Cervical cancer is caused by a virus called human papillomavirus (HPV). Despite the availability of HPV 16/18 vaccines, cervical cancer screening will need to continue as current vaccines do not protect against all HPV types, nor do they protect women already infected with HPVs against development of cervical cancer.
We are doing this study to compare whether HPV testing (self-collected at home) is as effective as the currently recommended approach (Pap testing) for screening for cervical cancer. We want to know if self-collected at home HPV testing is effective, cost-effective, and/or acceptable to patients.
Patients in this study will get either self-collected at home HPV testing or regular Pap test screenings. In the home HPV test group, if your HPV test is positive you will receive a Pap test . In the standard care group, if your Pap test is abnormal you will receive an HPV test.. Any cervical cancer screening follow-up examinations will be per currently recommended guidelines.
Why do we need a new test for cervical cancer?
Pap tests are not always accurate. They can miss abnormal cells. Sometimes they can show abnormalities that are not related to cervical cancer.
What is the new experimental test?
In this study, we will compare use of a home HPV test to traditional Pap testing.
Who can enroll in the study?
Any healthy non-pregnant woman 21 years or older who has not had treatment for cervical cancer in the last two years.
What will I be asked to do if I enroll?
You will receive either a home HPV test kit or routine screening with a Pap test. In the home HPV test group, if your HPV test is positive you will receive a Pap test. We are interested in how women feel about performing a test at home compared to a having a Pap test in the office so you will be asked to complete a survey.