Publications

Recent publications

X. Tan, LIA Calderon-Villalobos, M. Sharon, C. Zheng, CV Robinson, M. Estelle, and N. Zheng 2007. Mechanism of Auxin Perception by the TIR1 Ubiquitin Ligase. Nature 446:641-645 (Cover Story).

S. Angers, T. Li, X. Yi, MJ. MacCoss, RT Moon, and N. Zheng 2006. Molecular Architecture and Assmebly of the DDB1-Cul4A Ubiquitin Ligase Machinery. Nature 443:590-593 (doi:10.1038/nature05175).

T. Li, X. Chen, K.C. Garbutt, P. Zhou, and N. Zheng 2006. structure of DDB1 in complex with a Paramyxovirus V protein: Viral Hijack of A propeller cluster in ubiquitin ligase. Cell 124:105-117.

S. Angers, CJ Thorpe, TL Biechele, SJ Goldenberg, N. Zheng. MJ Maccoss, and RT Moon 2006.  The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol 8:348-357.

X. Chen, J. Zhang, J. Lee, PS Lin, JM Ford, N. Zheng. and P Zhou 2006.  A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins.  Mol Cell 22:489-499.

Martinez SE, Bruder S, Schultz A, N. Zheng. Schultz JE, Beavo JA, Linder JU. 2005. Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization. PNAS 102:3082-3087.

Bruder S, Linder JU, Martinez SE,, N. Zheng. Beavo JA, Schultz JE. 2005. The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. PNAS 102:3088-3092.

T. Li, N. Pavletich, B. S. Schulman, and N. Zheng 2005. High-Level Expression and Purification of Recombinant SCF ubiquitin Ligases. Ed. Raymond J. Deshaies. Methods in Enzymology Vol. 398: 125-142.

S. J. Goldenberg, T. C. Cascio, S. D. Shumway, K. C. Garbutt, J. Liu, Y. Xiong, and N. Zheng 2004. Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases. Cell 119: 517-528.

J. Zhang, N. Zheng. P. Zhou 2003. Exploring the functional complexity of cellular proteins by protein knockout. PNAS 100:14127-14132.

N. Zheng 2003. A Closer Look at the HECTic Ubiquitin Ligases.(Preview) Structure 11: 5-6.

Earlier publications

S.M. Rubin, A.L. Gall, N. Zheng, and Nikola Pavletich 2005. Structure of the Rb C-terminal Domain Bound to an E2F1-DP1 Heterodimer: A Mechanism for Phosphorylation-Induced E2F Release. Cell 123:1093-1106.

B. Hao, N. Zheng, B. A. Schulman, G. Wu, M. Pagano, and N.P. Pavletich 2005. Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubiquitin ligase.  Mol Cell 20:9-19.

Yang H, Jeffrey PD, Miller JJ, Kinnucan E, Sun Y, Thoma N. Zheng N, Chen P, Lee WH, Pavletich  NP. 2002. BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure. Science 297: 1837-1848 (Cover Story).

Zheng N & Pavletich NP 2004.  Structural Biology of the Cullin-Based Ubiquitin Ligases. Ed. John Meyer. Protein Degradation. Vol 1. Ubiquitin and the Chemistry of Life. Wiley VCH

Zheng N, Schulman B, Miller JJ, Wang P, Jeffrey PD, Chu C, Koepp DM, Elledge SD, Pagano N, Conaway RC, Conaway JW, Harper JW and Pavletich NP. 2002. Structure of the Cul1-Rbx1-Skp1-FboxSkp2 Ubiquitin-Protein Ligase Complex. Nature 416: 703-709 (Cover story).

Zheng N, Wang P, Jeffrey PD and Pavletich NP. 2000. Structure of a c-Cbl-UbcH7 Complex: RING Domain Function in Ubiquitin-Protein Ligases.  Cell 102: 533-539.

Zheng N, Fraenkel E, Pabo CO and Pavletich NP. 1999. Structural Basis of DNA Recognition by the Heterdimeric Cell Cycle Transcription Factor E2F-DP.  Genes & Dev 13 (6): 666-674 (Cover story).

Zheng N & Gierasch LM. 1997. Domain Interactions in E. coli SRP: Stabilization of the M Domain by RNA Binding Is Required for Effective Signal Sequence Modulation of the NG Domain.  Mol Cell 1: 79-87.

Cleverley RM, Zheng N, and Gierasch LM. 2001. The Cost of Exposing a Hydrophobic Loop and Implication for the Functional Role of 4.5S RNA in the E. coli SRP.  J Biol Chem (276):19327-19331.

Zheng N & Gierasch LM. 1996.  Signal Sequences: the Same yet Different. (Minireview) Cell 86: 849-852.