Molecular and Genetics Core of the
Diabetes and Endocrinology Research Center
(DERC)








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Publications with contributions by the Molecular and Genetics Core, Diabetes and Endocrinology Research Center, since 2001

1. Berfield AK, Hansen KM, Abrass CK. Rat glomerular mesangial cells require laminin-9 to migrate in response to insulin-like growth factor binding protein-5. (In Preparation)

2. Cude K, Choi H, Hsuan S, Zhang H, Wang C, Xia Z. Activation Of The ERK5-NFkB Pathway Is Required For G2/M Progression In The Cell Cycle. (In Preparation)

3. Erdélyi I, Braun KR, Van Yserloo B, Rutledge EA, Van Dijk JE, Hellmen E, Wight TN, Nederbragt H. Splice variants and catabolic products of versican in mammary tumors and mammary cell lines of the dog. (In Preparation)

4. Rutledge EA, Van Yserloo B, Moralejo DH, Ettinger RA, Fuller JM, Gaur P, Hoehna JL, Peterson MR, Jensen R, Kwitek A, Lernmark A. Coordinate Expression of Multiple Gimap Genes in the Lymphopenic BB Rat. (Submitted)

5. Raju R, Foote J, Banga JP, Hall TR, Padoa CJ, Dalakas MC, Ortqvist E, Hampe CS. Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients. J Immunol. 2005 Dec 1;175(11):7755-62.

6. Bekris LM, Shephard C, Peterson M, Hoehna J, Van Yserloo B, Rutledge E, Farin F, Kavanagh TJ, Lernmark A. Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset. Autoimmunity. 2005 Dec;38(8):567-75.

7. Chessler SD, Sweet IR, Van Yserloo B, Rutledge EA, Hall TR, Waldrop M, Suckow AT. Identification and characterization of a novel isoform of the vesicular GABA transporter with glucose-regulated expression in rat islets. In press Mol Endocrinol.

8. Berfield AK, Chait A, Oram JF, Zager RA, Johnson AC, Abrass CK. IGF-1 induces rat glomerular mesangial cells accumulate triglyceride. Am J Physiol Renal Physiol. 2005 Aug 2.

9. Hampe CS, Wallen AR, Schlosser M, Ziegler M, Sweet IR. Quantitative evaluation of a monoclonal antibody and its fragment as potential markers for pancreatic beta cell mass. Exp Clin Endocrinol Diabetes 2005 113: 381-7.

10. Hawkins T, Fuller J, Olson K, Speros S, Lernmark A. DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats. J Autoimmun. 2005 Oct 20.

11. Hoffman LR, D'Argenio DA, MacCoss MJ, Zhang Z, Jones RA, Miller SI. Aminoglycoside antibiotics induce bacterial biofilm formation. Nature. 2005 Aug 25;436(7054):1171-5.

12. Padoa CJ, Crowther NJ, Thomas JW, Lernmark A, Ortqvist E, Palmer JP, Luo D, Hampe CS. Epitope mapping of Insulin Autoantibodies using recombinant Fab. Clin Exp Immunology 2005 140: 564-571.

13. Sommandas V, Rutledge EA, Van Yserloo B, Fuller J, Lernmark A, Drexhage HA. Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat. J Autoimmun. 2005 Aug;25(1):1-12.

14. Sommandas V, Rutledge EA, Van Yserloo B, Fuller J, Lernmark A, Drexhage HA. Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background. J Autoimmun. 2005 Aug;25(1):46-56.

15. Wisse BE, Ogimoto K, Schwartz MW. Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins. Peptides. 2005 Nov 3.

16. Lamharzi N, Renard CB, Kramer F, Pennathur S, Heinecke JW, Chait A, Bornfeldt KE. Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL. Diabetes. 2004 Dec;53(12):3217-25.

17. Luo D, Gilliam LK, Greenbaum C, Bekris L, Hampe CS, Daniels T, Richter W, Marcovina SM, Rolandsson O, Landin-Olsson M, Kockum I, Lernmark A. Conformation-dependent GAD65 autoantibodies in diabetes. Diabetologia. 2004 47:1581-91.

18. Luo D., Rogers CN, Steed JT, Hampe CS, Lernmark A. Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein. J. Biotechnol. 2004 111: 97-104.

19. Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. Physiol Genomics. 2004 Oct 4;19(2):228-32. Epub 2004 Aug 24.

20. Renard CB, Kramer F, Johansson F, Lamharzi N, Tannock LR, von Herrath MG, Chait A, Bornfeldt KE. Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J Clin Invest. 2004 Sep;114(5):659-68.

21. Wisse BE, Ogimoto K, Morton GJ, Wilkinson CW, Frayo RS, Cummings DE, Schwartz MW. Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1107-13. Epub 2004 Aug 10.

22. Luo D, Rogers CN, Hampe CS, Lernmark Ĺ. Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay. J Biotechnol. 2003 103:249-55.

23. Niklasson B, Heller KE, Schonecker B, Bildsoe M, Daniels T, Hampe CS, Widlund P, Simonson WT, Schaefer JB, Rutledge E, Bekris L, Lindberg AM, Johansson S, Ortqvist E, Persson B, Lernmark A. Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus. Int J Exp Diabesity Res. 2003 Jan-Mar;4(1):35-44.

24. Padoa CJ, Banga JP, Madec AM, Ziegler M, Schlosser M, Oertqvist E, Kockum I, Palmer J, Rolandsson O, Foote J, Hampe CS. Recombinant Fab of human mAbs specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Ab. Diabetes 2003 52:2689-95.

25. Rolandsson O, Hagg E, Janer M, Rutledge E, Gaur LK, Nilsson M, Hallmans G, Lernmark A. High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INS VNTR. J Intern Med. 2003 Apr;253(4):447-53.

26. MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lernmark A. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 2002 Jul;12(7):1029-39.

27. Harmon JS, Gleason CE, Tanaka Y, Poitout V, Robertson RP. Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats. Diabetes. 2001 Nov;50(11):2481-6.


 







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