Research

We study homeostatic control and its deterioration. As described by W. Cannon, homeostasis is defined as a self-regulated mechanism by which biological systems maintain stability while adjusting to changing conditions. Adjustment is achieved by the activation of autonomic reflexes. Hence, we study the autonomic nervous system, and our motivation is to understand the fundamental molecular and cellular mechanisms of visceral motor control by this system. We aspire to employ a multilevel approach, having a research program that sits at the intersection of molecular biophysics (ion channels and signaling microdomains), cellular physiology (single-cell activity), and systems physiology (tissue architecture and function).

We are currently pursuing two lines of research. One of our research lines builds on my discoveries and focuses on identifying the molecular mechanisms behind ion channel signaling from microdomains. We use big potassium (BK) and voltage-gated calcium (CaV) channels as a model of microdomain signaling. Spatial localization of BK channels near calcium sources is critical for their function. The second line of research seeks to determine the cellular and molecular mechanisms underlying multiple age-driven disorders associated with autonomic dysfunction.

Join our laboratory and help us explore the molecules that regulate neuronal excitability and cellular physiology. We are passionate about autonomic neuroscience, cardiovascular neural control, and aging research. Uncovering novel mechanisms continuously thrills us, and we extend a warm invitation to motivated students to apply.