Schwartz MD, Linton JD, Bosma MM, Hurley JB, Catterall WA, de la Iglesia HO (2012) NaV1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. ProcNatlAcadSciUSA 109: E368-E377. 

Smarr BL, Morris E, de la Iglesia HO (2012)The dorsomedial suprachiasmatic nucleus times circadian expression of kiss1 and the luteinizing hormone surgeEndocrinology 153:2839-2850. 

Lilley TR, Wotus C, Taylor D, Lee JM, de la Iglesia HO (2012) Circadian regulation of cortisol release in behaviorally split golden hamstersEndocrinology 153:732-738. 

Plano SA, Agostino PV, de la Iglesia HO, Golombek DA (2012) cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodentsPLoSONE 7:e37121. 

2011

Schwartz WJ, Tavakoli-Nezhad M, Lambert CM, Weaver DR, de la Iglesia HO (2011) Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays. ProcNatlAcadSciUSA 108:17219-17224. 

Beckwith EJ, Lelito KR, Hsu YW, Medina BM, Shafer O, Ceriani MF, de la Iglesia HO (2011) Functional conservation of clock output signaling between flies and intertidal crabs. JBiolRhythms 26:518-529. 

2010

de la Iglesia HO and Hsu YW (2010) Biological clocks and rhythms in intertidal crustaceans. FrontBiosci (EliteEd) 2:1394-1404. 

Chiesa JJ, Aguzzi J, Garcia JA, Sarda F, de la Iglesia HO (2010) Light intensity determines temporal niche switching of behavioral activity in deep-water Nephropsnorvegicus (Crustacea: Decapoda). JBiolRhythms25:277-287. 

Schwartz MD, Congdon S, de la Iglesia HO (2010) Phase misalignment between suprachiasmatic neuronal oscillators impairs photic behavioral phase shifts but not photic induction of gene expression. JNeurosci30:13150-13156. 

Lopez-Olmeda JF, Tartaglione EV, de la Iglesia HO, Sanchez-Vazquez FJ (2010) Feeding entrainment of food-anticipatory activity and per1 expression in the brain and liver of zebrafish under different lighting and feeding conditions. ChronobiolInt 27:1380-1400. 

Fernandez-Duque E, de la Iglesia HO, Erkert HG (2010)Moonstruck primates: Owl monkeys (Aotus) need moonlight for nocturnal activity in their natural environment. PLoSONE 5:e12572. 

2009

Robertson JL, Clifton DK, de la Iglesia HO, Steiner RA, Kauffman AS (2009) Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surgeEndocrinology 150:3664-3671. 

Lee ML, Swanson BE, de la Iglesia HO (2009) Circadian timing of REM sleep is coupled to an oscillator within the dorsomedial suprachiasmatic nucleus. CurrBiol19:848-852. 

Schwartz MD, Wotus C, Liu T, Friesen WO, Borjigin J, Oda GA, de la Iglesia HO (2009) Dissociation of circadian and light inhibition of melatonin release through forced desynchronization in the ratProcNatlAcadSciUSA106:17540-17545. 

2008

Hsu YW, Weller JR, Christie AE, de la Iglesia HO (2008) Molecular cloning of four cDNAs encoding prepro-crustacean hyperglycemic hormone (CHH) from the eyestalk of the red rock crab Cancer productus: Identification of two genetically encoded CHH isoforms and two putative post-translationally derived CHH variants. GenCompEndocrinol 155:517-525. 

Hsu YW, Stemmler EA, Messinger DI, Dickinson PS, Christie AE, de la Iglesia HO (2008) Cloning and differential expression of two beta-pigment-dispersing hormone (beta-PDH) isoforms in the crab Cancer productus: evidence for authentic beta-PDH as a local neurotransmitter and beta-PDH II as a humoral factor. JCompNeurol 508:197-211. 

Gerashchenko D, Wisor JP, Burns D, Reh RK, Shiromani PJ, Sakurai T, de la Iglesia HO, Kilduff TS (2008) Identification of a population of sleep-active cerebral cortex neurons. ProcNatlAcadSciUSA105:10227-10232. 

de la Iglesia HO, Cambras T, Diez-Noguera A (2008) Circadian internal desynchronization: Lessons from a rat. SleepBiolRhythms 6:76-83. 

Kilduff TS, Lein ES, de la Iglesia HO, Sakurai T, Fu YH and Shaw P (2008) New developments in sleep research: molecular genetics, gene expression, and systems neurobiology. JNeurosci 28:11814-11818. 

2007

Stemmler EA, Hsu YW, Cashman CR, Messinger DI, de la Iglesia HO, Dickinson PS, Christie AE (2007) Direct tissue MALDI-FTMS profiling of individual Cancer productus sinus glands reveals that one of three distinct combinations of crustacean hyperglycemic hormone precursor-related peptide (CPRP) isoforms are present in individual crabs. GenCompEndocrinol154:184-192. 

de la Iglesia HO (2007) In situ hybridization of suprachiasmatic nucleus slices. In MethodsMolBiol, E Rosato, ed, pp 513-531, Humana Press. 

Cambras T, Weller JR, Angles-Pujoras M, Lee ML, Christopher A, Diez-Noguera A, Krueger JM, de la Iglesia HO (2007) Circadian desynchronization of core body temperature and sleep stages in the rat. ProcNatlAcadSciUSA104:7634-7639. 

2006

Hsu YW, Messinger DI, Chung JS, Webster SG, de la Iglesia HO, Christie AE (2006) Members of the crustacean hyperglycemic hormone (CHH) peptide family are differentially distributed both between and within the neuroendocrine organs of Cancer crabs: implications for differential release and pleiotropic function. JExpBiol209:3241-3256. 

Christie AE, Stemmler EA, Peguero B, Messinger DI, Provencher HL, Scheerlinck P, Hsu YW, Guiney ME, de la Iglesia HO, Dickinson PS (2006) Identification, physiological actions, and distribution of VYRKPPFNGSIFamide (Val1)-SIFamide) in the stomatogastric nervous system of the American lobster Homarus americanus. JCompNeurol496:406-421. 

de la Iglesia HO and Schwartz WJ (2006) Timely ovulation: Circadian regulation of the female hypothalamo-pituitary-gonadal axis. Endocrinology 147:1148-1153. 

2005

Fu Q, Kutz KK, Schmidt JJ, Hsu YW, Messinger DI, Cain SD, de la Iglesia HO, Christie AE, Li L (2005) Hormone complement of the Cancer productus sinus gland and pericardial organ: An anatomical and mass spectrometric investigation. JCompNeurol 493:607-626. 

2004

de la Iglesia HO, Meyer J, Schwartz WJ (2004) Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus. BrainResMolBrainRes 127:121-127. 

de la Iglesia HO, Cambras T, Schwartz WJ, Diez-Noguera A (2004) Forced desynchronization of dual circadian oscillators within the rat suprachiasmatic nucleus. CurrBiol 14:796-800. 

2003

de la Iglesia HO, Meyer J, Schwartz WJ (2003) Lateralization of circadian pacemaker output: Activation of left- and right-sided luteinizing hormone-releasing hormone neurons involves a neural rather than a humoral pathway. JNeurosci 23:7412-7414. 

Edelstein K, de la Iglesia HO, Mrosovsky N (2003) Period gene expression in the suprachiasmatic nucleus of behaviorally decoupled hamsters. BrainResMolBrainRes 114:40-45. 

Edelstein K, de la Iglesia HO, Schwartz WJ, Mrosovsky N (2003) Behavioral arousal blocks light-induced phase advances in locomotor rhythmicity but not light-induced Per1 and Fos expression in the hamster suprachiasmatic nucleus. Neuroscience118:253-261. 

2002

de la Iglesia HO, Schwartz WJ (2002) A subpopulation of efferent neurons in the mouse suprachiasmatic nucleus is also light responsive. Neuroreport 13:857-860. 

1994-2001

Zlomanczuk P, Mrugala M, de la Iglesia HO, Ourednik V, Quesenberry PJ, Snyder EY, Schwartz WJ (2002) Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus. ExpNeurol 174:162-168. 

Mitome M, Low HP, de la Iglesia HO, Schwartz WJ (2001) Constructing suprachiasmatic nucleus chimeras in vivo. BiolRhythmRes 32:221-232. 

Schwartz WJ, Carpino A, Jr., de la Iglesia HO, Baler R, Klein DC, Nakabeppu Y, Aronin N (2000) Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus. Neuroscience98:535-547. 

Jagota A, de la Iglesia HO, Schwartz WJ (2000) Morning and evening circadian oscillations in the suprachiasmatic nucleus in vitro. Nat Neurosci 3:372-376. 

de la Iglesia HO, Meyer J, Carpino A, Jr., Schwartz WJ (2000) Antiphase oscillation of the left and right suprachiasmatic nuclei. Science 290:799-801. 

de la Iglesia HO, Blaustein JD, Bittman EL (1999) Oestrogen receptor-alpha-immunoreactive neurones project to the suprachiasmatic nucleus of the female Syrian hamster. JNeuroendocrinol 11:481-490. 

Pereyra P, De la Iglesia HO, Maldonado H (1996) Training-to-testing intervals different from 24 h impair habituation in the crab Chasmagnathus. PhysiolBehav 59:19-25. 

de la Iglesia HO, Blaustein JD, Bittman EL (1995) The suprachiasmatic area in the female hamster projects to neurons containing estrogen receptors and GnRH. Neuroreport 6:1715-1722. 

de la Iglesia HO, Rodriguez EM, Dezi RE (1994) Burrow plugging in the crab Uca uruguayensis and Its synchronization with photoperiod and tides. PhysiolBehav55:913-919.

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