Yeast Publications: 2016-2010 | 2009-2000 | 1999-1990 | 1989-1980 | 1979-1975

2016-2010

Braun, K. A., K. M. Dombek, and E. T. Young. 2016. Snf1-dependent transcription confers glucose-induced decay upon the mRNA product. Mol. Cell. Biol. 36:628-644. [PubMed]

Parua, P. K., K. M. Dombek, and E. T. Young. 2014. Yeast 14-3-3 protein functions as a comodulator of transcription by inhibiting coactivator functions. J. Biol. Chem. 289:35542-35560. [PubMed]

Braun, K. A., and E. T. Young. 2014. Coupling mRNA synthesis and decay. Mol. Cell. Biol. 34:4078-4087. [PubMed]

Braun, K. A., S. Vaga, K.M. Dombek, F. Fang, S. Palmisano, R. Aebersold and E.T. Young. 2014. Phosphoproteomic analysis identifies proteins involved in transcription-coupled mRNA decay as targets of Snf1 signaling. Sci. Signal. 7:ra64. [PubMed] [Supplementary Files]

Parua, P. K. and E. T. Young. 2014. Binding and transcriptional regulation by 14-3-3 (Bmh) proteins requires residues outside of the canonical motif. Eukaryot. Cell 13:21-30. [PubMed] [Supplementary File]

Braun, K. A., P. K. Parua, K.M. Dombek, G.E. Miner and E.T. Young. 2013. 14-3-3 (Bmh) proteins regulate combinatorial transcription following RNA polymerase II recruitment by binding at Adr1-dependent promoters in Saccharomyces cerevisiae. Mol. Cell. Biol. 33:712-724. [PubMed] [Supplementary File]

Young, E. T., C. Zhang, K. M. Shokat, P. K. Parua, and K. A. Braun. 2012. The AMP-activated Protein Kinase Snf1 Regulates Transcription Factor Binding, RNA Polymerase II Activity, and mRNA Stability of Glucose-repressed Genes in Saccharomyces cerevisiae. J. Biol. Chem. 287:29021-29034. [PubMed] [Supplementary File]

Parua, P. K., P. M. Ryan, K. Trang, and E. T. Young. 2012. Pichia pastoris 14-3-3 regulates transcriptional activity of the methanol inducible transcription factor Mxr1 by direct interaction. Mol. Microbiol. 85:282-298. [PubMed] [Supplementary File]

Abate, G., E. Bastonini, K. A. Braun, L. Verdone, E. T. Young, and M. Caserta. 2012. Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter. Biochim. Biophys. Acta. [PubMed] [Supplementary File]

Infante, J. J., G. L. Law, and E. T. Young. 2012. Analysis of nucleosome positioning using a nucleosome-scanning assay. Methods Mol. Biol. 833:63-87. [PubMed]

Hahn, S., and E. T. Young. 2011. Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators. Genetics 189:705-36. [PubMed]

Humston, E. M., K. M. Dombek, B. P. Tu, E. T. Young, and R. E. Synovec. 2011. Toward a global analysis of metabolites in regulatory mutants of yeast. Anal. Bioanal. Chem. [PubMed] [Supplementary File]

Infante, J. J., G. L. Law, I. T. Wang, H. W. Chang, and E. T. Young. 2011. Activator-independent transcription of Snf1-dependent genes in mutants lacking histone tails. Mol. Microbiol. 80:407-22. [PubMed] [Supplementary File]

Parua, P. K., S. Ratnakumar, K. A. Braun, K. M. Dombek, E. Arms, P. M. Ryan, and E. T. Young. 14-3-3 (Bmh) proteins inhibit transcription activation by Adr1 through direct binding to its regulatory domain. Mol. Cell. Biol. 30:5273-83. [PubMed] [Supplementary Files]

Ratnakumar, S., and E. T. Young. 2010. Snf1 dependence of peroxisomal gene expression is mediated by Adr1. J. Biol. Chem. 285:10703-14. [PubMed] [Supplementary File]

2009 - 2000

Young, E. T., K. Yen, K. M. Dombek, G. L. Law, E. Chang, and E. Arms. 2009. Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant of Saccharomyces cerevisiae. Mol. Microbiol. 74:364-83. [PubMed] [Supplementary File]

Ratnakumar, S., N. Kacherovsky, E. Arms, and E. T. Young. 2009. Snf1 controls the activity of Adr1 through dephosphorylation of Ser230. Genetics 182:735-45. [PubMed] [Supplementary File]

Biddick, R., and E. T. Young. 2009. The disorderly study of ordered recruitment. Yeast 26:205-20. [PubMed]

Young, E. T., C. Tachibana, H. W. Chang, K. M. Dombek, E. M. Arms, and R. Biddick. 2008. Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression. Mol. Cell. Biol. 28:2509-16. [PubMed]

Mohler, R. E., B. P. Tu, K. M. Dombek, J. C. Hoggard, E. T. Young, and R. E. Synovec. 2008. Identification and evaluation of cycling yeast metabolites in two-dimensional comprehensive gas chromatography-time-of-flight-mass spectrometry data. J. Chromatogr. A 1186:401-11. [PubMed]

Kacherovsky, N., C. Tachibana, E. Amos, D. Fox, 3rd, and E. T. Young. 2008. Promoter binding by the Adr1 transcriptional activator may be regulated by phosphorylation in the DNA-binding region. PLoS One 3:e3213. [PubMed]

Humston, E. M., K. M. Dombek, J. C. Hoggard, E. T. Young, and R. E. Synovec. 2008. Time-dependent profiling of metabolites from Snf1 mutant and wild type yeast cells. Anal. Chem. 80:8002-11. [PubMed]

Biddick, R. K., G. L. Law, and E. T. Young. 2008. Adr1 and Cat8 mediate coactivator recruitment and chromatin remodeling at glucose-regulated genes. PLoS One 3:e1436. [PubMed]

Biddick, R. K., G. L. Law, K. K. Chin, and E. T. Young. 2008. The transcriptional coactivators SAGA, SWI/SNF, and mediator make distinct contributions to activation of glucose-repressed genes. J. Biol. Chem. 283:33101-9. [PubMed]

Tu, B. P., R. E. Mohler, J. C. Liu, K. M. Dombek, E. T. Young, R. E. Synovec, and S. L. McKnight. 2007. Cyclic changes in metabolic state during the life of a yeast cell. Proc. Natl. Acad. Sci. U.S.A. 104:16886-91. [PubMed]

Tachibana, C., R. Biddick, G. L. Law, and E. T. Young. 2007. A poised initiation complex is activated by SNF1. J. Biol. Chem. 282:37308-15. [PubMed]

Mohler, R. E., K. M. Dombek, J. C. Hoggard, K. M. Pierce, E. T. Young, and R. E. Synovec. 2007. Comprehensive analysis of yeast metabolite GC x GC-TOFMS data: combining discovery-mode and deconvolution chemometric software. Analyst 132:756-67. [PubMed]

Voronkova, V., N. Kacherovsky, C. Tachibana, D. Yu, and E. T. Young. 2006. Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae. Genetics 172:2123-38. [PubMed]

Mohler, R. E., K. M. Dombek, J. C. Hoggard, E. T. Young, and R. E. Synovec. 2006. Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry analysis of metabolites in fermenting and respiring yeast cells. Anal. Chem. 78:2700-9. [PubMed]

Tachibana, C., J. Y. Yoo, J. B. Tagne, N. Kacherovsky, T. I. Lee, and E. T. Young. 2005. Combined global localization analysis and transcriptome data identify genes that are directly coregulated by Adr1 and Cat8. Mol. Cell. Biol. 25:2138-46. [PubMed] [Supplementary Files]

Biddick, R., and E. T. Young. 2005. Yeast mediator and its role in transcriptional regulation. C. R. Biol. 328:773-82. [PubMed]

Dombek, K. M., N. Kacherovsky, and E. T. Young. 2004. The Reg1-interacting proteins, Bmh1, Bmh2, Ssb1, and Ssb2, have roles in maintaining glucose repression in Saccharomyces cerevisiae. J. Biol. Chem. 279:39165-74. [PubMed]

Young, E. T., K. M. Dombek, C. Tachibana, and T. Ideker. 2003. Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J. Biol. Chem. 278:26146-58. [PubMed] [Supplementary Files]

Infante, J. J., K. M. Dombek, L. Rebordinos, J. M. Cantoral, and E. T. Young. 2003. Genome-wide amplifications caused by chromosomal rearrangements play a major role in the adaptive evolution of natural yeast. Genetics 165:1745-59. [PubMed]

Young, E. T., N. Kacherovsky, and K. Van Riper. 2002. Snf1 protein kinase regulates Adr1 binding to chromatin but not transcription activation. J. Biol. Chem. 277:38095-103. [PubMed]

Verdone, L., J. Wu, K. van Riper, N. Kacherovsky, M. Vogelauer, E. T. Young, M. Grunstein, E. Di Mauro, and M. Caserta. 2002. Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditions. EMBO J. 21:1101-11. [PubMed]

Young, E. T., J. S. Sloan, and K. Van Riper. 2000. Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae. Genetics 154:1053-68. [PubMed]

Young, E. T., J. Sloan, B. Miller, N. Li, K. van Riper, and K. M. Dombek. 2000. Evolution of a glucose-regulated ADH gene in the genus Saccharomyces. Gene 245:299-309. [PubMed]

Young, E. T., N. Kacherovsky, and C. Cheng. 2000. An accessory DNA binding motif in the zinc finger protein Adr1 assists stable binding to DNA and can be replaced by a third finger. Biochemistry 39:567-74. [PubMed]

1999 - 1990

Sloan, J. S., K. M. Dombek, and E. T. Young. 1999. Post-translational regulation of Adr1 activity is mediated by its DNA binding domain. J. Biol. Chem. 274:37575-82. [PubMed]

Dombek, K. M., V. Voronkova, A. Raney, and E. T. Young. 1999. Functional analysis of the yeast Glc7-binding protein Reg1 identifies a protein phosphatase type 1-binding motif as essential for repression of ADH2 expression. Mol. Cell. Biol. 19:6029-40. [PubMed]

Young, E. T., J. Saario, N. Kacherovsky, A. Chao, J. S. Sloan, and K. M. Dombek. 1998. Characterization of a p53-related activation domain in Adr1p that is sufficient for ADR1-dependent gene expression. J. Biol. Chem. 273:32080-7. [PubMed]

Keller, A. D., and E. T. Young. 1997. Meiotic inheritance of functional Gal80S gene product in Saccharomyces cerevisiae. Yeast 13:441-7. [PubMed]

Dombek, K. M., and E. T. Young. 1997. Cyclic AMP-dependent protein kinase inhibits ADH2 expression in part by decreasing expression of the transcription factor gene ADR1. Mol. Cell. Biol. 17:1450-8. [PubMed]

Donoviel, M. S., and E. T. Young. 1996. Isolation and identification of genes activating UAS2-dependent ADH2 expression in Saccharomyces cerevisiae. Genetics 143:1137-48. [PubMed]

Donoviel, M. S., N. Kacherovsky, and E. T. Young. 1995. Synergistic activation of ADH2 expression is sensitive to upstream activation sequence 2 (UAS2) orientation, copy number and UAS1-UAS2 helical phasing. Mol. Cell. Biol. 15:3442-9. [PubMed]

Cheng, C., and E. T. Young. 1995. A single amino acid substitution in zinc finger 2 of Adr1p changes its binding specificity at two positions in UAS1. J. Mol. Biol. 251:1-8. [PubMed]

Cheng, C., N. Kacherovsky, K. M. Dombek, S. Camier, S. K. Thukral, E. Rhim, and E. T. Young. 1994. Identification of potential target genes for Adr1p through characterization of essential nucleotides in UAS1. Mol. Cell. Biol. 14:3842-52. [PubMed]

Dombek, K. M., S. Camier, and E. T. Young. 1993. ADH2 expression is repressed by REG1 independently of mutations that alter the phosphorylation of the yeast transcription factor ADR1. Mol. Cell. Biol. 13:4391-9. [PubMed]

Thukral, S. K., M. L. Morrison, and E. T. Young. 1992. Mutations in the zinc fingers of ADR1 that change the specificity of DNA binding and transactivation. Mol. Cell. Biol. 12:2784-92. [PubMed]

Karnitz, L., M. Morrison, and E. T. Young. 1992. Identification and characterization of three genes that affect expression of ADH2 in Saccharomyces cerevisiae. Genetics 132:351-9. [PubMed]

Camier, S., N. Kacherovsky, and E. T. Young. 1992. A mutation outside the two zinc fingers of ADR1 can suppress defects in either finger. Mol. Cell. Biol. 12:5758-67. [PubMed]

Thukral, S. K., M. L. Morrison, and E. T. Young. 1991. Alanine scanning site-directed mutagenesis of the zinc fingers of transcription factor ADR1: residues that contact DNA and that transactivate. Proc. Natl. Acad. Sci. U.S.A. 88:9188-92. [PubMed]

Thukral, S. K., A. Eisen, and E. T. Young. 1991. Two monomers of yeast transcription factor ADR1 bind a palindromic sequence symmetrically to activate ADH2 expression. Mol. Cell. Biol. 11:1566-77. [PubMed]

Taylor, W. E., and E. T. Young. 1990. cAMP-dependent phosphorylation and inactivation of yeast transcription factor ADR1 does not affect DNA binding. Proc. Natl. Acad. Sci. U.S.A. 87:4098-102. [PubMed]

Price, V. L., W. E. Taylor, W. Clevenger, M. Worthington, and E. T. Young. 1990. Expression of heterologous proteins in Saccharomyces cerevisiae using the ADH2 promoter. Methods Enzymol. 185:308-18. [PubMed]

Parraga, G., S. Horvath, L. Hood, E. T. Young, and R. E. Klevit. 1990. Spectroscopic studies of wild-type and mutant "zinc finger" peptides: determinants of domain folding and structure. Proc. Natl. Acad. Sci. U.S.A. 87:137-41. [PubMed]

Mooney, D. T., D. B. Pilgrim, and E. T. Young. 1990. Mutant alcohol dehydrogenase (ADH III) presequences that affect both in vitro mitochondrial import and in vitro processing by the matrix protease. Mol. Cell. Biol. 10:2801-8. [PubMed]

1989 - 1980

Yu, J., M. S. Donoviel, and E. T. Young. 1989. Adjacent upstream activation sequence elements synergistically regulate transcription of ADH2 in Saccharomyces cerevisiae. Mol. Cell. Biol. 9:34-42. [PubMed]

Thukral, S. K., M. A. Tavianini, H. Blumberg, and E. T. Young. 1989. Localization of a minimal binding domain and activation regions in yeast regulatory protein ADR1. Mol. Cell. Biol. 9:2360-9. [PubMed]

Allison, D. S., and E. T. Young. 1989. Mutations in the signal sequence of prepro-alpha-factor inhibit both translocation into the endoplasmic reticulum and processing by signal peptidase in yeast cells. Mol. Cell. Biol. 9:4977-85. [PubMed]

Parraga, G., S. J. Horvath, A. Eisen, W. E. Taylor, L. Hood, E. T. Young, and R. E. Klevit. 1988. Zinc-dependent structure of a single-finger domain of yeast ADR1. Science 241:1489-92. [PubMed]

O'Hara, P. J., H. Horowitz, G. Eichinger, and E. T. Young. 1988. The yeast ADR6 gene encodes homopolymeric amino acid sequences and a potential metal-binding domain. Nucleic Acids Res. 16:10153-69. [PubMed]

Eisen, A., W. E. Taylor, H. Blumberg, and E. T. Young. 1988. The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2. Mol. Cell. Biol. 8:4552-6. [PubMed]

Blumberg, H., T. A. Hartshorne, and E. T. Young. 1988. Regulation of expression and activity of the yeast transcription factor ADR1. Mol. Cell. Biol. 8:1868-76. [PubMed]

Allison, D. S., and E. T. Young. 1988. Single-amino-acid substitutions within the signal sequence of yeast prepro-alpha-factor affect membrane translocation. Mol. Cell. Biol. 8:1915-22. [PubMed]

Taguchi, A. K., and E. T. Young. 1987. The cloning and mapping of ADR6, a gene required for sporulation and for expression of the alcohol dehydrogenase II isozyme from Saccharomyces cerevisiae. Genetics 116:531-40. [PubMed]

Taguchi, A. K., and E. T. Young. 1987. The identification and characterization of ADR6, a gene required for sporulation and for expression of the alcohol dehydrogenase II isozyme from Saccharomyces cerevisiae. Genetics 116:523-30. [PubMed]

Pilgrim, D., and E. T. Young. 1987. Primary structure requirements for correct sorting of the yeast mitochondrial protein ADH III to the yeast mitochondrial matrix space. Mol. Cell. Biol. 7:294-304. [PubMed]

Irani, M., W. E. Taylor, and E. T. Young. 1987. Transcription of the ADH2 gene in Saccharomyces cerevisiae is limited by positive factors that bind competitively to its intact promoter region on multicopy plasmids. Mol. Cell. Biol. 7:1233-41. [PubMed]

Blumberg, H., A. Eisen, A. Sledziewski, D. Bader, and E. T. Young. 1987. Two zinc fingers of a yeast regulatory protein shown by genetic evidence to be essential for its function. Nature 328:443-5. [PubMed]

Shuster, J., Yu, J., Cox, D., Chan, R.V., Smith, M. and Young, E.T. 1986. ADR1-mediated regulation of ADH2 requires an inverted repeat sequence. Mol. Cell. Biol. 6:1894-1902. [PubMed]

van Loon, A. P., and E. T. Young. 1986. Intracellular sorting of alcohol dehydrogenase isoenzymes in yeast: a cytosolic location reflects absence of an amino-terminal targeting sequence for the mitochondrion. EMBO J. 5:161-5. [PubMed]

Hartshorne, T. A., H. Blumberg, and E. T. Young. 1986. Sequence homology of the yeast regulatory protein ADR1 with Xenopus transcription factor TFIIIA. Nature 320:283-7. [PubMed]

Young, E. T., and D. Pilgrim. 1985. Isolation and DNA sequence of ADH3, a nuclear gene encoding the mitochondrial isozyme of alcohol dehydrogenase in Saccharomyces cerevisiae. Mol. Cell. Biol. 5:3024-34. [PubMed]

Beier, D. R., A. Sledziewski, and E. T. Young. 1985. Deletion analysis identifies a region, upstream of the ADH2 gene of Saccharomyces cerevisiae, which is required for ADR1-mediated derepression. Mol. Cell. Biol. 5:1743-9. [PubMed]

Taguchi, A. K., M. Ciriacy, and E. T. Young. 1984. Carbon source dependence of transposable element-associated gene activation in Saccharomyces cerevisiae. Mol. Cell. Biol. 4:61-8. [PubMed]

Williamson, V. M., D. Cox, E. T. Young, D. W. Russell, and M. Smith. 1983. Characterization of transposable element-associated mutations that alter yeast alcohol dehydrogenase II expression. Mol. Cell. Biol. 3:20-31. [PubMed]

Russell, D. W., M. Smith, V. M. Williamson, and E. T. Young. 1983. Nucleotide sequence of the yeast alcohol dehydrogenase II gene. J. Biol. Chem. 258:2674-82. [PubMed]

Russell, D. W., M. Smith, D. Cox, V. M. Williamson, and E. T. Young. 1983. DNA sequences of two yeast promoter-up mutants. Nature 304:652-4. [PubMed]

Denis, C. L., and E. T. Young. 1983. Isolation and characterization of the positive regulatory gene ADR1 from Saccharomyces cerevisiae. Mol. Cell. Biol. 3:360-70. [PubMed]

Denis, C. L., J. Ferguson, and E. T. Young. 1983. mRNA levels for the fermentative alcohol dehydrogenase of Saccharomyces cerevisiae decrease upon growth on a nonfermentable carbon source. J. Biol. Chem. 258:1165-71. [PubMed]

Sledziewski, A., and E. T. Young. 1982. Chromatin conformational changes accompany transcriptional activation of a glucose-repressed gene in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 79:253-6. [PubMed]

Beier, D. R., and E. T. Young. 1982. Characterization of a regulatory region upstream of the ADR2 locus of S. cerevisiae. Nature 300:724-8. [PubMed]

Williamson, V. M., E. T. Young, and M. Ciriacy. 1981. Transposable elements associated with constitutive expression of yeast alcohol dehydrogenase II. Cell 23:605-14. [PubMed]

Denis, C. L., M. Ciriacy, and E. T. Young. 1981. A positive regulatory gene is required for accumulation of the functional messenger RNA for the glucose-repressible alcohol dehydrogenase from Saccharomyces cerevisiae. J. Mol. Biol. 148:355-68. [PubMed]

Williamson, V. M., J. Bennetzen, E. T. Young, K. Nasmyth, and B. D. Hall. 1980. Isolation of the structural gene for alcohol dehydrogenase by genetic complementation in yeast. Nature 283:214-6. [PubMed]

1979 - 1975

Gallis, B. M., J. P. McDonnell, J. E. Hopper, and E. T. Young. 1975. Translation of poly(riboadenylic acid)-enriched messenger RNAs from the yeast, Saccharomyces cerevisiae, in heterologous cell-free systems. Biochemistry 14:1038-46. [PubMed]

Gallis, B. M., and E. T. Young. 1975. Endogenous messenger ribonucleic acid-directed polypeptide chain elongation in a cell-free system from the yeast Saccharomyces cerevisiae. J. Bacteriol. 122:719-26. [PubMed]