Betsy Rolland, HCDE PhD student and CSC Lab member is researching coordination and support of collaborative biomedical research. She is also the Project Manager for the Asia Cohort Consortium Coordinating Center at the Fred Hutchinson Cancer Research Center in Seattle, WA. The Asia Cohort Consortium (ACC) is a biomedical research collaboration comprised of more than 20 Asia-based cohort studies seeking to build a collective cohort of over a million people. The New England Journal of Medicine article below is a product of the collaboration of the ACC.
Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians
Wei Zheng, M.D., Ph.D., Dale F. McLerran, M.S., Betsy Rolland, M.L.I.S., Xianglan Zhang, M.D., M.P.H., Manami Inoue, M.D., Ph.D., Keitaro Matsuo, M.D., Ph.D., Jiang He, M.D., Ph.D., Prakash Chandra Gupta, Sc.D., Kunnambath Ramadas, M.D., Shoichiro Tsugane, M.D., Ph.D., Fujiko Irie, M.D., Ph.D., Akiko Tamakoshi, M.D., Ph.D., Yu-Tang Gao, M.D., Renwei Wang, M.D., Xiao-Ou Shu, M.D., Ph.D., Ichiro Tsuji, M.D., Ph.D., Shinichi Kuriyama, M.D., Hideo Tanaka, M.D., Ph.D., Hiroshi Satoh, M.D., Ph.D., Chien-Jen Chen, Sc.D., Jian-Min Yuan, M.D., Ph.D., Keun-Young Yoo, M.D., Ph.D., Habibul Ahsan, M.D., Wen-Harn Pan, Ph.D., Dongfeng Gu, M.D., Ph.D., Mangesh Suryakant Pednekar, Ph.D., Catherine Sauvaget, M.D., Ph.D., Shizuka Sasazuki, M.D., Ph.D., Toshimi Sairenchi, Ph.D., Gong Yang, M.D., M.P.H., Yong-Bing Xiang, M.D., M.Ph., Masato Nagai, M.Sc., Takeshi Suzuki, M.D., Ph.D., Yoshikazu Nishino, M.D., Ph.D., San-Lin You, Ph.D., Woon-Puay Koh, M.B., B.S., Ph.D., Sue K. Park, M.D., Ph.D., Yu Chen, Ph.D., Chen-Yang Shen, Ph.D., Mark Thornquist, Ph.D., Ziding Feng, Ph.D., Daehee Kang, M.D., Ph.D., Paolo Boffetta, M.D., M.P.H., and John D. Potter, M.D., Ph.D.
N Engl J Med 2011; 364:719-729February 24, 2011
Background
Most studies that have evaluated the association between the body-mass index (BMI) and the risks of death from any cause and from specific causes have been conducted in populations of European origin.
Methods
We performed pooled analyses to evaluate the association between BMI and the risk of death among more than 1.1 million persons recruited in 19 cohorts in Asia. The analyses included approximately 120,700 deaths that occurred during a mean follow-up period of 9.2 years. Cox regression models were used to adjust for confounding factors.
Results
In the cohorts of East Asians, including Chinese, Japanese, and Koreans, the lowest risk of death was seen among persons with a BMI (the weight in kilograms divided by the square of the height in meters) in the range of 22.6 to 27.5. The risk was elevated among persons with BMI levels either higher or lower than that range — by a factor of up to 1.5 among those with a BMI of more than 35.0 and by a factor of 2.8 among those with a BMI of 15.0 or less. A similar U-shaped association was seen between BMI and the risks of death from cancer, from cardiovascular diseases, and from other causes. In the cohorts comprising Indians and Bangladeshis, the risks of death from any cause and from causes other than cancer or cardiovascular disease were increased among persons with a BMI of 20.0 or less, as compared with those with a BMI of 22.6 to 25.0, whereas there was no excess risk of either death from any cause or cause-specific death associated with a high BMI.
Conclusions
Underweight was associated with a substantially increased risk of death in all Asian populations. The excess risk of death associated with a high BMI, however, was seen among East Asians but not among Indians and Bangladeshis.
