Glycosylation is a dominant feature of extracellular phenotypes. Glycoproteins present distinct combinations of glycans and amino acids that create unique molecular surfaces to relay biological information in a language called the glycocode. Despite evidence that the glycocode orchestrates numerous aspects of cell surface biology, we lack a fundamental understanding of the glycosylation landscape across the proteome, largely because we do not have tools to capture the glycocode at a systems level. Through innovations in mass spectrometry and chemical biology, our group works to address this critical gap in current analytical technology to study glycocode regulation across biological networks that govern health and disease.
