Biomedical Research Integrity (BRI)

The U.S. Public Health Service (PHS) requires that all pre- and post-doctoral researchers supported by PHS training grants receive training in the responsible conduct of research. The University of Washington School of Medicine Department of Bioethics and Humanities and Fred Hutchinson Cancer Research Center developed this program to enable its researchers to meet the PHS requirement. To view program information from previous years, visit: BRI Archive. We offer nine hours of training - six lectures and three discussion groups - annually. Most trainees complete their training in a single summer, however, you may attend over a multi-year period. You and your principal investigator determine your training needs, see the Update on the Requirement for Instruction in the Responsible Conduct of Research (2022) for NIH requirements by award type. The 2023 program will be hosted online via Zoom. Everyone is welcome to attend, this program is free of charge and open to the public. You do not need to have NIH funding in order to participate. 

 
       
JUN 15
JUL-SEP
JUL-AUG 
AUG 31
OCT 31
NOV 15
NOV 16-MAY 31
 
 
Registration opens 
Lectures occur
Discussions occur
Registration closes
Final day to take quizzes for lecture attendance credit
Fred Hutch Hutch Learning and UW MyResearch updated
BRI is closed
       
       
   

Conflict of Interest 

July 12, 2023, 10-11 am, Zoom
Marcia N. Gonzales, J.D.
Vice President and Chief Compliance Officer, Fred Hutch Cancer Center
       
   

Research Misconduct

July 26, 2023, 11 am-12 pm, Zoom
Elisabeth Bik, PhD
Microbiome and Science Integrity Consultant;
Founder, Microbiome Digest; 
Founder, Science Integrity Digest; 
Twitter: @microbiomdigest
       
   

Mentor/Trainee Relationships

August 8, 2023, 11 am-12 pm, Zoom
Sharona Gordon, PhD
Professor, Department of Physiology and Biophysics, University of Washington;
Founder, Below the Waterline
Twitter: @ProfSharona
       

   

Peer Review

August 22, 2023, 11 am-12 pm, Zoom
Christine Laine, MD, MPH, FACP
Editor-in-Chief, Annals of Internal Medicine
Senior Vice President, American College of Physicians
       
   

Responsible Authorship

August 29, 2023, 11 am-12 pm, Zoom
Wendy Barrington, PhD, MPH
Associate Professor, Epidemiology
Associate Professor, Child, Family, and Population Health Nursing
Associate Professor, Health Systems and Population Health
       
   

Data Management

September 12, 2023, 11 am-12 pm, Zoom
Amy Paguirigan, PhD
Senior Staff Scientist, Fred Hutch Data Science Lab
Staff Scientist, Radich Lab, Fred Hutchinson Cancer Research Center
       
       

In summer 2023, Fred Hutch and UW will host 100 discussion groups on three topics: conflict of interest; research misconduct, and mentor/trainee relationships. All participants were welcome to attend UW discussions; Fred Hutch groups were for Fred Hutch trainees only. 

Discussion Group Schedule and Discussion Guides (2020-2023)  
 
 

Information for Grant Applications

How BRI 2022 Fulfilled RCR Requirements (including dates, topics, facilitator, and speaker info)

 

Summary

  1. Format - the required format of instruction, i.e., face-to-face lectures, coursework, and/or real-time discussion groups.
    BRI: lectures and discussions occurred in real-time, with live Q&A, on Zoom. Assigned readings were provided in advance.
  2. Subject Matter - the breadth of subject matter, e.g., conflict of interest, authorship, data management, human subjects and animal use, laboratory safety, research misconduct, research ethics;
    BRI: the five main themes were research misconduct, responsible authorship, data management, peer review, and conflict of interest. Additional subject matter was covered (see below) with the exception of human subjects and animal use.
  3. Faculty Participation - the role of the program faculty in the instruction;
    BRI: five faculty members gave one lecture each; 66 faculty members facilitated one or more discussion groups for a total of five lectures and 90 discussion groups.
  4. Duration of Instruction - the number of contact hours of instruction, taking into consideration the duration of the program; and
    BRI: 95 contact hours were offered, including five lectures and 90 discussion groups; trainees took an average of eight hours each. The duration of the program was July 1-September 5, 2022.
  5. Frequency of Instruction - instruction must occur during each career stage and at least once every four years.
    BRI: we offer training every summer, trainees may participate in BRI as often as they like.
       
Email uwbri@uw.edu  |  Watch YouTube  |  Subscribe bri-series@uw.edu  |  Follow @uwbri Twitter and Facebook

More Information

Background

Sponsored by the University of Washington School of Medicine and Department of Bioethics & Humanities

The Public Health Service (PHS) and its research institutions require that all pre-and post-doctoral researchers supported by PHS training grants receive training in the responsible conduct of research. The School of Medicine has developed a program of lectures with associated discussion groups, entitled the Biomedical Research Integrity (BRI) Program, for its researchers to meet this requirement. All School of Medicine trainees are required to participate.

Goals 

Upon program completion, BRI participants will be able to:

1.   Recognize ethical issues and challenges to integrity that arise in the course of routine research practice;
2.   Formulate a justified response to research challenges, using select ethical decision-making tools; and
3.   Identify a sense of professional responsibility to take action and make good judgments that work to support good research practices.

 

Mission Statement

 

Update on the Requirement for Instruction in the Responsible Conduct of Research  

Note: This RCR training meets the NIH educational requirement for research trainees. This is NOT the RCR training site for NSF-funded undergrad/post-doc students. For more information on the NSF training, please visit their website NSF-FUNDED RCR training information.   

 

NIH Annual Review of Ethics (Case Studies)

We offer eight hours of training - five lectures and three discussion groups - every summer. Most trainees complete all eight hours in a single summer, however, you may attend over a multi-year period. You and your principal investigator determine your training needs, see the Update on the Requirement for Instruction in the Responsible Conduct of Research for NIH requirements by award type. The 2021 program will be hosted online via Zoom. Everyone is welcome to attend - even researchers outside of UW - this program is free of charge. You do not need to have NIH funding in order to participate.

 

The BRI program meets the PHS requirement for instruction in the Responsible Conduct of Research in National Research Service Award Institutional Training Grants (NIH Guide, 1994). The program covers the following topics (representing five of the seven required topics) described in the NIH Guide:

Note: Each BRI lecturer will also be asked to incorporate explicit reference to researcher/trainee responsibilities and/or collaborative science.  These two topics are not currently required by NIH; however, they were included in a list of required topics prepared by NIH in 2000 (subsequently suspended) and inclusion of these topics is the national norm for RCR training.  Discussion of many of the required topics is incomplete without reference to these issues.

  1. The two additional required RCR topics are: policies regarding the use of human and animal subjects; these are required only when directly applicable to the trainee’s work.  These topics are covered through existing UW training programs.
  2. We offer three rounds of BRI case discussion groups each summer.  Each case discussion group will include cases covering two required RCR topics and one non-required topics – e.g., cases in a given session might address conflict of interest, peer review and collaborative science.  Discussion groups also address the scientist as a responsible member of society, contemporary ethical issues in biomedical research, and the environmental and societal impacts of scientific research. This approach provides trainees with useful redundancy in case review and acknowledges the many overlaps in RCR topics.

For those seeking more resources and guidance on a topic, please see the BRI resources website for links to local and national policies, sample cases with discussion, and current articles.

Please check with the Principal Investigator of the grant on which you are supported to determine the number of lectures and discussion groups required to satisfy the NIH requirement.

 

FY 2022 Updated Guidance: Requirement for Instruction in the Responsible Conduct of Research [Notice Number: NOT-OD-22-055, 2/17/2022]

Office of Research Integrity (ORI) at DHHS

This site contains information on handling misconduct, on policies and regulations, RCR education, and more.  There are resources and links for data management, animal and human subjects research, conflicts of interest, peer review, collaboration, publication/authorship, mentorship, research misconduct, and more.

The Office of Research Integrity (ORI) oversees and directs Public Health Service (PHS) research integrity activities on behalf of the Secretary of Health and Human Services with the exception of the regulatory research integrity activities of the Food and Drug Administration.

Organizationally, ORI is located within the Office of Public Health and Science (OPHS) within Office of the Secretary of Health and Human Services (OS) in the Department of Health and Human Services (HHS).

The PHS is composed of the following offices and agencies:

Office of Public Health and Science
National Institutes of Health.
The Centers for Disease Control and Prevention
The Food and Drug Administration
The Substance Abuse and Mental Health Services Administration
The Health Resources and Services Administration
The Agency for Healthcare Research and Quality.
The Agency for Toxic Substances and Disease Registry
The Indian Health Service
Office of Regional Health Administrators

OHRP - Human Subjects Research Videos

Announcement: Educational Videos Now Available, US Office for Human Research Protections (OHRP), Jul 14, 2010
"OHRP is pleased to announce the availability for the first time of educational videos on the HHS YouTube channel. The videos include "Research Use of Human Biological Specimens and Other Private Information" and "Reviewing and Reporting Unanticipated Problems and Adverse Events," in addition to two new videos "Institutional Review Board (IRB) Membership" and "General Informed Consent Requirements Parts I Research Investigator and Part II Research Subject"…"

 

Resources

ATTENDANCE IS TIED TO YOUR EMAIL ADDRESS, PLEASE TYPE IT CORRECTLY AND USE IT CONSISTENTLY! 

 

How to View Attendance Records

 

Lectures. You may participate in two ways: 
 

  1. Attend the live lecture via Zoom
    Attendance is tied to your Zoom registration email, please type it correctly! Per NIH policy, you must attend at least 50 minutes to receive credit for one contact hour. You will receive attendance confirmation via email within 24 hours of the live lecture; training records in UW MyResearch Portal and Hutch Learning will be updated by November 15. 
     
  2. Watch the video recording and take the relevant quiz by October 31
    Recordings will be posted within 24 hours of the live lecture; quizzes will be posted within one week. For attendance credit, take the relevant quiz by October 31. You will receive attendance confirmation by the end of the month in which you take the quiz; training records in UW MyResearch Portal and Hutch Learning will be updated by November 15.
     

Discussion Groups. Attend live via Zoom 

 

  • Attend discussions live via Zoom. Attendance is tied to your Zoom registration email, please type it correctly! Per NIH policy, you must attend at least 50 minutes to receive credit for one contact hour. You will receive attendance confirmation via email within 24 hours of the discussion; training records in UW MyResearch Portal and Hutch Learning will be updated by November 15, 2020. To reschedule your UW discussion group, visit the URL sent in your confirmation email, select a new date/time, and select "Submit. To cancel your UW discussion group, visit the URL sent in your confirmation email, select "Reset", and select "Submit".
     
  • When you register with BRI, you are taking a spot that is needed by other trainees. If you cannot attend, please reschedule at least 72 in advance of the discussion group. 
     

For lecture attendance credit, you must watch the live Zoom lecture or take the lecture quiz by October 31. For discussion group attendance credit, you must must participate in one of the 80+ live discussion groups we offer in July and August. Attendance issues will be addressed between June 1 and November 15. The BRI program is closed between November 15 and May 1. 

Attendance is recorded and subject to PHS review. Please refer to the BRI Mission Statement and the NIH Update on the Requirement for Instruction in the Responsible Conduct of Research

 

We offer eight hours of training - five lectures and three discussion groups - every summer. Most trainees complete all eight hours in a single summer, however, you may attend over a multi-year period. You and your principal investigator determine your training needs, see the Update on the Requirement for Instruction in the Responsible Conduct of Research for NIH requirements by award type. The 2021 program will be hosted online via Zoom. Everyone is welcome to attend - even researchers outside of UW - this program is free of charge. You do not need to have NIH funding in order to participate.

2023 Board

 

Melissa Cox, MLIS, Education Specialist, Department of Bioethics and Humanities, UW

Malia Fullerton, PhD, Director, Biomedical Research Integrity Program, UW

Amber Ismael, PhD, Office of Scientific Career Development Manager, Research Administration and Faculty Affairs, Fred Hutch

Karen Peterson, PhD, Director, Research Ethics Education, Research Administration and Faculty Affairs, Fred Hutch

 

2022 Board

 

Rachel Bender Ignacio, MD, MPH, Associate Vaccine and Infectious Disease Division, Fred Hutch

Melissa Cox, MLIS, Education Specialist, Department of Bioethics and Humanities, UW

David Dichek, MD, Professor of Medicine, UW

Malia Fullerton, PhD, Director, Biomedical Research Integrity Program, UW

Amber Ismael, PhD, Office of Scientific Career Development Manager, Research Administration and Faculty Affairs, Fred Hutch

Karen Peterson, PhD, Director, Research Ethics Education, Research Administration and Faculty Affairs, Fred Hutch

David Raible, PhD, Professor, Department of Biological Structure, UW

Discussions

Each summer, BRI hosts approximately 100 discussion sessions on three topics. See the schedules, including facilitator information, here: Discussion Group Schedules, 2020-2021 

 

Lectures

Data Acquisition, Management, Sharing, and Ownership

Monday, July 6, 2020, 4-5 pm

Anna Lauren Hoffman, PhD, MLIS, Assistant Professor, UW Information School

Title: Just Because It’s Fair Doesn’t Mean It’s Right: Confronting the Possibilities and Limits of Our Ethical Commitments 

 

Research Misconduct

Monday, July 20, 2020, 4-5 pm

Barry Stoddard, PhD, Director, NCI Interdisciplinary Training Program in Cancer, Fred Hutchinson Cancer Research Center; Professor, Fred Hutchinson Cancer Research Center

Senior Editor, Nucleic Acids Research; 

Title: Adventures in Editing: Eye-Opening Behavior and Misbehavior in the World of Scientific Publishing

 

Responsible Authorship and Publication

Monday, August 3, 2020, 4-5 pm

Ferric C. Fang, MD, Professor, Department of Laboratory Medicine, UW School of Medicine; Director, Clinical Microbiology Laboratory, Harborview Medical Center; NIH Topic: Responsible Authorship and Publication

Title: Responsible Authorship and Publication

 

Conflict of Interest

Thursday, August 20, 2020, 4-5 pm

Sharona Gordon, PhD, Professor, Physiology & Biophysics, UW Biological Physics, Structure, & Design; Associate Dean for Research and Graduate Education, UW School of Medicine; NIH 

Title: Conflict of Interest, Competition, and Cooperation in Science

 

Peer Review

Monday, August 31, 2020, 4-5 pm 

C.K. Gunsalus, JD, Director, National Center for Professional and Research Ethics; Professor Emerita of Business and Research Professor, Coordinated Sciences Laboratory, University of Illinois at Urbana-Champaign 

Title: Peer Review

Discussions

Each summer, BRI hosts approximately 100 discussion sessions on three topics. See the schedules, including facilitator information, here: Discussion Group Schedules, 2020-2021 

Lectures

       
   

Peer Review | Monday, August 31, 2020, 4-5 pm 

Title: "Peer Review"
Speaker: C.K. Gunsalus, JD
Director, National Center for Professional and Research Ethics; Professor Emerita of Business and Research Professor, Coordinated Sciences Laboratory, University of Illinois at Urbana-Champaign 
Host: Malia Fullerton, DPhil, Director, Biomedical Research Integrity Program 
       
   

Responsible Authorship and Publication | Wednesday, July 7, 2021, 12-1 pm PST

Title: "Crisis in Biomedical Science: Time for Reform"
Speaker: Arturo Casadevall, MD, PhD
Chair, Molecular Microbiology & Immunology; Alfred & Jill Sommer Professor and Chair; and Bloomberg Distinguished Professor; at Johns Hopkins Bloomberg School of Public Health
Host: Malia Fullerton, DPhil, Director, Biomedical Research Integrity Program 
Lecture Two Video 
       
   

Research Misconduct | Tuesday, July 20, 2021, 4-5 pm PST

Title: "The Seattle Flu Study: Implications of Public Health Research During a Pandemic"
Speaker: Helen Y. Chu, MD, MPH
Associate Professor, Department of Medicine, Allergy & Infectious Diseases; Adjunct Associate Professor, Department of Epidemiology; Adjunct Associate Professor, Department of Global Health; and Attending Physician, Infectious Diseases; University of Washington Department of Medicine; Physician-Scientist, Harborview Medical Center
Host: Malia Fullerton, DPhil, Director, Biomedical Research Integrity Program 
Lecture Three Video 
       
   

Conflict of Interest | Tuesday, July 27, 2021, 4-5 pm PST

Title: "Avoiding Conflict of Interest Morbidity and Mortality"
Speaker: Stephanie Lee, MD, MPH
Professor and Associate Director, Clinical Research Division, and David and Patricia Giuliani/Oliver Press Endowed Chair in Cancer Research, Fred Hutchinson Cancer Research Center
Host: Karen Peterson, PhD, Director, Research Ethics Education, Fred Hutchinson Cancer Research Center
Lecture Four Video 
       
   

Data Acquisition, Management, Sharing, and Ownership | Wednesday, August 4, 2021, 12-1 pm PST

Title: "So Much Data and So Many Ways to Mess Up"
Speaker: James Mickens, PhD
Gordon McKay Professor of Computer Science, Harvard School of Engineering & Applied Sciences; Director, Berkman Klein Center for Internet & Society; and Faculty Team Leader, Embedded EthiCS; at Harvard University
Host: Malia Fullerton, DPhil, Director, Biomedical Research Integrity Program 
Lecture Five Video 

Discussion Group Schedule and Discussion Guides (2020-2022)  

       
   

Research Misconduct 
Painted Mice to Flipped Blots: 
the Past, Present, and Future of Research Misconduct
Wednesday, July 13, 4-5 pm, Zoom, (Register)
Julie Severson, PhD, JD
Director, Office of Research Misconduct Proceedings
University of Washington
Recording 
       
   

Responsible Authorship and Publication
Communication Breakdown:
Navigating the Tumultuous Seas of Authorship and Mentorship
Wednesday, July 20, 4-5 pm, Zoom (Register) 
Atom Lesiak, PhD
Director, Genome Sciences Education Outreach
University of Washington
Recording 
       
Cho    

Data Acquisition, Management, Sharing, and Ownership 
Data Ethics, Responsibility and Values
Thursday, July 28, 4-5 pm, Zoom (Register) 
Mildred Cho, PhD
Professor, Departments of Medicine and Pediatrics
Associate Director, Stanford Center for Biomedical Ethics
Stanford University
Recording 
       

 

    

Peer Review 
Good, Bad and Ugly Authorship and Peer Review Practices
Taken from a Journal Editor’s Desk
Wednesday, August 24, 4-5 pm, Zoom (Register)
Barry Stoddard, PhD
Senior Editor, Nucleic Acids Research 
Director, NCI Interdisciplinary Training Program in Cancer
Professor, Basic Sciences Division
Fred Hutchinson Cancer Research Center
Recording 
       
   

Conflict of Interest
Title: Conflict of Interest
Tuesday, August 30, 2-3 pm, Zoom (Register)
Lisa Bero, Ph.D.
Professor of Medicine and Public Health
Chief Scientist, Center for Bioethics and Humanities
University of Colorado Anschutz Medical Campus
Recording 

Schedule of One-Hour Discussion to Share with Participants, Including Cases

Post in Zoom Chat: 

Facilitator Training Presentation

Facilitator Training Recording 

Facilitator Forum -- a place to share ideas and ask questions

Discussion Guides: 

Post-Lecture Debriefs for Facilitators

Local Resources

National Resources

Programming and Content:

Malia Fullerton, Director, Biomedical Research Integrity Program, UW, smfllrtn@uw.edu

Karen Peterson, Director, Research Ethics Education, Research Administration and Faculty Affairs, Fred Hutch, kpeterso@fhcrc.org

 

Administration and Attendance:

Melissa Cox, Education Specialist, Department of Bioethics and Humanities, UW, mdcox@uw.edu 

Amber Ismael, Office of Scientific Career Development Manager, Research Administration and Faculty Affairs, Fred Hutch, aismael@fredhutch.org

 

Oversight: 

Lynette Arias, Assistant Vice Provost for Research Administration Strategic Initiatives, Office of Research, University of Washington, ariasl@uw.edu

Mari Ostendorf, Vice Provost for Research, Office of Research, University of Washington, ostendor@uw.edu

Melissa Peterson, Assistant Vice Provost for Research Compliance, Office of Research, University of Washington, petermm@uw.edu

Julie Severson, Director, Office of Research Misconduct Proceedings, Office of Research, University of Washington, severson@uw.edu